Digestive Disease Week 2023
Nature Reviews Gastroenterology & Hepatology, Published online: 06 July 2023; doi:10.1038/s41575-023-00819-7Digestive Disease Week 2023 (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 6, 2023 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

Lifestyle interventions in nonalcoholic fatty liver disease
Nature Reviews Gastroenterology & Hepatology, Published online: 04 July 2023; doi:10.1038/s41575-023-00800-4Nonalcoholic fatty liver disease (NALFD) prevalence, including in children and adolescents, is rising worldwide. This Review offers a comprehensive overview of the lifestyle interventions available for NAFLD, including dietary and physical-activity strategies. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 4, 2023 Category: Gastroenterology Authors: Zobair M. Younossi Shira Zelber-Sagi Linda Henry Lynn H. Gerber Source Type: research

Hepatic inflammatory responses in liver fibrosis
Nature Reviews Gastroenterology & Hepatology, Published online: 03 July 2023; doi:10.1038/s41575-023-00807-xLiver inflammation is a key process that orchestrates intrahepatic injury. This Review offers a comprehensive overview of the inflammatory mechanisms of hepatic fibrosis and discusses current advances and therapeutic implications. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 3, 2023 Category: Gastroenterology Authors: Linda Hammerich Frank Tacke Source Type: research

Author Correction: Etrasimod for ulcerative colitis: evaluating phase III results
Nature Reviews Gastroenterology & Hepatology, Published online: 03 July 2023; doi:10.1038/s41575-023-00817-9Author Correction: Etrasimod for ulcerative colitis: evaluating phase III results (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 3, 2023 Category: Gastroenterology Authors: Katsuyoshi Matsuoka Toshifumi Hibi Source Type: research

Cathepsin S in liver fibrogenesis
Nature Reviews Gastroenterology & Hepatology, Published online: 30 June 2023; doi:10.1038/s41575-023-00815-xCathepsin S in liver fibrogenesis (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 30, 2023 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Upadacitinib therapy for Crohn’s disease
Nature Reviews Gastroenterology & Hepatology, Published online: 27 June 2023; doi:10.1038/s41575-023-00812-0Upadacitinib therapy for Crohn’s disease (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 27, 2023 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Preoperative FOLFOX treatment in rectal cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 27 June 2023; doi:10.1038/s41575-023-00814-yPreoperative FOLFOX treatment in rectal cancer (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 27, 2023 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Liver dialysis in ACLF
Nature Reviews Gastroenterology & Hepatology, Published online: 27 June 2023; doi:10.1038/s41575-023-00811-1Liver dialysis in ACLF (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 27, 2023 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Phage therapy alleviates NAFLD in mice
Nature Reviews Gastroenterology & Hepatology, Published online: 27 June 2023; doi:10.1038/s41575-023-00810-2Phage therapy alleviates NAFLD in mice (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 27, 2023 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Advances in the management of acute pancreatitis
Nature Reviews Gastroenterology & Hepatology, Published online: 21 June 2023; doi:10.1038/s41575-023-00808-wRecent randomized controlled trials in acute pancreatitis have provided evidence that challenges current approaches to management, including fluid resuscitation, antibiotic administration, management of infected necrosis and use of early endoscopic retrograde cholangiopancreatography. The evidence means that we need to reassess the current management guidelines. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 21, 2023 Category: Gastroenterology Authors: Enrique de-Madaria James L. Buxbaum Source Type: research

Innovations to improve the efficiency of phase II IBD clinical trials
Nature Reviews Gastroenterology & Hepatology, Published online: 12 June 2023; doi:10.1038/s41575-023-00805-zInflammatory bowel disease (IBD) clinical trials face a recruitment crisis. This is attributable to multiple individual trials competing for the same pool of participants, growing sample size demands and the increased availability of licensed alternative options for many potential participants. We need phase II trials that are more efficient both in design and in outcomes measured in order to deliver earlier and more precise answers, rather than simply offering a crude preview of what a subsequent phase III trial...
Source: Nature Reviews Gastroenterology and Hepatology - June 12, 2023 Category: Gastroenterology Authors: Nurulamin M. Noor Tim Raine Source Type: research

Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology
Nature Reviews Gastroenterology & Hepatology, Published online: 08 June 2023; doi:10.1038/s41575-023-00792-1This Review discusses the role of the circadian clock in liver homeostasis, and how dysfunction of the liver circadian clock is associated with several liver-related diseases, including nonalcoholic fatty liver disease, type 2 diabetes mellitus and hepatocellular carcinoma. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 8, 2023 Category: Gastroenterology Authors: Nityanand Bolshette Hussam Ibrahim Hans Reinke Gad Asher Source Type: research

Measuring NAFLD models of care
Nature Reviews Gastroenterology & Hepatology, Published online: 08 June 2023; doi:10.1038/s41575-023-00798-9In this Comment, we provide a strategic framework for what could and should be measured, across four domains, to optimize standards of care for multidisciplinary models of care in nonalcoholic fatty liver disease. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 8, 2023 Category: Gastroenterology Authors: Alina M. Allen Zobair M. Younossi Emmanuel A. Tsochatzis William Alazawi Shira Zelber-Sagi Juan Pablo Arab Kenneth Cusi Jeffrey V. Lazarus Source Type: research

Epigenetic plasticity associated with pancreatic tumorigenesis in mice
Nature Reviews Gastroenterology & Hepatology, Published online: 07 June 2023; doi:10.1038/s41575-023-00806-yEpigenetic plasticity associated with pancreatic tumorigenesis in mice (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 7, 2023 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

The International Network on Oesophageal Atresia (INoEA) consensus guidelines on the transition of patients with oesophageal atresia–tracheoesophageal fistula
Nature Reviews Gastroenterology & Hepatology, Published online: 07 June 2023; doi:10.1038/s41575-023-00789-wCurrently, systematic care for adults and adolescents with oesophageal atresia–tracheoesophageal fistula (EA-TEF) as they transition into adulthood is lacking. A multidisciplinary group of experts structured this Consensus Statement offering guidelines for the care of adolescents and adults with EA-TEF during transition. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 7, 2023 Category: Gastroenterology Authors: Usha Krishnan Michael W. Dumont Hayley Slater Benjamin D. Gold David Seguy Mikael Bouin Rene Wijnen Luigi Dall ’Oglio Mario Costantini Anastassios C. Koumbourlis Thomas A. Kovesi Michael J. Rutter Marlene Soma Jessica Menzies Audrey Van Malleghem Nathal Source Type: research