Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07350-yHRO761 is a potent, selective, allosteric WRN inhibitor that binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation.

Source: Nature AOP - April 24, 2024 Category: Research Authors: Stephane Ferretti Jacques Hamon Ruben de Kanter Clemens Scheufler Rita Andraos-Rey Stephanie Barbe Elisabeth Bechter Jutta Blank Vincent Bordas Ernesta Dammassa Andrea Decker Noemi Di Nanni Marion Dourdoigne Elena Gavioli Marc Hattenberger Alisa Heuser Ch Source Type: research