NAFLD, MAFLD and obesity: brothers in arms?
Nature Reviews Gastroenterology & Hepatology, Published online: 05 December 2022; doi:10.1038/s41575-022-00717-42022 was a proficuous year in both the nonalcoholic fatty liver disease (NAFLD) and obesity fields. Pharmacological treatment for obesity and NAFLD is moving forward, with the possibility of replacing bariatric surgery, artificial intelligence might help us access the histological effects of new drugs, and there were advances in personalized hepatocellular carcinoma screening in patients with NAFLD. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - December 5, 2022 Category: Gastroenterology Authors: Mariana Verdelho Machado Helena Cortez-Pinto Source Type: research

The current paradigm of bariatric surgery in adolescents
Nature Reviews Gastroenterology & Hepatology, Published online: 29 November 2022; doi:10.1038/s41575-022-00713-8Severe obesity in adolescents affects their health and quality of life. Currently, metabolic and bariatric surgery (MBS) is the only effective intervention, but only a limited number of individuals undergo MBS procedures. Therefore, vigorous research in MBS is a priority for the benefit of adolescents with obesity. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 29, 2022 Category: Gastroenterology Authors: Thomas H. Inge Justin R. Ryder Source Type: research

Targeting the gut microenvironment in IBS to improve symptoms
Nature Reviews Gastroenterology & Hepatology, Published online: 29 November 2022; doi:10.1038/s41575-022-00718-3Key studies published in 2022 further established the importance of alterations in the gut microenvironment and interactions with the enteric and central nervous systems in symptom generation in irritable bowel syndrome and suggested novel and clinically accessible therapeutic approaches for this large group of patients. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 29, 2022 Category: Gastroenterology Authors: Magnus Simr én Source Type: research

Elucidating the genetic and epigenetic evolution and phenotypic plasticity of colorectal tumours
Nature Reviews Gastroenterology & Hepatology, Published online: 28 November 2022; doi:10.1038/s41575-022-00721-8Elucidating the genetic and epigenetic evolution and phenotypic plasticity of colorectal tumours (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 28, 2022 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

A novel pathomics signature for gastric cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 28 November 2022; doi:10.1038/s41575-022-00719-2A novel pathomics signature for gastric cancer (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 28, 2022 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

Testing regulatory T cells for liver transplantation tolerance
Nature Reviews Gastroenterology & Hepatology, Published online: 28 November 2022; doi:10.1038/s41575-022-00720-9Testing regulatory T cells for liver transplantation tolerance (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 28, 2022 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

Mechanosensitive release of 5-HT from specialized intestinal epithelial cells
Nature Reviews Gastroenterology & Hepatology, Published online: 23 November 2022; doi:10.1038/s41575-022-00712-9Mechanosensitive release of 5-HT from specialized intestinal epithelial cells (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 23, 2022 Category: Gastroenterology Authors: Constanza Alcaino Source Type: research

Targeting hyperactive tRNA modification improves anti-PD1 efficacy
Nature Reviews Gastroenterology & Hepatology, Published online: 23 November 2022; doi:10.1038/s41575-022-00715-6Targeting hyperactive tRNA modification improves anti-PD1 efficacy (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 23, 2022 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Evolving therapeutic landscape of advanced hepatocellular carcinoma
Nature Reviews Gastroenterology & Hepatology, Published online: 11 November 2022; doi:10.1038/s41575-022-00704-9This Review discusses the current and emerging therapeutic landscape for treatment of advanced hepatocellular carcinoma, including molecular-targeted monotherapies, immuno-oncology monotherapies, combination therapies and novel therapeutic approaches. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 11, 2022 Category: Gastroenterology Authors: Chen Yang Hailin Zhang Linmeng Zhang Andrew X. Zhu Ren é Bernards Wenxin Qin Cun Wang Source Type: research

The microbiota and the gut–liver axis in primary sclerosing cholangitis
Nature Reviews Gastroenterology & Hepatology, Published online: 09 November 2022; doi:10.1038/s41575-022-00690-yPrimary sclerosing cholangitis (PSC) is closely associated with inflammatory bowel disease (IBD) and potentially provides unique insights into the gut–liver axis. This Review explores these links and provides an overview of the gut microbiome in PSC, including PSC–IBD, exploring related hypotheses of disease mechanisms. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 9, 2022 Category: Gastroenterology Authors: Johannes R. Hov Tom H. Karlsen Source Type: research

Artificial intelligence and automation in endoscopy and surgery
Nature Reviews Gastroenterology & Hepatology, Published online: 09 November 2022; doi:10.1038/s41575-022-00701-yAdvances in artificial intelligence (AI) are changing endoscopy and gastrointestinal surgery, including computer-assisted detection and diagnosis, computer-aided navigation, robot-assisted intervention and automated reporting. This Perspective introduces the role of AI in computer-assisted interventions in gastroenterology with insights on regulatory aspects and the challenges ahead. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 9, 2022 Category: Gastroenterology Authors: Fran çois Chadebecq Laurence B. Lovat Danail Stoyanov Source Type: research

Current developments in gastric cancer: from molecular profiling to treatment strategy
Nature Reviews Gastroenterology & Hepatology, Published online: 07 November 2022; doi:10.1038/s41575-022-00703-wGastric and gastro-oesophageal cancer is a leading cause of cancer-related death worldwide with a poor prognosis. This Review provides a comprehensive overview of current treatment strategies set on a molecular basis, and discusses future therapeutic avenues. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 7, 2022 Category: Gastroenterology Authors: Maria Alsina Virginia Arrazubi Marc Diez Josep Tabernero Source Type: research

Integrated systems approach to identify environmental factors in intestinal inflammation
Nature Reviews Gastroenterology & Hepatology, Published online: 04 November 2022; doi:10.1038/s41575-022-00708-5Integrated systems approach to identify environmental factors in intestinal inflammation (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 4, 2022 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

Investigating two versus three doses of mRNA vaccine in patients with cirrhosis
Nature Reviews Gastroenterology & Hepatology, Published online: 04 November 2022; doi:10.1038/s41575-022-00711-wInvestigating two versus three doses of mRNA vaccine in patients with cirrhosis (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 4, 2022 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

Colonoscopy screening and risk of CRC
Nature Reviews Gastroenterology & Hepatology, Published online: 04 November 2022; doi:10.1038/s41575-022-00709-4Colonoscopy screening and risk of CRC (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 4, 2022 Category: Gastroenterology Authors: Jordan Hindson Source Type: research