Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
Nature, Published online: 08 April 2024; doi:10.1038/s41586-024-07205-6RMC-7977, a compound that exhibits potent inhibition of the active states of mutant and wild-type KRAS, NRAS and HRAS variants has a strong anti-tumour effect on RAS-addicted tumours and is well tolerated in preclinical models. (Source: Nature AOP)
Source: Nature AOP - April 8, 2024 Category: Research Authors: Matthew Holderfield Bianca J. Lee Jingjing Jiang Aidan Tomlinson Kyle J. Seamon Alessia Mira Enrico Patrucco Grace Goodhart Julien Dilly Yevgeniy Gindin Nuntana Dinglasan Yingyun Wang Lick Pui Lai Shurui Cai Lingyan Jiang Nicole Nasholm Nataliya Shifrin C Source Type: research
Digging in: last chance to save a native forest
Nature, Published online: 08 April 2024; doi:10.1038/d41586-024-01004-9Dario Sandrini hikes, plants and digs to save a threatened and diminishing ecosystem. (Source: Nature AOP)
Source: Nature AOP - April 8, 2024 Category: Research Authors: James Mitchell Crow Source Type: research
The PARTNER trial of neoadjuvant olaparib in triple-negative breast cancer
Nature, Published online: 08 April 2024; doi:10.1038/s41586-024-07384-2The PARTNER trial of neoadjuvant olaparib in triple-negative breast cancer (Source: Nature AOP)
Source: Nature AOP - April 8, 2024 Category: Research Authors: Jean E. Abraham Karen Pinilla Alimu Dayimu Louise Grybowicz Nikolaos Demiris Caron Harvey Lynsey M. Drewett Rebecca Lucey Alexander Fulton Anne N. Roberts Joanna R. Worley Anita Chhabra Wendi Qian Anne-Laure Vallier Richard M. Hardy Steve Chan Tamas Hicki Source Type: research
Author Correction: Macromolecular condensation buffers intracellular water potential
Nature, Published online: 08 April 2024; doi:10.1038/s41586-024-07346-8Author Correction: Macromolecular condensation buffers intracellular water potential (Source: Nature AOP)
Source: Nature AOP - April 8, 2024 Category: Research Authors: Joseph L. Watson Estere Seinkmane Christine T. Styles Andrei Mihut Lara K. Kr üger Kerrie E. McNally Vicente Jose Planelles-Herrero Michal Dudek Patrick M. McCall Silvia Barbiero Michael Vanden Oever Sew Yeu Peak-Chew Benjamin T. Porebski Aiwei Zeng Nina Source Type: research
Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer
Nature, Published online: 08 April 2024; doi:10.1038/s41586-024-07379-zTumor-selective activity of RAS-GTP inhibition in pancreatic cancer (Source: Nature AOP)
Source: Nature AOP - April 8, 2024 Category: Research Authors: Urszula N. Wasko Jingjing Jiang Tanner C. Dalton Alvaro Curiel-Garcia A. Cole Edwards Yingyun Wang Bianca Lee Margo Orlen Sha Tian Clint A. Stalnecker Kristina Drizyte-Miller Marie Menard Julien Dilly Stephen A. Sastra Carmine F. Palermo Marie C. Hassellu Source Type: research
Survival of the nicest: have we got evolution the wrong way round?
Nature, Published online: 08 April 2024; doi:10.1038/d41586-024-00999-5How humans, animals and even single-celled organisms cooperate to survive suggests there’s more to life than just competition, argues a cheering study of evolutionary biology. (Source: Nature AOP)
Source: Nature AOP - April 8, 2024 Category: Research Authors: Jonathan R. Goodman Source Type: research
How to plug the female mentoring gap in Latin American science
Nature, Published online: 08 April 2024; doi:10.1038/d41586-024-01024-5Female academics who are keen to advance their careers need to see other women in leadership positions. Social stereotyping prevents that, argues Vanessa Gottifredi. (Source: Nature AOP)
Source: Nature AOP - April 8, 2024 Category: Research Authors: Julie Gould Source Type: research
Exclusive: official investigation reveals how superconductivity physicist faked blockbuster results
Nature, Published online: 06 April 2024; doi:10.1038/d41586-024-00976-yThe confidential 124-page report from the University of Rochester, disclosed in a lawsuit, details the extent of Ranga Dias’s scientific misconduct. (Source: Nature AOP)
Source: Nature AOP - April 6, 2024 Category: Research Authors: Dan Garisto Source Type: research
Sea spray carries huge amounts of ‘forever chemicals’ into the air
Nature, Published online: 05 April 2024; doi:10.1038/d41586-024-01030-7Long-lived compounds emitted by industry reach the oceans and are then ferried by bubbles into the atmosphere. (Source: Nature AOP)
Source: Nature AOP - April 5, 2024 Category: Research Source Type: research
Daily briefing: Diabetes drug shows promise against Parkinson’s
Nature, Published online: 05 April 2024; doi:10.1038/d41586-024-01049-wLixisenatide, a drug in the same family as Ozempic, seems to slow the progression of Parkinson’s disease. Plus, why scientists will look to the Sun’s corona during the 8 April eclipse. (Source: Nature AOP)
Source: Nature AOP - April 5, 2024 Category: Research Authors: Flora Graham Source Type: research
Baseball-sized hail in Spain began with a heatwave at sea
Nature, Published online: 05 April 2024; doi:10.1038/d41586-024-00966-0Climate change is partly to blame for a storm that pounded Girona province with record-breaking hailstones. (Source: Nature AOP)
Source: Nature AOP - April 5, 2024 Category: Research Source Type: research
After the genocide: what scientists are learning from Rwanda
Nature, Published online: 05 April 2024; doi:10.1038/d41586-024-00997-7Thirty years after the genocide against the Tutsi in Rwanda, Nature met with researchers who are gaining insights that could help to prevent other atrocities and enable healing. (Source: Nature AOP)
Source: Nature AOP - April 5, 2024 Category: Research Authors: Nisha Gaind Source Type: research
Long-lost photos reveal details of world’s first police crime lab
Nature, Published online: 05 April 2024; doi:10.1038/d41586-024-01005-8The archive, saved from a garage, shows pioneer of forensic science Edmond Locard at work in his laboratory in Lyon, France. (Source: Nature AOP)
Source: Nature AOP - April 5, 2024 Category: Research Authors: Laura Spinney Source Type: research
Audio long read: Why are so many young people getting cancer? What the data say
Nature, Published online: 05 April 2024; doi:10.1038/d41586-024-00884-1Researchers are scrambling to explain why rates of multiple cancers are increasing among adults under the age of 50. (Source: Nature AOP)
Source: Nature AOP - April 5, 2024 Category: Research Authors: Heidi Ledford Benjamin Thompson Source Type: research
Wild women and restoring public trust: Books in brief
Nature, Published online: 05 April 2024; doi:10.1038/d41586-024-01025-4Andrew Robinson reviews five of the best science picks. (Source: Nature AOP)
Source: Nature AOP - April 5, 2024 Category: Research Authors: Andrew Robinson Source Type: research
