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Experimental training in molecular pharmacology education based on drug –target interactions
ConclusionThe designed experimental training program has a positive effect on the training of pharmacology talents, and can be implemented as a part of molecular pharmacology education. (Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - August 10, 2023 Category: Drugs & Pharmacology Authors: Luna Ge, Kai Cheng, Yuang Zhang, Junling Li, Wei Chen, Guanhua Song, Lin Wang Tags: ORIGINAL ARTICLE Source Type: research

Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta ‐analysis of randomized controlled trials
In conclusion, moderate-to-low certainty evidence supports the use of IVIB for adults with postoperative pain and fever who are unable to take oral medications. (Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - August 3, 2023 Category: Drugs & Pharmacology Authors: Pengxiang Zhou, Lu Chen, Ente Wang, Lanzhi He, Shuxia Tian, Suodi Zhai Tags: REVIEW Source Type: research

Drug interactions of tacrolimus with letermovir and azole antifungals following hematopoietic stem cell transplantation: A retrospective observational analysis
Comparison of C/D ratio of tacrolimus when co-administered with and without letermovir according to azole antifungals. Thex-andy-axes represent the categories and C/D ratios of tacrolimus, respectively. The closed circles represent the C/D ratios in patients with fluconazole. The closed squares represent the C/D ratios in patients with voriconazole. The open circles represent the C/D ratios in patients without azole antifungals. C/D ratios were compared according to co-administered letermovir by the Wilcoxon signed-rank test. ΔC/D ratios were compared by the Mann–WhitneyU test. C/D, concentration and dose-normalized by ...
Source: Pharmacology Research and Perspectives - August 2, 2023 Category: Drugs & Pharmacology Authors: Yuri Shinogi, Toshinori Hirai, Miki Ishibashi, Kazuko Ino, Isao Tawara, Takuya Iwamoto Tags: ORIGINAL ARTICLE Source Type: research

Could cannabinoids provide a new hope for ovarian cancer patients?
A summary of the altered signalling pathways and proteins leading to evasion of cell death via apoptosis, cell cycle arrest and autophagy in ovarian cancer that are affected by cannabinoids. AbstractIt is known that gynecological cancers remain a worldwide problem and as shown by the statistics, there is a need for new gynecological cancer treatments. Cannabinoids, the pharmacologically active compounds of theCannabis sativa plant, have been used for many centuries by individuals as a symptomatic treatment to alleviate pain, nausea, vomiting, and to help stimulate appetite. Research has revealed that cannabinoids also exer...
Source: Pharmacology Research and Perspectives - August 2, 2023 Category: Drugs & Pharmacology Authors: Rimanee Kaur, Farideh A. Javid Tags: REVIEW Source Type: research

How to approach a study in ethnopharmacology? Providing an example of the different research stages for newcomers to the field today
AbstractEthnopharmacology seeks to investigate humankind's use of natural materials, such as plants, fungi, microorganisms, animals, and minerals, for medicinal purposes. In this highly interdisciplinary field, which can be described as a bridge between the natural/medical and socio-cultural sciences, pharmacological, anthropological, and socio-cultural research methods are often applied, along with methods from other branches of science. When entering the field of ethnopharmacology as a newcomer, student, or early career researcher today, the tremendous amount of scientific publications, and even classical books from this...
Source: Pharmacology Research and Perspectives - July 28, 2023 Category: Drugs & Pharmacology Authors: Fabien Schultz, Leif ‐Alexander Garbe Tags: REVIEW Source Type: research

Oral morphine induces spinal 5 ‐hydroxytryptamine (5‐HT) release using an opioid receptor‐independent mechanism
Oral morphine (100 mg/kg) increased significant spinal 5-HT release.This 5-HT release was not antagonized by either beta-FNA or naloxone and this suggested that morphine induced 5-HT release was mediated by an opioid receptor-independent mechanism. AbstractMorphine induces spinal 5-hydroxytryptamine (5-HT) release, but the role and mechanism of the spinal 5-HT release induced by morphine are not well understood. The purpose of this study was to define the role and mechanism of spinal 5-HT release induced by oral morphine. We also examined whether persistent pain affected the spinal 5-HT release induced by oral morphine. Sp...
Source: Pharmacology Research and Perspectives - July 25, 2023 Category: Drugs & Pharmacology Authors: Shingo Nakamura, Shuji Komatsu, Toshihiko Yamada, Hiromi Kitahara, Tatsuo Yamamoto Tags: ORIGINAL ARTICLE Source Type: research

An analysis of patterns of distribution of buprenorphine in the United States using ARCOS, Medicaid, and Medicare databases
This study characterized changes in buprenorphine use. Using the Drug Enforcement Administration's ARCOS, Medicaid, and Medicare claims databases, patterns in buprenorphine usage in the United States from 2018 to 2020 were analyzed by examining percentage changes in total grams distributed and changes in grams per 100  K people in year-to-year usage based on ZIP code and state levels. For ARCOS from 2018 to 2019 and 2019 to 2020, total buprenorphine distribution in grams increased by 16.2% and 12.6%, respectively. South Dakota showed the largest statewide percentage increase in both 2018–2019 (66.1%) and 2019 –2020 (...
Source: Pharmacology Research and Perspectives - July 24, 2023 Category: Drugs & Pharmacology Authors: Zhi ‐Shan Hsu, Justina A. Warnick, Tice R. Harkins, Briana E. Sylvester, Neal K. Bharati, leTausjua B. Eley, Stephanie D. Nichols, Kenneth McCall, Brian J. Piper Tags: ORIGINAL ARTICLE Source Type: research

The potencies and neurotoxicity of intrathecal levobupivacaine in a rat spinal model: Effects of concentration
This study was aimed at examining the anesthetic effects and spinal cord injuries in the rats by intrathecal injection of levobupivacaine at different concentrations. Rats with successful intrathecal cannulation were selected and randomly divided into six groups (n = 72), and administered 0.1 mL of 0.125%, 0.25%, 0.5%, or 0.75% levobupivacaine, saline or 5% lidocaine via intrathecal catheters. The potency of levobupivacaine was evaluated by walking behavior. To identify the motor and sensory function, walking behavior and paw withdrawal thresholds (PWTs ) were measured once a day. After 7 days, the L4–5 spinal co...
Source: Pharmacology Research and Perspectives - July 21, 2023 Category: Drugs & Pharmacology Authors: Luyue Gao, Zhen Yang, Sisi Zeng, Jiabei Li, Na Wang, Fangjun Wang Tags: ORIGINAL ARTICLE Source Type: research