Guidelines for best practices in monitoring established coeliac disease in adult patients
Nature Reviews Gastroenterology & Hepatology, Published online: 18 December 2023; doi:10.1038/s41575-023-00872-2Coeliac disease is a chronic inflammatory disease triggered by gluten consumption in individuals with a genetic susceptibility. These Evidence-Based Guidelines provide recommendations for improving the health care of the patients and discuss future perspectives. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 18, 2023 Category: Gastroenterology Authors: Luca Elli Daniel Leffler Christophe Cellier Benjamin Lebwohl Carolina Ciacci Michael Schumann Knut E. A. Lundin Stefania Chetcuti Zammit Reena Sidhu Leda Roncoroni Julio C. Bai Anne R. Lee Melinda Dennis Marie E. Robert Kamran Rostami Sherine Khater Isabe Source Type: research

Neutrophils: from IBD to the gut microbiota
Nature Reviews Gastroenterology & Hepatology, Published online: 18 December 2023; doi:10.1038/s41575-023-00871-3In this Review, Danne and colleagues describe the roles of neutrophils in inflammatory bowel disease, as well as their functions in host–microbiota interactions. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 18, 2023 Category: Gastroenterology Authors: Camille Danne Jurate Skerniskyte Benoit Marteyn Harry Sokol Source Type: research

The maternal gut microbiome in pregnancy: implications for the developing immune system
Nature Reviews Gastroenterology & Hepatology, Published online: 14 December 2023; doi:10.1038/s41575-023-00864-2This Review discusses how the maternal gut microbiome in pregnancy influences the developing immune system and proposes avenues for future research. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 14, 2023 Category: Gastroenterology Authors: Omry Koren Liza Konnikova Petter Brodin Indira U. Mysorekar Maria Carmen Collado Source Type: research

A new era in obesity management
Nature Reviews Gastroenterology & Hepatology, Published online: 13 December 2023; doi:10.1038/s41575-023-00887-92023 was the most memorable year on record for obesity. The American Academy of Pediatrics recognized the complex, multifactorial nature of obesity and the broad range of treatments necessary to care for pediatric patients. The first-ever triple agonist and high-potency oral GLP1 agonist was introduced with unprecedented results. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 13, 2023 Category: Gastroenterology Authors: Fatima Cody Stanford Source Type: research

Fermented foods and gastrointestinal health: underlying mechanisms
Nature Reviews Gastroenterology & Hepatology, Published online: 11 December 2023; doi:10.1038/s41575-023-00869-xFermented foods have gained renewed popularity owing to their health-promoting potential. This Review discusses the mechanisms underlying the benefits of fermented foods in gut health and disease, highlighting how specific fermented food microorganisms, food components and bioactive compounds exert their effects. A future outlook on research is also detailed. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 11, 2023 Category: Gastroenterology Authors: Arghya Mukherjee Samuel Breselge Eirini Dimidi Maria L. Marco Paul D. Cotter Source Type: research

Novel interventions against alcohol-related liver disease
Nature Reviews Gastroenterology & Hepatology, Published online: 11 December 2023; doi:10.1038/s41575-023-00877-xIn 2023, there were significant advancements in trials of interventions to reduce mortality and morbidity from alcohol-related liver disease, spanning the entire spectrum of disease: primary prevention to reduce overall alcohol-related harm, secondary prevention to attenuate fibrosis progression and tertiary prevention using antibiotics for severe alcohol-associated hepatitis. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 11, 2023 Category: Gastroenterology Authors: Maja Thiele Christophe Moreno Source Type: research

Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Nature Reviews Gastroenterology & Hepatology, Published online: 08 December 2023; doi:10.1038/s41575-023-00867-zGut microbiota has a vital role in mechanisms involved in overweight and obesity, including host metabolism and energy expenditure. This Review describes the physiology of white and brown adipose tissue and provides timely insights into the gut microbiota–adipose tissue axis. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 8, 2023 Category: Gastroenterology Authors: Patrice D. Cani Matthias Van Hul Source Type: research

New options for late-line treatment of metastatic colorectal cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 08 December 2023; doi:10.1038/s41575-023-00881-1Metastatic colorectal cancer is a heterogeneous disease associated with poor patient outcomes. Although the past decade has seen few first-line treatment advances, key studies published in 2023 established new options for late-line therapy of the disease with and without oncogenic drivers, thus expanding the continuum of care in metastatic colorectal cancer. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 8, 2023 Category: Gastroenterology Authors: Sara Lonardi Filippo Pietrantonio Source Type: research

RET signalling controls gut motility
Nature Reviews Gastroenterology & Hepatology, Published online: 08 December 2023; doi:10.1038/s41575-023-00882-0RET signalling controls gut motility (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 8, 2023 Category: Gastroenterology Authors: Katrina Ray Source Type: research

Upgrading therapeutic ambitions and treatment outcomes
Nature Reviews Gastroenterology & Hepatology, Published online: 07 December 2023; doi:10.1038/s41575-023-00885-xImportant studies published in 2023 outlined new agents and strategies for the management of inflammatory bowel disease. Therapeutic ambitions for the management of inflammatory bowel disease were raised by the success of combinations of biologic agents in ulcerative colitis and early surgical resection in Crohn’s disease. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 7, 2023 Category: Gastroenterology Authors: Paulo Gustavo Kotze Severine Vermeire Source Type: research

Tumour-associated macrophages and pancreatic cancer: an inflammatory loop
Nature Reviews Gastroenterology & Hepatology, Published online: 07 December 2023; doi:10.1038/s41575-023-00886-wTumour-associated macrophages and pancreatic cancer: an inflammatory loop (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 7, 2023 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

Role of steatotic liver disease in prediction and prevention of cardiometabolic diseases
Nature Reviews Gastroenterology & Hepatology, Published online: 06 December 2023; doi:10.1038/s41575-023-00880-2Steatotic liver disease has emerged as an important risk factor for cardiovascular disease, type 2 diabetes mellitus and chronic kidney disease. Successful treatment of steatotic liver disease might also be effective in preventing these cardiometabolic diseases. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 6, 2023 Category: Gastroenterology Authors: Norbert Stefan Amedeo Lonardo Giovanni Targher Source Type: research

Microbiota-based biomarkers and therapeutics for cancer management
Nature Reviews Gastroenterology & Hepatology, Published online: 06 December 2023; doi:10.1038/s41575-023-00879-9New light is being shed on the interactions between the gut microbiome, cancer cell signalling and the host immune response. With this knowledge, microbiota-based approaches for improving cancer prevention, prognostication and therapy have started to materialize and will contribute to reducing the global cancer burden. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 6, 2023 Category: Gastroenterology Authors: William K. K. Wu Jun Yu Source Type: research

Elafibranor in primary biliary cholangitis
Nature Reviews Gastroenterology & Hepatology, Published online: 30 November 2023; doi:10.1038/s41575-023-00878-wElafibranor in primary biliary cholangitis (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 30, 2023 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 30 November 2023; doi:10.1038/s41575-023-00856-2In this Review, Besselink and colleagues discuss preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable pancreatic cancer and locally advanced pancreatic cancer, including disease staging and response evaluation. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 30, 2023 Category: Gastroenterology Authors: Thomas F. Stoop Rutger T. Theijse Leonard W. F. Seelen Bas Groot Koerkamp Casper H. J. van Eijck Christopher L. Wolfgang Geertjan van Tienhoven Hjalmar C. van Santvoort I. Quintus Molenaar Johanna W. Wilmink Marco Del Chiaro Matthew H. G. Katz Thilo Hacke Source Type: research