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Contributors
RUSSELL R. LONSER, MD (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - May 19, 2023 Category: Neurosurgery Source Type: research

Contents
Randy L. Jensen and Gabriel Zada (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - May 19, 2023 Category: Neurosurgery Source Type: research

Forthcoming Issues
Spinal Deformity Update (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - May 19, 2023 Category: Neurosurgery Source Type: research

Transcavernous Approach in Vascular Neurosurgery
The cavernous sinus is no more considered no man's land. It is a very well organized anatomic entity that can safely be navigated. It is both a route and a destination. Unlocking the cavernous sinus provides a highway that can be used to reach different vascular and tumor locations that were deemed very risky to handle. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - May 8, 2023 Category: Neurosurgery Authors: Ali F. Krisht, Jaafar Basma, Li Cai Source Type: research

Management of Intraventricular Meningiomas
Intraventricular meningiomas (IVM) are intracranial tumors that originate from collections of arachnoid cells within the choroid plexus. The incidence of meningiomas is estimated to be about 97.5 per 100,000 individuals in the United States with IVMs constituting 0.7% to 3%. Positive outcomes have been observed with surgical treatment of intraventricular meningiomas. This review explores elements of surgical care and management of patients with IVM, highlighting nuances in surgical approaches, their indications, and considerations. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - April 18, 2023 Category: Neurosurgery Authors: Michael A. Bamimore, Lina Marenco-Hillembrand, Krishnan Ravindran, David Agyapong, Elena Greco, Erik H. Middlebrooks, Kaisorn L. Chaichana Source Type: research

Management of Atypical and Anaplastic Meningiomas
This article provides an overview of atypical and anaplastic “malignant” meningiomas, their treatment, and ongoing research looking for more effective treatments. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - April 18, 2023 Category: Neurosurgery Authors: Dominique Higgins, Ashish H. Shah, Ricardo J. Komotar, Michael E. Ivan Source Type: research

Meningiomas: An Update on Diagnostic and Therapeutic Approaches
Meningiomas are among the most common intracranial tumors. Despite their relatively benign nature, multimodal treatment is often required to treat them because of their invasive nature, varying location, and lack of medical or chemotherapy availability. Advances in imaging, diagnostics, and therapeutics have improved the contemporary care of patients with meningiomas over the past decade. In this issue, we examine the contemporary updates in genomics, epigenomics, pathologic diagnosis, imaging, medical management, and surgical approaches used to treat meningiomas. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - April 18, 2023 Category: Neurosurgery Authors: Randy L. Jensen, Gabriel Zada Tags: Preface Source Type: research

Medical Management of Meningiomas
Meningiomas represent the most common type of benign tumor of the extra-axial compartment. Although most meningiomas are benign World Health Organization (WHO) grade 1 lesions, the increasingly prevalent of WHO grade 2 lesion and occasional grade 3 lesions show worsened recurrence rates and morbidity. Multiple medical treatments have been evaluated but show limited efficacy. We review the status of medical management in meningiomas, highlighting successes and failures of various treatment options. We also explore newer studies evaluating the use of immunotherapy in management. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - April 12, 2023 Category: Neurosurgery Authors: Mohammed A. Azab, Kyril Cole, Emma Earl, Chris Cutler, Joe Mendez, Michael Karsy Source Type: research

Spinal Meningiomas
Meningiomas of the spinal canal are the most common intradural spinal canal tumors encountered in adults and account for 8% of all meningiomas. Patient presentation can vary considerably. Once diagnosed, these lesions are primarily treated surgically, but depending on location and pathological features, chemotherapy and radiosurgery may be required. Emerging modalities may represent adjuvant therapies. In this article, we review the current management of meningiomas of the spinal column. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - April 12, 2023 Category: Neurosurgery Authors: Vijay M. Ravindra, Meic H. Schmidt Source Type: research

Endovascular Embolization of Intracranial Meningiomas
Although benign in histology, the hypervascularity and skull base location of meningiomas can make them surgically challenging lesions. Preoperative endovascular embolization with superselective microcatheterization of vascular pedicles may be efficacious in decreasing intraoperative transfusion requirements with equivocal postoperative functional benefit. The potential benefits of preoperative embolization should be weighed against the risks of ischemic complications. Appropriate patient selection is critical. All patients should be monitored closely postembolization, and a course of steroids can be considered to minimize...
Source: Neurosurgery Clinics of North America - April 12, 2023 Category: Neurosurgery Authors: Michelle Lin, Vincent Nguyen, William J. Mack Source Type: research

Incidental Meningiomas
The rise in availability of neuroimaging has led to an increase in incidentally discovered meningiomas. These tumors are typically asymptomatic and tend to display slow growth. Treatment options include observation with serial monitoring, radiation, and surgery. Although optimal management is unclear, clinicians recommend a conservative approach, which preserves quality of life and limits unnecessary intervention. Several risk factors have been investigated for their potential utility in the development of prognostic models for risk assessment. Herein, the authors review the current literature on incidental meningiomas, fo...
Source: Neurosurgery Clinics of North America - April 12, 2023 Category: Neurosurgery Authors: Natalie Mahgerefteh, Khashayar Mozaffari, Zoe Teton, Yelena Malkhasyan, Kihong Kim, Isaac Yang Source Type: research

Modeling Meningiomas
Preclinical meningioma models offer a setting to test molecular mechanisms of tumor development and targeted treatment options but historically have been challenging to generate. Few spontaneous tumor models in rodents have been established, but cell culture and in  vivo rodent models have emerged along with artificial intelligence, radiomics, and neural networks to differentiate the clinical heterogeneity of meningiomas. We reviewed 127 studies using PRISMA guideline methodology, including laboratory and animal studies, that addressed preclinical modeling. O ur evaluation identified that meningioma preclinical models pro...
Source: Neurosurgery Clinics of North America - April 10, 2023 Category: Neurosurgery Authors: Majid Khan, Chadwin Hanna, Matthew Findlay, Brandon Lucke-Wold, Michael Karsy, Randy L. Jensen Source Type: research

Open Surgical Approaches for Meningiomas
This article summarizes various craniotomies and their approaches to meningiomas, and illustrates some nuances in performing these techniques with cadaveric dissection and operative videos. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - April 7, 2023 Category: Neurosurgery Authors: Xiaochun Zhao, Sherwin A. Tavakol, Panayiotis E. Pelargos, Ali H. Palejwala, Ian F. Dunn Source Type: research

Stereotactic Radiosurgery for Intracranial Meningiomas
Meningiomas are thought to originate from the meningothelial cells of the arachnoid mater and are the most common primary brain tumor in adults. Histologically confirmed meningiomas occur with an incidence of 9.12/100,000 population and account for 39% of all primary brain tumors and 54.5% of all non-malignant brain tumors. Risk factors for meningioma include age 65 years and older, female gender, African-American race, history of exposure to head and neck ionizing radiation, and certain genetic disorders such as neurofibromatosis II. Intracranial meningiomas are the most commonly benign, WHO Grade I neoplasms. Atypical an...
Source: Neurosurgery Clinics of North America - April 7, 2023 Category: Neurosurgery Authors: Stylianos Pikis, Georgios Mantziaris, Chloe Dumot, Zhiyuan Xu, Jason Sheehan Source Type: research

Spheno-Orbital Meningiomas
Meningiomas are the most common intracranial brain tumor. Spheno-orbital meningiomas are a rare subtype that originate at the sphenoid wing and characteristically extend to the orbit and surrounding neurovascular structures via bony hyperostosis and soft tissue invasion. This review summarizes early characterizations of spheno-orbital meningiomas, presently understood tumor characteristics, and current management strategies. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - April 5, 2023 Category: Neurosurgery Authors: Cameron A. Rawanduzy, Karol P. Budohoski, Robert C. Rennert, Alexander Winkler-Schwartz, William T. Couldwell Source Type: research