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[ASAP] pH-Switchable Phase-Transfer Agents for Host Cell Protein Rejection in the Cascaded Biocatalytic Synthesis of an Active Pharmaceutical Ingredient
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00327 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 22, 2022 Category: Chemistry Authors: Matthew S. Winston, Marc Poirier, Zhijian Liu, Feng Peng, Guy R. Humphrey, John A. McIntosh, Mikhail Reibarkh, Fengqiang Wang, Erik D. Guetschow, Steve Castro, Erik Hoyt, David J. Lamberto, and Kevin Sirk Source Type: research

[ASAP] Opportunities for the Application and Advancement of the Corey –Chaykovsky Cyclopropanation
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00315 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 21, 2022 Category: Chemistry Authors: Gregory L. Beutner and David T. George Source Type: research

[ASAP] Optimized Synthesis of a Key Intermediate of Nirmatrelvir
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00225 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 20, 2022 Category: Chemistry Authors: Hongjian Qin, Chen Jin, Abdullajon Odilov, Emmanuel Mintah Bonku, Fuqiang Zhu, Qi Liu, Jingshan Shen, and Haji A. Aisa Source Type: research

[ASAP] Safer and Convenient Synthesis of 3,4-Bis(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole-2-oxide (BNFF/DNTF)
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00250 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 19, 2022 Category: Chemistry Authors: Yuangang Xu, Shuaiqi Wang, Dongxue Li, Pengcheng Wang, Qiuhan Lin, and Ming Lu Source Type: research

[ASAP] Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture What a Difference a Base Makes
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00332 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 19, 2022 Category: Chemistry Authors: James I. Murray, Liang Zhang, Adam Simon, Maria V. Silva Elipe, Carolyn S. Wei, Seb Caille, and Andrew T. Parsons Source Type: research

[ASAP] Scalable Process of Methimazole
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00185 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 15, 2022 Category: Chemistry Authors: Ramesh Goura, Surendra Babu Manubolu Surya, Naresh Kumar Katari, Ramprasad Achampeta Kodanda, and Pradeep Rebelly Source Type: research

[ASAP] Continuous Process to Safely Manufacture an Aryldiazoacetate and Its Direct Use in a Dirhodium-Catalyzed Enantioselective Cyclopropanation
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00288 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 14, 2022 Category: Chemistry Authors: Stephen P. Lathrop, Laurie B. Mlinar, Onkar N. Manjrekar, Yong Zhou, Kaid C. Harper, Eric R. Sacia, Molly Higgins, Andrew R. Bogdan, Zhe Wang, Steven M. Richter, Wei Gong, Eric A. Voight, Jeremy Henle, Moiz Diwan, Jeffrey M. Kallemeyn, Jack C. Sharland, B Source Type: research

[ASAP] Refractive Index to Monitor Solid-Phase Oligonucleotide Synthesis
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00203 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 14, 2022 Category: Chemistry Authors: Tobias Heilmann, Damian Ackermann, and John Lopez Source Type: research

[ASAP] Modified Greener Procedure for the Synthesis of Cucurbit[6]uril
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00308 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 13, 2022 Category: Chemistry Authors: Oleksandr Zbruyev, Konstantin Belikov, Serhii Khimchenko, Tamara Blank, and Valentyn A. Chebanov Source Type: research

[ASAP] Early Process Development and Scale-Up of Orally Active Apomorphine Drug Candidates
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00297 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 12, 2022 Category: Chemistry Authors: Ekaterina Y. Melikhova, Nolwenn Derrien, Nadia Fleary-Roberts, Sia ̂n M. Forsyth, Sofia Papadouli, Antonio M. Ruda, Vargini G. Thangavadivale, Simon N. G. Tyler, and Jonathan D. Moseley Source Type: research

[ASAP] Inert Gassing Crystallization for Improved Product Separation of Oleo-Chemicals toward an Efficient Circular Economy
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00312 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 9, 2022 Category: Chemistry Authors: Astrid I. Seifert, Justin Simons, Jan Gutsch, and Kerstin Wohlgemuth Source Type: research

[ASAP] The Role of Solvent Hydroxyl Functional Groups on the Interaction Energy and Growth of Form I Paracetamol Crystal Facets
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00151 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 7, 2022 Category: Chemistry Authors: Nurshahzanani Shahrir, Nornizar Anuar, Nur Aisyah Abdul Muttalib, Siti Nurul ’ain Yusop, Mohd. Rushdi Abu Bakar, Fatmawati Adam, and Siti Fatimah Ibrahim Source Type: research

[ASAP] Digital Design of Filtration and Washing of Active Pharmaceutical Ingredients via Mechanistic Modeling
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00165 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 6, 2022 Category: Chemistry Authors: Sara Ottoboni, Cameron J. Brown, Bhavik Mehta, Guillermo Jimeno, Niall A. Mitchell, Jan Sefcik, and Chris J. Price Source Type: research

[ASAP] Development of Commercial Manufacturing Processes for Acalabrutinib
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00304 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 6, 2022 Category: Chemistry Authors: Paul A. Bethel, Lai Chun Chan, Katie Cooper, Gareth J. Ensor, Jerry Evarts, Rustam Garrey, J. Gair Ford, Daniel Harding, Shaun Hughes, Lucy Jackson, Michael Golden, Kirsty Millard, Andrew Phillips, Andrew Robbins, David Short, Alex Telford, and David T. E Source Type: research

[ASAP] Development of a Scalable Route for a Key Benzothiazole Building Block via a Pd-Catalyzed Migita Coupling with a Nonsmelly Thiol Surrogate
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00331 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - December 6, 2022 Category: Chemistry Authors: Gabriel Scha ̈fer, Aurélien Merot, and Tony Fleischer Source Type: research