APOBEC3C is a novel target for the immune treatment of lower-grade gliomas
CONCLUSIONS: A3C is an immune-related prognostic biomarker in LGGs. Developing drugs to block A3C could enhance the efficiency of immunotherapy and improve disease survival.Abbreviation: A3C: Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) type 3C; LGGs: lower-grade gliomas; CGGA: Chinese Glioma Genome Atlas; WGCNA: Weighted gene co-expression network analysis; scRNA: Single-cell RNA; HGG: higher-grade glioma; OS: overall survival; TME: tumor microenvironment; KM: Kaplan-Meier; PFI: progression-free interval; IDH: isocitrate dehydrogenase; ROC: receiver operating characteristic; GS: gene significance; MM:...
Source: Neurological Research - November 26, 2023 Category: Neurology Authors: Shufa Zhao Yuntao Li Jie Xu Liang Shen Source Type: research
Protective effect of melatonin on blood-brain barrier damage caused by Endotoxemia
CONCLUSIONS: MEL recovered the degenerative damage of sepsis by contributing to blood-brain barrier integrity, and by decreasing inflammation, thus the neuroprotective effects of MEL might provide an experimental basis for clinical applications.PMID:37989260 | DOI:10.1080/01616412.2023.2265244 (Source: Neurological Research)
Source: Neurological Research - November 21, 2023 Category: Neurology Authors: Kubra Tugce Kalkan Mukaddes Esrefoglu Sule Terzioglu-Usak Arzu Yay Source Type: research
