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[ASAP] Leveraging Prior Knowledge to Support Early Phase Clinical Trial Applications: Regulatory CMC Considerations and Case Studies
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00040 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - April 4, 2023 Category: Chemistry Authors: Sofie Fogh Hedegaard, Rosa Rebecca Erritze Hansen, Robert Nelson, Niels Kristian Klausen, Christian Fogt Hjorth, Lori Troup, Marie Eskling, Morten Storgaard, Saad Khu ̈rshid, and Scott W. Roberts Source Type: research

[ASAP] Green Chemistry Articles of Interest to the Pharmaceutical Industry
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00065 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - April 4, 2023 Category: Chemistry Authors: Marian C. Bryan ◊, Charlotte Dalton, Alba Díaz-Rodríguez, Jaika Doerfler, Oliver D. Engl, Alejandro Gimenez Molina, Vanessa Harawa, Christopher B. Kelly◊, Wei Li, Rachel H. Munday, Jan Pawlas, Paul F. Richardson, William J. Smith, III, Alan Steven Source Type: research

[ASAP] Toward the Development of a Manufacturing Process for Milvexian: Scale-Up Synthesis of the Side Chain
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00399 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - April 3, 2023 Category: Chemistry Authors: Simon Wagschal, Diego Broggini, Trung D.C. Cao, Pascal Schleiss, Kristian Paun, Jessica Steiner, Anna-Lena Merk, Joachim Harsdorf, Winfried Fiedler, Stefan Schirling, Sven Hock, Tobias Strittmatter, Jan Dijkmans, Ivan Vervest, Tim Van Hoegaerden, Brecht E Source Type: research

[ASAP] A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00291 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - March 31, 2023 Category: Chemistry Authors: Paridhi Agrawal, Katerina Wilkstein, Emily Guinn, McKensie Mason, Carolina I. Serrano Martinez, and Jeremiah Saylae Source Type: research

[ASAP] A Novel and Practical Synthesis of 5 ‑Fluoro-1-(2-fluorobenzyl)‑1 < italic toggle="yes" > H < /italic > ‑pyrazolo[3,4‑ < italic toggle="yes" > b < /italic > ]pyridine-3-carbonitrile, a Key Intermediate of Vericiguat
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00011 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - March 30, 2023 Category: Chemistry Authors: Siju Bi, Wenshuang Diao, Ting Tian, Ting Zhou, Kuaile Lin, and Weicheng Zhou Source Type: research

[ASAP] Optimized Synthesis of Indole Carboxylate Metallo- β-Lactamase Inhibitor EBL-3183
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00002 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - March 30, 2023 Category: Chemistry Authors: Andrei Baran, Jevgenijs Kuzmins, Jevgenijs Kuznecovs, Alistair J. M. Farley, Tharindi Panduwawala, Anete Parkova, Pavel A. Donets, Ju ̈rgen Brem, Edgars Suna, Christopher J. Schofield, and Kirill Shubin Source Type: research

[ASAP] Advanced In-Line Purification Technologies in Multistep Continuous Flow Pharmaceutical Synthesis
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00374 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - March 30, 2023 Category: Chemistry Authors: Zhexuan Lei, Hwee Ting Ang, and Jie Wu Source Type: research

[ASAP] Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 1: Azidation and [3 + 2] Cycloaddition
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00035 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - March 30, 2023 Category: Chemistry Authors: Peter Sagmeister, Michael Prieschl, Dainis Kaldre, Chethana Gadiyar, Christian Moessner, Joerg Sedelmeier, Jason D. Williams, and C. Oliver Kappe Source Type: research

[ASAP] Toward a Combined Molecular Dynamics and Quantum Mechanical Approach to Understanding Solvent Effects on Chemical Processes in the Pharmaceutical Industry: The Case of a Lewis Acid-Mediated S < sub > N < /sub > Ar Reaction
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00010 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - March 29, 2023 Category: Chemistry Authors: Gerald J. Tanoury, Satish Kumar Iyemperumal, and Elaine C. Lee Source Type: research

[ASAP] Development of the Methodology for < italic toggle="yes" > in Silico < /italic > Reactivity-Based Purge Predictions: Making Mirabilis Think Like a Chemist
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00003 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - March 29, 2023 Category: Chemistry Authors: James A. McManus, Roci ́o Lopez-Rodríguez, Natasha S. Murphy, Lara James, Daniel C. O’Connor, Georgina C. Gavins, and Michael J. Burns Source Type: research

[ASAP] Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 2: Cyclization, Chlorination, and Amination
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00036 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - March 29, 2023 Category: Chemistry Authors: Michael Prieschl, Peter Sagmeister, Christian Moessner, Joerg Sedelmeier, Jason D. Williams, and C. Oliver Kappe Source Type: research

[ASAP] Scalable, Green Synthesis of Heteroaromatic Amine-boranes
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00031 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - March 28, 2023 Category: Chemistry Authors: P. Veeraraghavan Ramachandran, Henry J. Hamann, Randy Lin, and Aman Singh Source Type: research

[ASAP] Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00009 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - March 24, 2023 Category: Chemistry Authors: Fredrik L. Nordstrom, Eric Sirota, Clara Hartmanshenn, Thomas T. Kwok, Mitchell Paolello, Huayu Li, Vincent Abeyta, Tommasina Bramante, Emma Madrigal, Taylor Behre, and Gerard Capellades Source Type: research

[ASAP] Photocatalytic and Photoinduced Phosphonylation of Aryl Iodides: A Batch and Flow Study
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00379 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - March 24, 2023 Category: Chemistry Authors: Romain Lapierre, Thi Minh Thi Le, Bruno Schiavi, Damien Thevenet, Marc Bazin, Ryan Buzdygon, Philippe Jubault, and Thomas Poisson Source Type: research

[ASAP] Case Studies in the Application of a Workflow-Based Crystallization Design for Optimized Impurity Rejection in Pharmaceutical Development
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00346 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - March 24, 2023 Category: Chemistry Authors: Paridhi Agrawal, Saurin H. Rawal, Venkata Ramana Reddy, Shekhar K. Viswanath, and Jeremy M. Merritt Source Type: research