Whole-cortex in situ sequencing reveals input-dependent area identity
Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07221-6BARseq interrogates the expression of 104 cell-type marker genes in 10.3 million cells over nine mouse forebrain hemispheres to reveal the role of peripheral inputs on cortical area development. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Xiaoyin Chen Stephan Fischer Mara C. P. Rue Aixin Zhang Didhiti Mukherjee Patrick O. Kanold Jesse Gillis Anthony M. Zador Source Type: research
A magnetar giant flare in the nearby starburst galaxy M82
We report observations of GRB 231115A, positionally coincident with the starburst galaxy M82, that unambiguously qualify this burst as a giant flare from a magnetar, which is a rare explosive event releasing gamma rays. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Sandro Mereghetti Michela Rigoselli Ruben Salvaterra Dominik Patryk Pacholski James Craig Rodi Diego Gotz Edoardo Arrigoni Paolo D ’Avanzo Christophe Adami Angela Bazzano Enrico Bozzo Riccardo Brivio Sergio Campana Enrico Cappellaro Jerome Chenevez Fior Source Type: research
Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07318-yVVD-133214, a clinical-stage, covalent allosteric inhibitor of the helicase WRN, was well tolerated in mice and led to robust tumour regression in multiple microsatellite-instability-high colorectal cancer cell lines and patient-derived xenograft models. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Kristen A. Baltgalvis Kelsey N. Lamb Kent T. Symons Chu-Chiao Wu Melissa A. Hoffman Aaron N. Snead Xiaodan Song Thomas Glaza Shota Kikuchi Jason C. Green Donald C. Rogness Betty Lam Maria E. Rodriguez-Aguirre David R. Woody Christie L. Eissler Socorro Rod Source Type: research
Single-cell analysis reveals context-dependent, cell-level selection of mtDNA
Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07332-0A new method for tracking single-cell heteroplasmy, called SCI-LITE, is combined with mitochondrial DNA base editing to reveal principles of heteroplasmy dynamics in dividing cells. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Anna V. Kotrys Timothy J. Durham Xiaoyan A. Guo Venkata R. Vantaku Sareh Parangi Vamsi K. Mootha Source Type: research
A high-density and high-confinement tokamak plasma regime for fusion energy
Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07313-3A stable tokamak plasma has been demonstrated with a high plasma density and a high energy confinement quality, both of which are simultaneously important for fusion reactors. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: S. Ding A. M. Garofalo H. Q. Wang D. B. Weisberg Z. Y. Li X. Jian D. Eldon B. S. Victor A. Marinoni Q. M. Hu I. S. Carvalho T. Odstr čil L. Wang A. W. Hyatt T. H. Osborne X. Z. Gong J. P. Qian J. Huang J. McClenaghan C. T. Holcomb J. M. Hanson Source Type: research
PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells
Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07254-xTumour-derived prostaglandin E2, signaling through its receptors EP2 and EP4, is shown to restrain the responses of tumour-infiltrating stem-like TCF1+CD8+ T lymphocytes, and modulation of T cell EP2 and EP4 can restore anticancer immunity. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Sebastian B. Lacher Janina D örr Gustavo P. de Almeida Julian H önninger Felix Bayerl Anna Hirschberger Anna-Marie Pedde Philippa Meiser Lukas Ramsauer Thomas J. Rudolph Nadine Spranger Matteo Morotti Alizee J. Grimm Sebastian Jarosch Arman Oner Lisa Gr Source Type: research
Growth of diamond in liquid metal at 1 atm pressure
Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07339-7Diamond crystals and polycrystalline diamond films can be grown using liquid metal at standard pressure and high temperature instead of conventional high pressure and high temperature. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Yan Gong Da Luo Myeonggi Choe Yongchul Kim Babu Ram Mohammad Zafari Won Kyung Seong Pavel Bakharev Meihui Wang In Kee Park Seulyi Lee Tae Joo Shin Zonghoon Lee Geunsik Lee Rodney S. Ruoff Source Type: research
Multi-project wafers for flexible thin-film electronics by independent foundries
Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07306-2The iconic 6502 microprocessor designed in two key thin-film transistor technologies by independent foundries is used to demonstrate and expand the multi-project wafer approach for flexible electronics. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Hikmet Çeliker Wim Dehaene Kris Myny Source Type: research
Antisense oligonucleotide therapeutic approach for Timothy syndrome
Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07310-6Antisense oligonucleotides effectively decrease the inclusion of exon 8A of CACNA1C in human cells both in vitro and in rodents transplanted with human brain organoids, and a single intrathecal administration rescued both calcium changes and in vivo dendrite morphology of patient neurons. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Xiaoyu Chen Fikri Birey Min-Yin Li Omer Revah Rebecca Levy Mayuri Vijay Thete Noah Reis Konstantin Kaganovsky Massimo Onesto Noriaki Sakai Zuzana Hudacova Jin Hao Xiangling Meng Seiji Nishino John Huguenard Sergiu P. Pa șca Source Type: research
Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers
Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07350-yHRO761 is a potent, selective, allosteric WRN inhibitor that binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Stephane Ferretti Jacques Hamon Ruben de Kanter Clemens Scheufler Rita Andraos-Rey Stephanie Barbe Elisabeth Bechter Jutta Blank Vincent Bordas Ernesta Dammassa Andrea Decker Noemi Di Nanni Marion Dourdoigne Elena Gavioli Marc Hattenberger Alisa Heuser Ch Source Type: research
High-performance fibre battery with polymer gel electrolyte
Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07343-xA fibre lithium-ion battery that can potentially be woven into textiles shows enhanced battery performance and safety compared with liquid electrolytes. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Chenhao Lu Haibo Jiang Xiangran Cheng Jiqing He Yao Long Yingfan Chang Xiaocheng Gong Kun Zhang Jiaxin Li Zhengfeng Zhu Jingxia Wu Jiajia Wang Yuanyuan Zheng Xiang Shi Lei Ye Meng Liao Xuemei Sun Bingjie Wang Peining Chen Yonggang Wang Huisheng Peng Source Type: research
This giant extinct salmon had tusks like a warthog
Nature, Published online: 24 April 2024; doi:10.1038/d41586-024-01146-wScientists initially thought that the outsized teeth were fangs, giving rise to the ‘sabre-toothed salmon’ nickname. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Source Type: research
Should the Maldives be creating new land?
Nature, Published online: 24 April 2024; doi:10.1038/d41586-024-01228-9The Maldives are racing to reclaim vast amounts of land to combat rising sea levels. But many are concerned that these efforts risk harming the paradise they aims to protect (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Shamini Bundell Jesse Chase-Lubitz Source Type: research
How gliding marsupials got their ‘wings’
Nature, Published online: 24 April 2024; doi:10.1038/d41586-024-01230-1Researchers find the genetic mutations that allow some marsupials to soar, and an ultra-accurate clock is put through its paces on the high seas. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Benjamin Thompson Elizabeth Gibney Source Type: research
Structures of human γδ T cell receptor–CD3 complex
Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07439-4Structures of human γδ T cell receptor–CD3 complex (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Weizhi Xin Bangdong Huang Ximin Chi Yuehua Liu Mengjiao Xu Yuanyuan Zhang Xu Li Qiang Su Qiang Zhou Source Type: research
