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[ASAP] Development of a Robust and Scalable Synthetic Route for a Potent and Selective Isoindolinone PI3K γ Inhibitor
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00240 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 28, 2022 Category: Chemistry Authors: Artur K. Mailyan, Guillaume Mata, Dillon H. Miles, Ehesan U. Sharif, Manmohan R. Leleti, Jay P. Powers, and Jenna L. Jeffrey Source Type: research

[ASAP] Development of an Efficient New Route to PPAR δ Agonist Fonadelpar: Formation of the C–C Bond by Claisen Condensation
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00235 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 23, 2022 Category: Chemistry Authors: Min Huang, Manman Sun, Lanxin Zhang, Xuebo Yang, Yuntao Shi, Kun Xing, Hongguang Deng, Zhenwei Zhang, Dan Liu, and Linxiang Zhao Source Type: research

[ASAP] Mathematical Modeling and Optimization to Inform Impurity Control in an Industrial Active Pharmaceutical Ingredient Manufacturing Process
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00208 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 21, 2022 Category: Chemistry Authors: Samir Diab, Charalampos Christodoulou, George Taylor, and Philip Rushworth Source Type: research

[ASAP] Reliable Calorimetric Method to Study the Incompatibilities between Hydrazine Hydrate and Metallic Impurities
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00236 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 19, 2022 Category: Chemistry Authors: Jialei Gu, Yingtao Tian, Xingmin Zhang, Marian Lanz, Pascale Hoehn, Luisa Heinz, Ernesto Santandrea, Guido Jordine, Xigui Jiang, Hao Zhang, Liangxing Wang, Chongfeng Pan, Fengfeng Guo, and Jialiang Li Source Type: research

[ASAP] Continuous Formation of Limonene Carbonates in Supercritical Carbon Dioxide
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00143 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 16, 2022 Category: Chemistry Authors: Philipp Miks ̌ovsky, Elias N. Horn, Shaghayegh Naghdi, Dominik Eder, Michael Schnürch, and Katharina Bica-Schröder Source Type: research

[ASAP] < italic toggle="yes" > tert < /italic > -Butylethylcarbodiimide as an Efficient Substitute for Diisopropylcarbodiimide in Solid-Phase Peptide Synthesis: Understanding the Side Reaction of Carbodiimides with OxymaPure
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00220 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 9, 2022 Category: Chemistry Authors: Srinivasa Rao Manne, Damilola Caleb Akintayo, Omar Luna, Ayman El-Faham, Beatriz G. de la Torre, and Fernando Albericio Source Type: research

[ASAP] Multigram Synthesis of Pure HMF and BHMF
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00196 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 9, 2022 Category: Chemistry Authors: Giacomo Trapasso, Giovanna Mazzi, Beatriz Chi ́charo, Mattia Annatelli, Davide Dalla Torre, and Fabio Aricò Source Type: research

[ASAP] Preparation of Enantiopure 3 ‑Aminopiperidine and 3‑Aminoazepane Derivatives from Ornithine and Lysine. Consecutive Syntheses of Pharmacologically Active Analogs, Such as Besifloxacin
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00152 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 9, 2022 Category: Chemistry Authors: Ingo Schiffers, Marcus Frings, Britta Maria Ku ̈bber, Khai-Nghi Truong, Kari Rissanen, and Carsten Bolm Source Type: research

[ASAP] Green Chemistry Articles of Interest to the Pharmaceutical Industry
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00274 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 6, 2022 Category: Chemistry Authors: Marian C. Bryan, Charlotte Dalton, Jaika Doerfler, Oliver D. Engl, Paul Ferguson, Alejandro Gimenez Molina, Vanessa Harawa, Joseph Hosford, Gareth P. Howell, Christopher B. Kelly, Wei Li, Rachel H. Munday, Antonio Navarro, Michael Parmentier □, Jan Pawl Source Type: research

[ASAP] Thermal Safety and Structure-Related Reactivity Investigation of Five-Membered Cyclic Sulfamidates
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00130 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 6, 2022 Category: Chemistry Authors: Thomas Ferrari, Caitlin Blum, Lara Amini-Rentsch, Pierre Brodard, Michal Dabros, Pascale Hoehn, Aniko ́ Udvarhelyi, Roger Marti, and Michaël Parmentier Source Type: research

[ASAP] Biobased 2,5-Dimethyltetrahydrofuran as a Green Aprotic Ether Solvent
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00136 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 2, 2022 Category: Chemistry Authors: Chen Zhang, Yufen Wang, Weiran Yang, and Jing Zheng Source Type: research

[ASAP] Development, Validation, and Application of a Custom-Made Mini-Reaction Calorimeter for Thermal Safety Screening
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00128 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 2, 2022 Category: Chemistry Authors: Caitlin Blum, Lara Amini-Rentsch, Thomas Ferrari, Pierre Brodard, Roger Marti, Pascale Hoehn, Michal Dabros, and Michae ̈l Parmentier Source Type: research

[ASAP] Synthesis and Applications of Periodate for Fine Chemicals and Important Pharmaceuticals
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00161 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 1, 2022 Category: Chemistry Authors: Sebastian Arndt, Philipp J. Kohlpaintner, Kai Donsbach, and Siegfried R. Waldvogel Source Type: research

[ASAP] Some Items of Interest to Process R & D Chemists and Engineers
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00262 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 1, 2022 Category: Chemistry Authors: Paul F. Richardson, Alan Steven, Robert B. Kargbo, Carlos Mateos, Andrei A. Zlota, Christopher C. Nawrat, Rik Oost, and John Knight Source Type: research

[ASAP] Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C –N Coupling
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00221 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - September 1, 2022 Category: Chemistry Authors: Bo Qu, Jaehee Lee, Lifen Wu, Anjan K. Saha, Guisheng Li, Yibo Xu, Zhulin Tan, Jason Brazzillo, Nizar Haddad, Scott Pennino, Sonia Rodriguez, Jon C. Lorenz, Rogelio Frutos, Kanwar P. S. Sidhu, Xiao-Jun Wang, Yongda Zhang, Chris H. Senanayake, and Jinhua J. Source Type: research