No excess cancer risk for non-erosive disease
Nature Reviews Gastroenterology & Hepatology, Published online: 20 October 2023; doi:10.1038/s41575-023-00858-0No excess cancer risk for non-erosive disease (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - October 20, 2023 Category: Gastroenterology Authors: Caroline Barranco Source Type: research

C. difficile toxin strikes a nerve in the gut
Nature Reviews Gastroenterology & Hepatology, Published online: 10 October 2023; doi:10.1038/s41575-023-00855-3C. difficile toxin strikes a nerve in the gut (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - October 10, 2023 Category: Gastroenterology Authors: Katrina Ray Source Type: research

HDCA ameliorates NAFLD in mice
Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2023; doi:10.1038/s41575-023-00853-5HDCA ameliorates NAFLD in mice (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - October 6, 2023 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

Therapeutic developments in pancreatic cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 05 October 2023; doi:10.1038/s41575-023-00840-wThe incidence of pancreatic ductal adenocarcinoma (PDAC) is rising. In this Review, Hu and O’Reilly summarize the latest advances and clinical trials for the treatment of PDAC, including biomarkers, targeted therapies and immunotherapy as well as novel clinical trial designs. They also discuss emerging therapeutic options for this disease. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - October 5, 2023 Category: Gastroenterology Authors: Z. Ian Hu Eileen M. O ’Reilly Source Type: research

Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease
Nature Reviews Gastroenterology & Hepatology, Published online: 05 October 2023; doi:10.1038/s41575-023-00846-4Cirrhosis recompensation is gradually gaining traction, but a definition for recompensation in nonalcoholic fatty liver disease (NAFLD)-related cirrhosis is currently lacking. This Perspective provides an overview of the natural history of NAFLD and discusses NAFLD-related cirrhosis recompensation. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - October 5, 2023 Category: Gastroenterology Authors: Gong Feng Luca Valenti Vincent Wai-Sun Wong Yasser Mahrous Fouad Yusuf Yilmaz Won Kim Giada Sebastiani Zobair M. Younossi Virginia Hernandez-Gea Ming-Hua Zheng Source Type: research

Reduction in colorectal cancer incidence by screening endoscopy
Nature Reviews Gastroenterology & Hepatology, Published online: 04 October 2023; doi:10.1038/s41575-023-00847-3This Perspective explores the relationship between screening endoscopy and colorectal cancer incidence, examining available evidence and offering insights into the discrepancies between real-world and trial evidence alongside potential pitfalls with interpreting the data. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - October 4, 2023 Category: Gastroenterology Authors: Hermann Brenner Thomas Heisser Rafael Cardoso Michael Hoffmeister Source Type: research

Precision medicine in monogenic inflammatory bowel disease: proposed mIBD REPORT standards
Nature Reviews Gastroenterology & Hepatology, Published online: 03 October 2023; doi:10.1038/s41575-023-00838-4In this Expert Recommendation, Uhlig and colleagues review the therapeutic landscape for monogenic inflammatory bowel disease and propose recommendations for standardized reporting of clinical outcomes. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - October 3, 2023 Category: Gastroenterology Authors: Holm H. Uhlig Claire Booth Judy Cho Marla Dubinsky Anne M. Griffiths Bodo Grimbacher Sophie Hambleton Ying Huang Kelsey Jones Jochen Kammermeier Hirokazu Kanegane Sibylle Koletzko Daniel Kotlarz Christoph Klein Michael J. Lenardo Bernice Lo Dermot P. B. M Source Type: research

Understanding remodelling of bile ducts to promote polycystic liver disease
Nature Reviews Gastroenterology & Hepatology, Published online: 03 October 2023; doi:10.1038/s41575-023-00852-6Understanding remodelling of bile ducts to promote polycystic liver disease (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - October 3, 2023 Category: Gastroenterology Authors: Katrina Ray Source Type: research

Digital pathology for nonalcoholic steatohepatitis assessment
Nature Reviews Gastroenterology & Hepatology, Published online: 03 October 2023; doi:10.1038/s41575-023-00843-7Histological assessment of nonalcoholic fatty liver disease (NAFLD) is essential for clinical practice as it outlines diagnosis and lays the foundation of medical care. This Perspective summarizes the advancements in digital histology and discusses current and future applications in NAFLD. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - October 3, 2023 Category: Gastroenterology Authors: Arun J. Sanyal Prakash Jha David E. Kleiner Source Type: research

Gut syndromes and Parkinson disease prediction
Nature Reviews Gastroenterology & Hepatology, Published online: 27 September 2023; doi:10.1038/s41575-023-00851-7Gut syndromes and Parkinson disease prediction (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 27, 2023 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Human liver tissue in a mouse host
Nature Reviews Gastroenterology & Hepatology, Published online: 27 September 2023; doi:10.1038/s41575-023-00849-1Human liver tissue in a mouse host (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 27, 2023 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Long-term normothermic liver perfusion
Nature Reviews Gastroenterology & Hepatology, Published online: 27 September 2023; doi:10.1038/s41575-023-00850-8Long-term normothermic liver perfusion (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 27, 2023 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Risk score for liver-related outcomes
Nature Reviews Gastroenterology & Hepatology, Published online: 27 September 2023; doi:10.1038/s41575-023-00848-2Risk score for liver-related outcomes (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 27, 2023 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Turning our focus to liver fibrosis
Nature Reviews Gastroenterology & Hepatology, Published online: 26 September 2023; doi:10.1038/s41575-023-00844-6Liver fibrosis is a substantial risk factor for liver cancer development. In this issue, we focus on molecular and cellular mechanisms of hepatic fibrogenesis and discuss therapeutic implications. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 26, 2023 Category: Gastroenterology Source Type: research

Changing epidemiology of colorectal cancer — birth cohort effects and emerging risk factors
Nature Reviews Gastroenterology & Hepatology, Published online: 18 September 2023; doi:10.1038/s41575-023-00841-9In this Review, Murphy and Zaki discuss changes in the incidence and mortality of colorectal cancer, including trends by age and birth cohort, and consider the contributions of early-life exposures and emerging risk factors. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 18, 2023 Category: Gastroenterology Authors: Caitlin C. Murphy Timothy A. Zaki Source Type: research