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[ASAP] Pilot-Scale Synthesis and Purification of α‑Asaronol for Antiepileptic Drug Development
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00076 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 13, 2023 Category: Chemistry Authors: Qun-Zheng Zhang, Zhi-Qiang Ouyang, Yu-Hao Zhou, Si-Chang Wang, Cong-Yu Ke, Ya-Jun Bai, Xun-Li Zhang, and Xiao-Hui Zheng Source Type: research

[ASAP] Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00135 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 9, 2023 Category: Chemistry Authors: Thomas Hilberath, Remco van Oosten, Juliet Victoria, Hugo Brasselet, Miguel Alcalde, John M. Woodley, and Frank Hollmann Source Type: research

[ASAP] Densely Packed Chemical Synthesis Equipment by 3D Spatial Design and Additive Manufacturing: Acetylene Generation Cartridge
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00112 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 7, 2023 Category: Chemistry Authors: Kirill S. Erokhin and Valentine P. Ananikov Source Type: research

[ASAP] Correction to “Safety Considerations and Proposed Workflow for Laboratory Scale Chemical Synthesis by Ball Milling”
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00155 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 7, 2023 Category: Chemistry Authors: Ian Priestley, Claudio Battilocchio, Andrei Iosub, Fabien Barreteau, Gavin W. Bluck, Kenneth B. Ling, Katharine Ingram, Maria Ciaccia, Jamie A. Leitch, and Duncan L. Browne Source Type: research

[ASAP] Correction to “Development of a Quality Risk Based Tool for the Selection of Regulatory Starting Materials for Commercial Drug Substance Manufacturing Processes”
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00173 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 7, 2023 Category: Chemistry Authors: John Lepore, Tariq Mahmood, and Robert Hartman Source Type: research

[ASAP] Development of a Chromane-Forming Heck Reaction: Bisphosphine Mono-Oxide Mediated Regioselectivity Perturbed by Solvent-Based Peroxide Formation
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00105 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 7, 2023 Category: Chemistry Authors: Adrian Doggett, Michael Hay, Shane McKenna, Eric M. Saurer, Sarah Steinhardt, Yichen Tan, Christopher R. Wilbert, and Steven R. Wisniewski Source Type: research

[ASAP] Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00029 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 7, 2023 Category: Chemistry Authors: Szebasztia ́n Szaniszló, Kristóf Ferentzi, András Perczel, and Viktor Farkas Source Type: research

[ASAP] Identifying the Risk of Formation of Nitrosamines and Other Potentially Mutagenic Impurities during API Manufacture Using < italic toggle="yes" > In Silico < /italic > Risk Assessment
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00118 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 6, 2023 Category: Chemistry Authors: Natasha S. Murphy, Daniel C. O ’Connor, Georgina C. Gavins, Lara James, Jonathan P. Lockett, James A. McManus, Gemma Packer, Rocío Lopez-Rodríguez, Samuel J. Webb, and Michael J. Burns Source Type: research

[ASAP] Some Items of Interest to Process R & D Chemists and Engineers
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00176 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 6, 2023 Category: Chemistry Authors: James A. Schwindeman, David S. B. Daniels, James J. Douglas, Alex Kosanovich, Christopher B. Kelly, Timothy Kwok, Sylvain Guizzetti, and John Knight Source Type: research

[ASAP] Novel, Practical, and Scalable Approach for the Synthesis of Eldecalcitol
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00369 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 6, 2023 Category: Chemistry Authors: Ai-ping Chen, Ren-xiang Tan, Xiao-long Jiang, Hai-feng Ji, Lei Li, Jian Zhou, Xian-kai Meng, Zhen-jiang Tong, Yan-cheng Yu, and Xiao-long Wang Source Type: research

[ASAP] Scale-Up Synthesis of Site-Specific Antibody –Drug Conjugates Using AJICAP Second-Generation Technology
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00111 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 6, 2023 Category: Chemistry Authors: Tomohiro Watanabe, Tomohiro Fujii, Jason T. Stofleth, Rika Takasugi, Kazutoshi Takahashi, and Yutaka Matsuda Source Type: research

[ASAP] Improved Synthetic Process of Baloxavir Marboxil Intermediate 3 ‑Benzyloxy-4-oxo‑4 < italic toggle="yes" > H < /italic > ‑pyran-2-carboxylic Acid
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00387 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 2, 2023 Category: Chemistry Authors: Kongcheng Huang, Jianwu Lu, Xiaoxu Wang, Yinfei Shi, Kaimike Yang, Shun Yuan, Yinquan Wang, Han Sun, Yuebin Liu, Xun Sun, and Taizhi Wu Source Type: research

[ASAP] Thermal Behavior and Decomposition Pathway for Nitrophenols and Sodium Nitrophenolates
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00403 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 2, 2023 Category: Chemistry Authors: Shichun Weng, Wei Feng, Wenqian Wu, Zichao Guo, Liping Chen, and Wanghua Chen Source Type: research

[ASAP] Coaxial Dielectric Spectroscopy as an In-Line Process Analytical Technique for Reaction Monitoring
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00081 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - May 30, 2023 Category: Chemistry Authors: Desiree M. Dalligos, Michael J. Pilling, Georgios Dimitrakis, and Liam T. Ball Source Type: research

[ASAP] Approaches and Considerations for the Investigation and Synthesis of < italic toggle="yes" > N < /italic > ‑Nitrosamine Drug Substance-Related Impurities (NDSRIs)
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.3c00084 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - May 30, 2023 Category: Chemistry Authors: Ian W. Ashworth, Alexander Blanazs, Jonathan J. Byrne, Olivier Dirat, Jared W. Fennell, Nadine Kuhl, Stuart L. Wells, and Matthew P. Whiting Source Type: research