Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07318-yVVD-133214, a clinical-stage, covalent allosteric inhibitor of the helicase WRN, was well tolerated in mice and led to robust tumour regression in multiple microsatellite-instability-high colorectal cancer cell lines and patient-derived xenograft models.

Source: Nature AOP - April 24, 2024 Category: Research Authors: Kristen A. Baltgalvis Kelsey N. Lamb Kent T. Symons Chu-Chiao Wu Melissa A. Hoffman Aaron N. Snead Xiaodan Song Thomas Glaza Shota Kikuchi Jason C. Green Donald C. Rogness Betty Lam Maria E. Rodriguez-Aguirre David R. Woody Christie L. Eissler Socorro Rod Source Type: research