Targeting the endocannabinoid system for the treatment of abdominal pain in irritable bowel syndrome
Nature Reviews Gastroenterology & Hepatology, Published online: 27 September 2022; doi:10.1038/s41575-022-00682-yThere are limited available treatment options for the management of abdominal pain in irritable bowel syndrome (IBS). This Review provides an overview of the gastrointestinal endocannabinoid system and its potential as a therapeutic target for the treatment of pain in IBS. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 27, 2022 Category: Gastroenterology Authors: Stuart M. Brierley Beverley Greenwood-Van Meerveld Giovanni Sarnelli Keith A. Sharkey Martin Storr Jan Tack Source Type: research

Human duodenal cells contribute to liver regeneration
Nature Reviews Gastroenterology & Hepatology, Published online: 27 September 2022; doi:10.1038/s41575-022-00696-6Human duodenal cells contribute to liver regeneration (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 27, 2022 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Gut–brain axis key to fat preference
Nature Reviews Gastroenterology & Hepatology, Published online: 27 September 2022; doi:10.1038/s41575-022-00693-9Gut–brain axis key to fat preference (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 27, 2022 Category: Gastroenterology Authors: Katrina Ray Source Type: research

Robotic surgery for middle and low rectal cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 27 September 2022; doi:10.1038/s41575-022-00695-7Robotic surgery for middle and low rectal cancer (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 27, 2022 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Medical therapy of paediatric inflammatory bowel disease
Nature Reviews Gastroenterology & Hepatology, Published online: 16 September 2022; doi:10.1038/s41575-022-00686-8Antibodies targeting tumour necrosis factor have substantially advanced the treatment of paediatric inflammatory bowel disease. Understanding pharmacokinetics and therapeutic drug monitoring has led to increased efficacy and durability of response. Primary non-response is more common in ulcerative colitis than in Crohn’s disease, highlighting the need for alternative biologic agents and oral small molecules. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 16, 2022 Category: Gastroenterology Authors: Luca Scarallo Anne M. Griffiths Source Type: research

The role of goblet cells and mucus in intestinal homeostasis
Nature Reviews Gastroenterology & Hepatology, Published online: 12 September 2022; doi:10.1038/s41575-022-00675-xMucus, produced by goblet cells, provides the intestinal tract with an additional layer of protection. This Review discusses the role of mucus and goblet cells in intestinal health and disease, and dissects the underlying regulatory mechanisms. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 12, 2022 Category: Gastroenterology Authors: Jenny K. Gustafsson Malin E. V. Johansson Source Type: research

Showing a sensitive side
Nature Reviews Gastroenterology & Hepatology, Published online: 08 September 2022; doi:10.1038/s41575-022-00684-wIn science as in life, the language we choose to use is of great importance and power. This is particularly true in discussion of medical conditions. More care is needed to sensitively discuss diseases and patient care. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 8, 2022 Category: Gastroenterology Source Type: research

From stem to stern: LGR5+ as a marker for intestinal crypts
Nature Reviews Gastroenterology & Hepatology, Published online: 06 September 2022; doi:10.1038/s41575-022-00683-xFrom stem to stern: LGR5+ as a marker for intestinal crypts (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 6, 2022 Category: Gastroenterology Authors: Ghada Mohamed Source Type: research

Tango of B cells with T cells in the making of secretory antibodies to gut bacteria
Nature Reviews Gastroenterology & Hepatology, Published online: 02 September 2022; doi:10.1038/s41575-022-00674-ySecretory antibodies regulate intestinal bacteria, but their specificity and dependence on T cells have been matters of debate. This Perspective argues that bacteria-reactive antibodies are highly specific and that their production is under the control of T cells. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 2, 2022 Category: Gastroenterology Authors: Ludvig M. Sollid Rasmus Iversen Source Type: research

Nerves in gastrointestinal cancer: from mechanism to modulations
Nature Reviews Gastroenterology & Hepatology, Published online: 02 September 2022; doi:10.1038/s41575-022-00669-9The influence of nerves on cancer is beginning to be understood. This Review discusses emerging insights into the role of the nervous system in gastrointestinal cancer and of nerves as components of the tumour microenvironment, highlighting underlying mechanisms and its potential as a therapeutic target. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 2, 2022 Category: Gastroenterology Authors: Nathalie Vaes Musa Idris Werend Boesmans Maria M. Alves Veerle Melotte Source Type: research

Methanogenic archaea in the human gastrointestinal tract
Nature Reviews Gastroenterology & Hepatology, Published online: 01 September 2022; doi:10.1038/s41575-022-00673-zArchaea are an overlooked member of the human gut microbiota. This Perspective discusses key characteristics of archaea, their role in human health and physiology, and the clinical relevance of methanogenic archaea in the human gastrointestinal tract. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 1, 2022 Category: Gastroenterology Authors: Christoph Hoegenauer Heinz F. Hammer Alexander Mahnert Christine Moissl-Eichinger Source Type: research

Bacterial histamine and abdominal pain in IBS
Nature Reviews Gastroenterology & Hepatology, Published online: 18 August 2022; doi:10.1038/s41575-022-00681-zBacterial histamine and abdominal pain in IBS (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 18, 2022 Category: Gastroenterology Authors: Katrina Ray Source Type: research

New insights into aetiology of paediatric liver cirrhosis
Nature Reviews Gastroenterology & Hepatology, Published online: 16 August 2022; doi:10.1038/s41575-022-00676-wNew insights into aetiology of paediatric liver cirrhosis (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 16, 2022 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

Phage therapy in IBD
Nature Reviews Gastroenterology & Hepatology, Published online: 15 August 2022; doi:10.1038/s41575-022-00677-9Phage therapy in IBD (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 15, 2022 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research

Hyperammonaemia in liver cirrhosis
Nature Reviews Gastroenterology & Hepatology, Published online: 15 August 2022; doi:10.1038/s41575-022-00679-7Hyperammonaemia in liver cirrhosis (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 15, 2022 Category: Gastroenterology Authors: Eleni Kotsiliti Source Type: research