Effect of tenofovir containing ART on renal function in patients with moderate/severe reduced creatinine clearance at baseline: A retrospective study at two referral hospitals in Namibia

Panel A shows median CrCl values for patients in the four stages of CrCl at baseline. Panel B shows the follow-up median CrCl for the same baseline stages. A drop is observed for stages 1 and 2, while increases are observed for stages 3 and 4. AbstractPrescription of tenofovir disoproxil fumarate (TDF) for patients with baseline creatinine clearances (CrCl)<60  mL/min is said to increase risk of further decline in CrCl. Study objectives were to assess incidence of improvement and predictors thereof; to assess incidence of decline and transition to lower stages of CrCl; and comparison of declines between patients with a baseline CrCl <  60mL/min (group-I) and ≥ 60 mL/min (group-II). The study was retrospective, included patients 16 yrs or older who received TDF-containing ART. Improvement and decline were defined as ≥ 25% increase or decrease in CrCl, respectively. Binary logistic regression was performed to identify pr edictors of improvement. Groups I and II had 2862 and 7526 patients, respectively. In group-I, improvement in CrCl was observed in 40.1% (n = 1146), and was associated with stage IV of CrCl (adjusted Odds Ratio [aOR]=13.4 [95% CI: 6.7 - 26.9,P <  .001]); male gender (aHR = 1.8 [95% CI: 1.5 - 2.2,P <  .001]); and a poor HIV-status (aHR = 1.2 [95% CI: 1.0 - 1.4],P = .033). In group-I and group-II, respectively, decline occurred in 2.3% and 13.0%, (P <  .001); transition to lower stages occurred in 1.0% and 25.2% (P < ...
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research