Evaluation of the relationship between serum BDNF concentration and indicators of oxidative stress and inflammation in COVID-19 patients with neurological disorders - a pilot study
CONCLUSION: Using over-the-counter (OTC) medicines which include thiol-group-related agents or any other antioxidants can alleviate oxidative stress and the associated increased inflammation in COVID-19 patients with neurological symptoms.PMID:37706246 | DOI:10.1080/01616412.2023.2257448 (Source: Neurological Research)
Source: Neurological Research - September 14, 2023 Category: Neurology Authors: Kowsar Bavarsad Davood Shalil Ahmadi Mohammad Momeni Mohammad Jafar Yadyad Roya Salehi Kahyesh Hamid Moradzadegan Samireh Ghafouri Source Type: research
Pharmacogenetic study of phosphatase and tensin homolog polymorphism (rs701848) in childhood epilepsy: relation to circulating Wnt signaling
CONCLUSION: We originally found a strong association between PTEN rs701848 T/C and childhood epilepsy, in particular pharmacoresistant type. Serum Wnt3a levels increased in epilepsy, but were not significantly different between different alleles of PTEN. In pharmaco-responsive children Wnt3a levels differed significantly between the different PTEN genotypes. Antiepileptics may affect Wnt3a levels.PMID:37706249 | DOI:10.1080/01616412.2023.2257465 (Source: Neurological Research)
Source: Neurological Research - September 14, 2023 Category: Neurology Authors: Mohammed H Hassan Ahmed Y Nassar Abdel-Raheim M A Meki Shimaa A Nasser Ali Helmi Bakri Eman Radwan Source Type: research
Evaluation of the relationship between serum BDNF concentration and indicators of oxidative stress and inflammation in COVID-19 patients with neurological disorders - a pilot study
CONCLUSION: Using over-the-counter (OTC) medicines which include thiol-group-related agents or any other antioxidants can alleviate oxidative stress and the associated increased inflammation in COVID-19 patients with neurological symptoms.PMID:37706246 | DOI:10.1080/01616412.2023.2257448 (Source: Neurological Research)
Source: Neurological Research - September 14, 2023 Category: Neurology Authors: Kowsar Bavarsad Davood Shalil Ahmadi Mohammad Momeni Mohammad Jafar Yadyad Roya Salehi Kahyesh Hamid Moradzadegan Samireh Ghafouri Source Type: research
Pharmacogenetic study of phosphatase and tensin homolog polymorphism (rs701848) in childhood epilepsy: relation to circulating Wnt signaling
CONCLUSION: We originally found a strong association between PTEN rs701848 T/C and childhood epilepsy, in particular pharmacoresistant type. Serum Wnt3a levels increased in epilepsy, but were not significantly different between different alleles of PTEN. In pharmaco-responsive children Wnt3a levels differed significantly between the different PTEN genotypes. Antiepileptics may affect Wnt3a levels.PMID:37706249 | DOI:10.1080/01616412.2023.2257465 (Source: Neurological Research)
Source: Neurological Research - September 14, 2023 Category: Neurology Authors: Mohammed H Hassan Ahmed Y Nassar Abdel-Raheim M A Meki Shimaa A Nasser Ali Helmi Bakri Eman Radwan Source Type: research
miR-148b-3p suppresses the proliferation and migration of Schwann cells by targeting USP6 following sciatic nerve injury
CONCLUSION: Our data demonstrated the functional role of miR-148b-3p/USP6 axis in regulating the migration and proliferation of Schwann cells following peripheral nerve injury. miR-148b-3p showed downregulation and its target USP6 was upregulated after nerve transection procedure. Targeting miR-148b-3p/USP6 axis may provide a novel opportunity for peripheral nerve repair.PMID:37702221 | DOI:10.1080/01616412.2023.2257413 (Source: Neurological Research)
Source: Neurological Research - September 13, 2023 Category: Neurology Authors: Qin Zhang Chengkun Guo Lijuan Liu Yang Li Source Type: research
Autocrine motility factor receptor promotes the malignancy of glioblastoma by regulating cell migration and invasion
CONCLUSION: This study suggests that AMFR could be used as a therapeutic strategy for the clinical treatment of glioblastoma.PMID:37703903 | DOI:10.1080/01616412.2023.2257463 (Source: Neurological Research)
Source: Neurological Research - September 13, 2023 Category: Neurology Authors: Yao Zhang Xiuping Wang Guanghui Chen Yajing Lu Qiang Chen Source Type: research
miR-148b-3p suppresses the proliferation and migration of Schwann cells by targeting USP6 following sciatic nerve injury
CONCLUSION: Our data demonstrated the functional role of miR-148b-3p/USP6 axis in regulating the migration and proliferation of Schwann cells following peripheral nerve injury. miR-148b-3p showed downregulation and its target USP6 was upregulated after nerve transection procedure. Targeting miR-148b-3p/USP6 axis may provide a novel opportunity for peripheral nerve repair.PMID:37702221 | DOI:10.1080/01616412.2023.2257413 (Source: Neurological Research)
Source: Neurological Research - September 13, 2023 Category: Neurology Authors: Qin Zhang Chengkun Guo Lijuan Liu Yang Li Source Type: research
Consequences of adolescent social isolation on behavior and synaptic plasticity in the dorsal and ventral hippocampus in male Wistar rats
CONCLUSIONS: Our findings suggest that adolescent social isolation has distinct effects on synaptic plasticity in the VH and DH and leads to emotional dysregulation rather than impairments in cognitive performance.PMID:37698124 | DOI:10.1080/01616412.2023.2257444 (Source: Neurological Research)
Source: Neurological Research - September 12, 2023 Category: Neurology Authors: Oksana Nikolaienko Mariia Klymenko Elena Isaeva Source Type: research
Effects of fluoride on oxidative DNA damage, nitric oxide level, lipid peroxidation and cholinesterase enzyme activity in a rotenone-induced experimental Parkinson's model
CONCLUSIONS: Findings suggest that NaF and ROT may interact synergistically leading to oxidative damage and neuronal cell loss. As a result, we believe that exposure to pesticides in combination with NaF is one of the environmental factors that should not be ignored in the etiology of neurological diseases such as PD in populations in areas with endemic fluorosis.PMID:37699078 | DOI:10.1080/01616412.2023.2257452 (Source: Neurological Research)
Source: Neurological Research - September 12, 2023 Category: Neurology Authors: Yilmaz Kocak Gokhan Oto Zubeyir Huyut Hamit Hakan Alp Fikret Turkan Ezgi Onay Source Type: research
The incidence of deep venous thrombosis in Parkinson's disease
CONCLUSION: Attention should be paid to the development of DVT in elderly patients with advanced stages of PD, progression in the H-Y stage, use of assistive devices, and progression in dyspnea scoring. There is also a need for studies on the benefit of DVT prophylaxis in PD patients with a high risk of venous thromboembolism.PMID:37699515 | DOI:10.1080/01616412.2023.2257441 (Source: Neurological Research)
Source: Neurological Research - September 12, 2023 Category: Neurology Authors: Emine Afsin Zeliha Co şgun Ramazan Kurul Şule Aydın Türkoğlu Source Type: research
The influence of symptom severity and fatigue on sleep quality in patients with myasthenia gravis
CONCLUSION: The study determined that the participants had clinically significant symptom severity in daily living, severe fatigue, and poor sleep quality. The participants with clinically significant severe symptoms in daily living and fatigue had higher sleep disturbances, daytime dysfunction, and poor sleep quality.PMID:37700391 | DOI:10.1080/01616412.2023.2257449 (Source: Neurological Research)
Source: Neurological Research - September 12, 2023 Category: Neurology Authors: P ınar Yeşil Demirci Zehra Eskimez Saliha Bozdo ğan Yeşilot Source Type: research
High prognostic nutritional index could be associated with improved survival in patients with brain metastases: a retrospective observational study
CONCLUSION: Our results suggest that PNI could be associated with survival in patients with brain metastases. Patients with a lower PNI had a significantly worse outcome in comparison with those with a higher PNI. Evaluation of PNI may provide additional prognostic information in patients with brain metastases.PMID:37700395 | DOI:10.1080/01616412.2023.2257438 (Source: Neurological Research)
Source: Neurological Research - September 12, 2023 Category: Neurology Authors: Ehsan Alimohammadi Michael T Lawton Seyed Reza Bagheri Elham Siahkamari Hajir Mehrbani Amirhossein Tondro Akram Amiri Parivash Kakavand Source Type: research
5-lipoxygenase as a target to sensitize glioblastoma to temozolomide treatment via β-catenin-dependent pathway
This study demonstrates that Alox5 is overexpressed in GBM but not normal neuronal tissues. Alox5 depletion inhibits the growth of GBM cells, both in bulky and stem-like populations, and enhances the anti-cancer effects of temozolomide. The mechanism behind this involves a decrease in β-catenin level and activity upon Alox5 depletion. The inhibitory effects of Alox5 can be reversed by the addition of a Wnt agonist. Additionally, the study reveals that zileuton, an Alox5 inhibitor approved for asthma treatment, significantly improves the efficacy of temozolomide in mice without causing toxicity. Combination index analysis ...
Source: Neurological Research - September 11, 2023 Category: Neurology Authors: Dong Tang Yue Hu Wenhong Gao Source Type: research
Bidirectional association between hypothyroidism and myasthenia gravis: a Mendelian randomized study
DISCUSSION: This MR study showed that hypothyroidism can increase the risk of MG. Further investigation into the underlying mechanisms of this potential causality is warranted to offer novel therapeutic options for MG in the future.PMID:37695759 | DOI:10.1080/01616412.2023.2257458 (Source: Neurological Research)
Source: Neurological Research - September 11, 2023 Category: Neurology Authors: Yiwen Bao Lufeng Wang Can Cui Fei Yu Jie Yang Dongya Huang Source Type: research
