Dobutamine Stress Cardiovascular Magnetic Resonance Derived 2-Dimension Feature Tracking Strain Analysis in Pediatric Population with Anomalous Aortic Origin of Right Coronary Artery
This study describes the utility of dobutamine stress cardiovascular magnetic resonance (DSCMR) and potential benefit of strain analysis in children with AAORCA. All patients less than 21 years of age with AAORCA who underwent DSCMR between July 2018 and December 2022 were included. Visual wall motion abnormalities (VWMA) at rest and during protocolized increments of dobutamine infusion were assessed. Regional and global left ventricular circumferential (GCS) and radial (GRS) strai n using 2-dimension Feature tracking (2D-FT) analysis (cvi42, Circle Cardiovascular Imaging Inc.) were calculated at rest and peak response. ...
Source: Mammalian Genome - January 17, 2024 Category: Genetics & Stem Cells Source Type: research
Utility of Balloon Occlusion Testing in Determining Fontan Suitability Among Patients with Elevated Pulmonary Artery Pressure and Additional Antegrade Pulmonary Blood Flow
AbstractIn individuals with a single ventricle undergoing evaluation before Fontan surgery, the presence of excessive pulmonary blood flow can contribute to increased pulmonary artery pressure, notably in those who had a Glenn procedure with antegrade pulmonary flow. 28 patients who had previously undergone Glenn anastomosis with antegrade pulmonary blood flow (APBF) and with elevated mean pulmonary artery (mPAP) pressure > 15 mmHg in diagnostic catheter angiography were included in the study. After addressing other anatomical factors that could affect pulmonary artery pressure, APBF was occluded with semi-compli...
Source: Mammalian Genome - January 5, 2024 Category: Genetics & Stem Cells Source Type: research
First Real-Life Data on the Diving Response in Healthy Children
This study was conducted to improve an understanding thereof. We used a stepwise apnea protocol with apnea at rest, apnea with facial immersion, and at last apnea during whole body submersion. Continuous measurement of heart rate, oxygen saturation, and peripheral resistance index was done. Physiologic data and analysis of influencing factors on heart rate, oxygen saturation, and peripheral vascular tone response are reported. The current study presents the first data of physiologic diving response in children. Data showed that facial or whole body submersion leads to a major drop in heart rate, and increase of peripheral ...
Source: Mammalian Genome - January 4, 2024 Category: Genetics & Stem Cells Source Type: research
Complimentary Cardiac Computed Tomography Ventricular Volumetry-Derived Metrics of Severity in Patients with Ebstein Anomaly: Comparison with Echocardiography-Based Severity Indices
AbstractDetailed three-dimensional cardiac segmentations using cardiac computed tomography (CT) data is technically feasible in patients with Ebstein anomaly, but its complementary role has not been evaluated. This single-center, retrospective study was aimed to evaluate the complementary role of cardiac CT ventricular volumetry in evaluating the severity of Ebstein anomaly. Preoperative cardiac CT ventricular volumetry was performed in 21 children with Ebstein anomaly. CT-based ventricular functional measures were compared between Carpentier types, and between definitive surgical repair types. The Celermajer severity inde...
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
“From Vision to Reality: Virtual Reality’s Impact on Baffle Planning in Congenital Heart Disease”
This study aims to evaluate the feasibility and utility of virtual reality (VR) for baffle planning in congenital heart disease (CHD), specifically by creating patient-specific 3D heart models and assessing a user-friendly VR interface. Patient-specific 3D heart models were created using high-resolution imaging data and a VR interface was developed for baffle planning. The process of model creation and the VR interface were assessed for their feasibility, usability, and clinical relevance. Collaborative and interactive planning within the VR space were also explored. The study findings demonstrate the feasibility and usefu...
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
Postoperative Troponin Levels in Children Undergoing Open Heart Surgery With and Without Coronary Intervention
AbstractWe aimed to characterize the ranges, temporal trends, influencing factors, and prognostic significance of postoperative troponin levels after congenital heart surgery. This single-center retrospective study included patients from 2006 to 2021 who had ≥ 1 postoperative troponin-T measurement collected within 96 h of congenital heart surgery (CHS). Patients were grouped as Anomalous Aortic Origin of the Coronary Artery—“AAOCA repair,” or congenital heart surgery with “Other Coronary Interventions” other than AAOCA repair, or “N o Coronary Intervention.” In each group, information on concomitant ...
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
Burden with No Benefit: Prior Authorization in Congenital Cardiology
AbstractPrior authorization is a process that health insurance companies use to determine if a patient ’s health insurance will cover certain medical treatments, procedures, or medications. Prior authorization requests are common in adult congenital and pediatric cardiology (ACPC) due to need for advanced diagnostics, complex procedures, disease-specific medications, and the heterogeneity of the AC PC population. Prior authorizations in ACPC are rarely denied, but nonetheless, they are often accompanied by significant administrative burden on clinical care teams and delays in patient care. Prior authorizations have been ...
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
Pre-operative Imaging of Critical Coarctation of the Aorta: Impact on Surgical Approach and Outcomes
AbstractComputed tomographic angiography (CTA) has been increasingly used for the evaluation of infants with aortic arch hypoplasia and coarctation of the aorta. The goals of this study were to compare echocardiographic and CTA findings in critical coarctation of the aorta, to evaluate each modality ’s influence on surgical approach for repair and determine if pre-operative measurements or surgical approach are associated with residual lesions/re-interventions. This was a single-center retrospective cohort study that included 85 neonates and infants who underwent repair of coarctation/arch hy poplasia by three months of ...
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
Risk Factors and Nomogram Model of Postoperative Delirium in Children with Congenital Heart Disease: A Single-Center Prospective Study
AbstractDelirium is a common postoperative complication in children with congenital heart disease, which affects their postoperative recovery. The purpose of this study is to explore the risk factors of delirium and construct a nomogram model to provide novel references for the prevention and management of postoperative delirium in children with congenital heart disease. 470 children after congenital heart surgery treated in the cardiac intensive care unit (CICU) of Shanghai Children ’s Medical Center were divided into a model and a validation cohort according to the principle of 7:3 distribution temporally. Then, the de...
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
Higher Cumulative Dose of Opioids and Other Sedatives are Associated with Extubation Failure in Norwood Patients
ConclusionHigher cumulative opioid doses were associated with a greater incidence of extubation failure in infants post-Norwood procedure. Therefore, patients with higher cumulative doses of opioids should be more closely evaluated for extubation readiness in this population. Low end-tidal CO2 and low pulse-to-respiratory quotient were also associated with failed extubation. Consideration of the pulse-to-respiratory quotient in the extubation readiness assessment can be beneficial in the Norwood population. (Source: Mammalian Genome)
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
Echocardiographic Mid-systolic Pulmonary Valve Notching in Extremely Low Gestational Age Neonates (ELGANs) with Severe Pulmonary Hypertension
(Source: Mammalian Genome)
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
Perivascular Basal Echogenicity in the Fetal Heart: An Unconventional Marker of Maternal Autoimmune Antibodies
We present two cases where recognition of isolated basal echogenicity of the fetal heart, an unconventional manifestation of anti-SSA antibodies during pregnancy, led to a suspicion and ultimately diagnosis of antibody positivity in the mother. These cases highlight the importance of being aware of this rare manifestation of anti-SSA antibodies during pregnancy, as early recognition of antibody positivity may lead to improve fetal and maternal outcomes. (Source: Mammalian Genome)
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
Letter Regarding “Ten-Year Follow-Up of Dilatation of Aortic Structures in Fallot-Type Anomalies”
(Source: Mammalian Genome)
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
Fontan Fenestration Reduction with an Occlutech Atrial Flow Regulator: Unique Views from Three-Dimensional Intracardiac Echocardiography
We describe the use of 3D ICE in the reduction of a Fontan fenestration with an Occlutech atrial flow regulator (AFR) device. (Source: Mammalian Genome)
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
Answer to Dr. Bassareo ’s Letter
(Source: Mammalian Genome)
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
