Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

Nature, Published online: 08 April 2024; doi:10.1038/s41586-024-07205-6RMC-7977, a compound that exhibits potent inhibition of the active states of mutant and wild-type KRAS, NRAS and HRAS variants has a strong anti-tumour effect on RAS-addicted tumours and is well tolerated in preclinical models.

Source: Nature AOP - April 8, 2024 Category: Research Authors: Matthew Holderfield Bianca J. Lee Jingjing Jiang Aidan Tomlinson Kyle J. Seamon Alessia Mira Enrico Patrucco Grace Goodhart Julien Dilly Yevgeniy Gindin Nuntana Dinglasan Yingyun Wang Lick Pui Lai Shurui Cai Lingyan Jiang Nicole Nasholm Nataliya Shifrin C Source Type: research