Sleep quality, excessive daytime sleepiness, and depression in Parkinson's disease: implications for improved patient outcomes
DISCUSSION: Addressing the specific etiology of sleep disorders in Parkinson's patients has the potential to result in improved treatment outcomes and enhanced functionality in their daily lives.PMID:38264903 | DOI:10.1080/01616412.2024.2301878 (Source: Neurological Research)
Source: Neurological Research - January 24, 2024 Category: Neurology Authors: Esma Kobak Tur Mehmet Demir G ülay Kenangil F üsun Mayda Domaç Source Type: research
Agents at the Peak of US FDA Approval for the Treatment of Alzheimer's Disease
Neurol Res. 2024 Jan 10:1-8. doi: 10.1080/01616412.2024.2302271. Online ahead of print.ABSTRACTWhere Alzheimer's disease (AD) is becoming a global health issue, the present anti-AD medications have also been exposed to produce only symptomatic outcomes. The pathological factors, like neuronal transmission impairment, amyloidal-tau constituents, oxidative damage, neuro-inflammation, synaptic dysfunction, infectious agents, and impairment of gut microbiota and vitamins' levels; all favor the disease's progression and sustainability. The researchers have investigated several drugable molecules against these factors; however, ...
Source: Neurological Research - January 10, 2024 Category: Neurology Authors: Jahngeer Alam Anushka Kalash Md Imtaiyaz Hassan Syed Ziaur Rahman Source Type: research
Optimization of a translational murine model of closed-head traumatic brain injury
Neurol Res. 2024 Jan 10:1-14. doi: 10.1080/01616412.2024.2302261. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) from closed-head trauma is a leading cause of disability, with limited effective interventions. Many TBI models impact brain parenchyma directly, and are limited by the fact that these forces do not recapitulate clinically relevant closed head injury. However, applying clinically relevant injury mechanics to the intact skull may lead to variability and as a result, preclinical modeling TBI remains a challenge. Current models often do not explore sex differences in TBI, which is critically important f...
Source: Neurological Research - January 10, 2024 Category: Neurology Authors: Brian E Mace Eric Lassiter Evangeline Kamalini Arulraja Eduardo Chaparro Viviana Cantillana Rupali Gupta Timothy D Faw Daniel T Laskowitz Brad J Kolls Source Type: research
Efficacy and safety of pregabalin vs carbamazepine in patients with central post-stroke pain
CONCLUSIONS: Pregabalin, but not carbamazepine, may be effective in improving F-VAS, HAMA and HAMD in patients with CPSP.PMID:38192206 | DOI:10.1080/01616412.2024.2302269 (Source: Neurological Research)
Source: Neurological Research - January 9, 2024 Category: Neurology Authors: Hongyan Xu Mingjian Guan YuFeng Chen Haoqiang Qin Shuilan Huang Source Type: research
Efficacy and safety of pregabalin vs carbamazepine in patients with central post-stroke pain
CONCLUSIONS: Pregabalin, but not carbamazepine, may be effective in improving F-VAS, HAMA and HAMD in patients with CPSP.PMID:38192206 | DOI:10.1080/01616412.2024.2302269 (Source: Neurological Research)
Source: Neurological Research - January 9, 2024 Category: Neurology Authors: Hongyan Xu Mingjian Guan YuFeng Chen Haoqiang Qin Shuilan Huang Source Type: research
Memory impairment induced by aluminum nanoparticles is associated with hippocampal IL-1 and IBA-1 upregulation in mice
DISCUSSION: These findings indicate that the memory impairing effect of Al-NP coincides with hippocampal inflammation. According to the proposed relationship between AD and Al toxicity, this study can increase the knowledge about the toxic effects of Al-NP and highlight the need to limit the use of this nanoparticle.PMID:38145565 | DOI:10.1080/01616412.2023.2298137 (Source: Neurological Research)
Source: Neurological Research - December 25, 2023 Category: Neurology Authors: Sadegh Izadi Maryam Abdolrezaei Roksana Soukhaklari Maryam Moosavi Source Type: research
Enriched environment enhanced the astrocyte-derived BDNF and VEGF expression and alleviate white matter injuries of rats with ischemic stroke
CONCLUSION: These data suggest that the enriched environment contributes to brain white matter recovery and improvement of cognitive function after stroke. The mechanism is related to astrocytes and their secretions. EE can activate astrocytes to secrete BDNF and VEGF, which may be crucial to promote white matter recovery.PMID:38145566 | DOI:10.1080/01616412.2023.2298136 (Source: Neurological Research)
Source: Neurological Research - December 25, 2023 Category: Neurology Authors: Yi-Sha Guo Xia Bi Source Type: research
Memory impairment induced by aluminum nanoparticles is associated with hippocampal IL-1 and IBA-1 upregulation in mice
DISCUSSION: These findings indicate that the memory impairing effect of Al-NP coincides with hippocampal inflammation. According to the proposed relationship between AD and Al toxicity, this study can increase the knowledge about the toxic effects of Al-NP and highlight the need to limit the use of this nanoparticle.PMID:38145565 | DOI:10.1080/01616412.2023.2298137 (Source: Neurological Research)
Source: Neurological Research - December 25, 2023 Category: Neurology Authors: Sadegh Izadi Maryam Abdolrezaei Roksana Soukhaklari Maryam Moosavi Source Type: research
