GSK4716 enhances 5-HT1AR expression by glucocorticoid receptor signaling in hippocampal HT22 cells
CONCLUSION: The results could provide insight into the potential applications of small molecules, such as GSK4716, in the regulation of 5-HT1AR expression, which plays a role in serotonergic neurotransmission.PMID:38555524 | DOI:10.1080/01616412.2024.2322180 (Source: Neurological Research)
Source: Neurological Research - March 31, 2024 Category: Neurology Authors: Juhee Lim Jiyeon Park Wonwoong Lee Hyun Jin Choi Source Type: research
Which one predicts mortality better in acute ischemic stroke: negative vs positive acute-phase reactants
CONCLUSION: According to the study data, albumin and TF levels, which are negative acute-phase reactants, are independent determinants of in-hospital mortality in patients with acute ischemic stroke in the emergency department.PMID:38555525 | DOI:10.1080/01616412.2024.2337513 (Source: Neurological Research)
Source: Neurological Research - March 31, 2024 Category: Neurology Authors: Ahmet Naci Koca Selen Acehan Salim Satar Muge Gulen Sarper Sevdimbas Mehmet Gorur İlker Ozturk Source Type: research
Artificial intelligence performance in clinical neurology queries: the ChatGPT model
CONCLUSION: ChatGPT had a moderate overall performance in clinical neurology and demonstrated inadequate performance in answering questions that required interpretation and critical thinking. It also displayed limited performance in specific subspecialties. It is essential to acknowledge the limitations of artificial intelligence and diligently verify medical information produced by such models using reliable sources.PMID:38522424 | DOI:10.1080/01616412.2024.2334118 (Source: Neurological Research)
Source: Neurological Research - March 24, 2024 Category: Neurology Authors: Erman Altunisik Yasemin Ekmekyapar Firat Emine Kilicparlar Cengiz Gulsum Bayana Comruk Source Type: research
Confounding factors impacting the Glasgow coma score: a literature review
CONCLUSIONS: An up-to-date comprehensive list of confounding factors has been created that may be used to aide in GCS recording in hopes of improving its accuracy and utility.PMID:38497232 | DOI:10.1080/01616412.2024.2329860 (Source: Neurological Research)
Source: Neurological Research - March 18, 2024 Category: Neurology Authors: Kaveh Barami Source Type: research
< em > N < /em > -acetylcysteine increases dopamine release and prevents the deleterious effects of 6-OHDA on the expression of VMAT2, α-synuclein, and tyrosine hydroxylase
CONCLUSIONS: Our findings contribute to the validation of compounds capable to restore dopamine homeostasis and shed light on the metabolic pathways that could be targeted to normalize dopamine turnover. Furthermore, our results highlight the effectiveness of the antioxidant NAC in the prevention of dopaminergic neurodegeneration in the present model.ABBREVIATIONS: DAT, dopamine transporter; 6-OHDA, 6-hydroxydopamine; NAC, N-acetylcysteine; PARP, poly (ADP-ribose) polymerase; RA; retinoic acid; ROS, reactive oxygen species; TH, tyrosine hydroxylase; TPA, 12-O-tetradecanoyl-phorbol-13-acetate; VMAT2, vesicle monoamine trans...
Source: Neurological Research - March 18, 2024 Category: Neurology Authors: Roine El-Habta Sara Af Bjerk én Ana Virel Source Type: research
Confounding factors impacting the Glasgow coma score: a literature review
CONCLUSIONS: An up-to-date comprehensive list of confounding factors has been created that may be used to aide in GCS recording in hopes of improving its accuracy and utility.PMID:38497232 | DOI:10.1080/01616412.2024.2329860 (Source: Neurological Research)
Source: Neurological Research - March 18, 2024 Category: Neurology Authors: Kaveh Barami Source Type: research
< em > N < /em > -acetylcysteine increases dopamine release and prevents the deleterious effects of 6-OHDA on the expression of VMAT2, α-synuclein, and tyrosine hydroxylase
CONCLUSIONS: Our findings contribute to the validation of compounds capable to restore dopamine homeostasis and shed light on the metabolic pathways that could be targeted to normalize dopamine turnover. Furthermore, our results highlight the effectiveness of the antioxidant NAC in the prevention of dopaminergic neurodegeneration in the present model.ABBREVIATIONS: DAT, dopamine transporter; 6-OHDA, 6-hydroxydopamine; NAC, N-acetylcysteine; PARP, poly (ADP-ribose) polymerase; RA; retinoic acid; ROS, reactive oxygen species; TH, tyrosine hydroxylase; TPA, 12-O-tetradecanoyl-phorbol-13-acetate; VMAT2, vesicle monoamine trans...
Source: Neurological Research - March 18, 2024 Category: Neurology Authors: Roine El-Habta Sara Af Bjerk én Ana Virel Source Type: research
Confounding factors impacting the Glasgow coma score: a literature review
CONCLUSIONS: An up-to-date comprehensive list of confounding factors has been created that may be used to aide in GCS recording in hopes of improving its accuracy and utility.PMID:38497232 | DOI:10.1080/01616412.2024.2329860 (Source: Neurological Research)
Source: Neurological Research - March 18, 2024 Category: Neurology Authors: Kaveh Barami Source Type: research
< em > N < /em > -acetylcysteine increases dopamine release and prevents the deleterious effects of 6-OHDA on the expression of VMAT2, α-synuclein, and tyrosine hydroxylase
CONCLUSIONS: Our findings contribute to the validation of compounds capable to restore dopamine homeostasis and shed light on the metabolic pathways that could be targeted to normalize dopamine turnover. Furthermore, our results highlight the effectiveness of the antioxidant NAC in the prevention of dopaminergic neurodegeneration in the present model.ABBREVIATIONS: DAT, dopamine transporter; 6-OHDA, 6-hydroxydopamine; NAC, N-acetylcysteine; PARP, poly (ADP-ribose) polymerase; RA; retinoic acid; ROS, reactive oxygen species; TH, tyrosine hydroxylase; TPA, 12-O-tetradecanoyl-phorbol-13-acetate; VMAT2, vesicle monoamine trans...
Source: Neurological Research - March 18, 2024 Category: Neurology Authors: Roine El-Habta Sara Af Bjerk én Ana Virel Source Type: research
Confounding factors impacting the Glasgow coma score: a literature review
CONCLUSIONS: An up-to-date comprehensive list of confounding factors has been created that may be used to aide in GCS recording in hopes of improving its accuracy and utility.PMID:38497232 | DOI:10.1080/01616412.2024.2329860 (Source: Neurological Research)
Source: Neurological Research - March 18, 2024 Category: Neurology Authors: Kaveh Barami Source Type: research
