Contents
Julie G. Pilitsis and Joshua M. Rosenow (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - June 17, 2022 Category: Neurosurgery Source Type: research

Forthcoming Issues
Update on Open Vascular Surgery (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - June 17, 2022 Category: Neurosurgery Source Type: research

Nonopioid Postoperative Pain Management in Neurosurgery
Neurosurgeons have sought to minimize the use of opioids in neurosurgery. Preoperative medical strategies include methadone and gabapentinoids. Intraoperative strategies include local anesthetic infiltration with bupivacaine, ropivacaine, and lidocaine; scalp block; steroids such as methylprednisolone, triamcinolone, and dexamethasone; ketamine; acetaminophen; ketorolac; liposomal bupivacaine; dexmedetomidine; and performing awake surgery. Postoperative strategies include continuous infusion pumps, wound catheters, and patient-controlled analgesia. Multimodal analgesia may be most effective, with the enhanced recovery afte...
Source: Neurosurgery Clinics of North America - May 26, 2022 Category: Neurosurgery Authors: Nathan A. Shlobin, Joshua M. Rosenow Source Type: research

Spinal Cord Stimulation
The efficacy of spinal cord stimulation for treating chronic pain has encouraged the development of a wide variety of different technologies for stimulation. In this review, the authors first discuss how parameters of stimulation determine the stimulation waveform. They then discuss new stimulation waveforms, including high frequency and burst stimulation, and the evidence supporting their use. Finally, the authors turn to emerging technologies and techniques including dorsal root ganglion stimulation, wireless stimulation, and closed-loop stimulation. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - May 26, 2022 Category: Neurosurgery Authors: Dennis London, Alon Mogilner Source Type: research

Closed-Loop Systems in Neuromodulation
Most currently available neuromodulation techniques for pain work through an open-loop system. The distance between the epidural space and the target of the stimulation in a dynamic body can change because of physiologic conditions. The closed-loop system in spinal cord neuromodulation consists of an integrated system that records real-time electrophysiological activity in the form of evoked compound action potentials and uses it in a feedback mechanism to adjust stimulus output. Wearables represent newly developed technologies that have gained traction in recent years. Their application in pain management is still develop...
Source: Neurosurgery Clinics of North America - May 26, 2022 Category: Neurosurgery Authors: Thiago S. Montenegro, Rushna Ali, Jeffrey E. Arle Source Type: research

What ’s New in Peripheral Nerve Stimulation
This article provides an overview of recent advances in this field. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - May 26, 2022 Category: Neurosurgery Authors: Hart P. Fogel, Christopher J. Winfree Source Type: research

The Multidisciplinary Team in Pain Management
A multidisciplinary approach to pain management includes evaluation by a variety of healthcare professionals who possess differing levels of expertise and who often consult with one another. The “core” multidisciplinary team commonly consists of primary care providers, anesthesiologists, psychologists, nurses, and physical and occupational therapists, with additional involvement from surgeons, neurologists, internists, physiatrists, psychiatrists, social workers, dietitians, and pharmac ists. Multiple studies have supported the use of multidisciplinary programs as effective, cost-efficient, and superior to single-disci...
Source: Neurosurgery Clinics of North America - May 25, 2022 Category: Neurosurgery Authors: Michael D. Staudt Source Type: research

Health Care Disparity in Pain
Disparity in the treatment of chronic pain has become increasingly pertinent in health care, given the large burden of disease and its economic costs to society. That disease burden is disproportionally carried by minorities and those of lower socioeconomic status for a host of historical and systemic reasons. Only by understanding the cause of such disparities, collecting accurate and thorough data that illuminate all contributing factors, and diversifying the health care workforce, can we achieve more equitable treatment and reduce the burden of chronic pain. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - May 25, 2022 Category: Neurosurgery Authors: Travis M. Hamilton, Jared C. Reese, Ellen L. Air Source Type: research

The Role of Intrathecal Pumps in Nonmalignant Pain
Intrathecal pumps deliver analgesic medication directly into the central nervous system. In patients with chronic nonmalignant pain, intrathecal therapy using morphine or ziconotide has been shown to be an effective option when traditional noninvasive methods do not provide adequate relief. There has been increasing use of intrathecal drug administration in the management of patients with nonmalignant pain in recent years given the advances in technology and research on the topic. However, due to its invasive nature, intrathecal pumps remain the last option among patients with chronic pain. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - May 25, 2022 Category: Neurosurgery Authors: Elizabeth E. Ginalis, Saim Ali, Antonios Mammis Source Type: research

Focused Ultrasound for Chronic Pain
Chronic pain affects millions of Americans and is one of the leading reasons for individuals to seek medical attention. Focused ultrasound has been studied as a noninvasive treatment option for various pain disorders. Current studies have used focused ultrasound for ablation, neuromodulation, and opening of the blood-brain barrier for drug and therapy delivery. Most of the work has been performed in ablative studies and has shown efficacy in treating chronic neuropathic pain. Further research is needed to expand its usage in neurosurgery. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - May 25, 2022 Category: Neurosurgery Authors: Jonathan Bao, Thomas Tangney, Julie G. Pilitsis Source Type: research

Imaging as a Pain Biomarker
In recent years, the hunt for objective biomarkers in chronic pain has intensified, as interest has grown in precision medicine techniques, and the global opioid crisis has underscored the need to accelerate the pace of pain research. A growing body of neuroimaging literature suggests that chronic pain is associated with various alterations in regional brain areas as well as whole-brain networks, which may represent unique radiological pain signatures or biomarkers to guide diagnosis, response, and treatment. Here, we provide a comprehensive and updated literature review on investigative efforts to identify neuroimaging bi...
Source: Neurosurgery Clinics of North America - May 25, 2022 Category: Neurosurgery Authors: Alon Kashanian, Evangelia Tsolaki, James Caruso, Ausaf Bari, Nader Pouratian Source Type: research

Machine Learning and Pain Outcomes
This article provides an overview of ML and its applications within the pain field. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - May 25, 2022 Category: Neurosurgery Authors: Tessa Harland, Amir Hadanny, Julie G. Pilitsis Source Type: research

Deep Brain Stimulation for Chronic Pain
Deep brain stimulation (DBS) is a neurosurgical intervention well known for the treatment of movement disorders as well as epilepsy, Tourette syndrome, and obsessive-compulsive disorders. DBS was pioneered in the 1950s, however, as a tool for treating facial pain, phantom limb pain, post-stroke pain, and brachial plexus pain among other disease states. Various anatomic targets exist, including the sensory thalamus (ventral posterior lateral and ventral posterior medial), the periaqueductal gray and periventricular gray matter, and the anterior cingulate cortex. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - May 25, 2022 Category: Neurosurgery Authors: Alexander Alamri, Erlick A.C. Pereira Source Type: research

Financial Sustainability of Neuromodulation for Pain
When considering the financial sustainability of neuromodulation for pain, one needs to consider the varying costs involved with this therapy. These include comparisons between different types of neuromodulation, comparisons between neuromodulation and conventional therapy, and comparisons between neuromodulation and other invasive modalities. In addition, any consideration of cost also needs to take quality into account. Even if a therapy is expensive, it can be considered cost-effective if it leads to significant increase in quality of life and economic productivity of the patient. This review considers these questions, ...
Source: Neurosurgery Clinics of North America - May 25, 2022 Category: Neurosurgery Authors: Jason M. Schwalb Source Type: research

Advances in Pain Management
Recent events have highlighted the need for better management of chronic pain. Pain is one of the most common reasons for an individual to visit the emergency room and one of the most common reasons for surgery. Neurosurgeons are often performing procedures for the purposes of managing pain, whether that be radiculopathy, trigeminal neuralgia, chronic regional pain syndrome, or peripheral nerve entrapment. This issue of Neurosurgery Clinics of North America explores multiple diverse aspects of neurosurgical pain care. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - May 25, 2022 Category: Neurosurgery Authors: Julie G. Pilitsis, Joshua M. Rosenow Tags: Preface Source Type: research