Aromatase Inhibitors May Increase the Risk of Cardiometabolic Complications in Adolescent Boys
ConclusionIncreased LVM, LVPWD, IVSD and Sm of patients receiving AI therapy in comparison to the control groups, and the significant correlations of these parameters with total testosterone and hemoglobin levels were determined as potential side effects of AIs. These findings emphasize the need of routine cardiac follow-up in patients using AIs. (Source: Mammalian Genome)
Source: Mammalian Genome - August 6, 2023 Category: Genetics & Stem Cells Source Type: research
Impact of Residual Lesion Severity on Neurodevelopmental Outcomes Following Congenital Heart Surgery in Infancy and Childhood
In conclusion, RLS 3 patients are at increased risk for neurodevelopmental delay, warranting closer follow-up and greater developmental support for cognitive, language, and motor skills soon after surgery. (Source: Mammalian Genome)
Source: Mammalian Genome - August 6, 2023 Category: Genetics & Stem Cells Source Type: research
Healthcare Use Among Black and White Congenital Heart Disease Medicaid Enrollees
This study examines racial differences in healthcare use among Medicaid-covered children with CHD. Using 2010 –2019 claims data from a pediatric Medicaid Accountable Care Organization, 960 Black and White children with complex CHD and ≥ 3 years of continuous Medicaid coverage were identified. Three cohorts were constructed (starting age: < 1-year-olds, 1–5-year-olds, 6–15-year-olds) and followed for 3 years. Multivariate analysis assessed annual healthcare use (cardiology, primary care, emergency department) by race, adjusting for patient and provider covariates. Overall, 51% of patients had an annual...
Source: Mammalian Genome - August 3, 2023 Category: Genetics & Stem Cells Source Type: research
Elevated Aortic Stiffness after Pediatric Heart Transplantation
AbstractIn adults, arterial stiffness has been linked to the development of target end-organ damage, thought to be related to abnormal transmission of pulse pressure. Increased arterial stiffness and endothelial dysfunction have been hypothesized to contribute to the development of microvascular dysfunction and coronary allograft vasculopathy (CAV), an important comorbidity after heart transplantation. However, little data exists regarding arterial stiffness in pediatric heart transplantation and its influence on development of coronary allograft vasculopathy is not well understood. We sought to assess aortic stiffness and...
Source: Mammalian Genome - August 3, 2023 Category: Genetics & Stem Cells Source Type: research
Correction: Novel Score to Predict Immunoglobulin Resistance in Kawasaki Disease
(Source: Mammalian Genome)
Source: Mammalian Genome - August 2, 2023 Category: Genetics & Stem Cells Source Type: research
A Prospective Evaluation of Arrhythmias in a Large Tertiary Neonatal Intensive Care Unit
AbstractArrhythmias in the neonatal period are common and can be classified as bradyarhythmias and tachyarrhythmias and as benign or non-benign. Neonatal arrhythmias are further differentiated between those with abnormalities in generation (non-sinus) and those with abnormalities in propagation. Because the neonatal myocardium is immature and operates at the peak of the Starling curve, significant changes in heart rate can result in a decline in cardiac output and compromise end-organ perfusion. This is especially true for premature neonates, those critically ill, or those with concomitant congenital heart disease. While s...
Source: Mammalian Genome - June 26, 2023 Category: Genetics & Stem Cells Source Type: research
Machine Learning to Predict Interstage Mortality Following Single Ventricle Palliation: A NPC-QIC Database Analysis
This study aimed to leverage advanced machine learning algorithms to optimize risk-prediction models and identify features most predictive of interstage mortality. This study utilized retrospective data from the National Pediatric Cardiology Quality Improvement Collaborative and included all patients who underwent stage I palliation and survived to hospital discharge (2008 –2019). Multiple machine learning models were evaluated, including logistic regression, random forest, gradient boosting trees, extreme gradient boost trees, and light gradient boosting machines. A total of 3267 patients were included with 208 (6.4%) i...
Source: Mammalian Genome - June 26, 2023 Category: Genetics & Stem Cells Source Type: research
Automatic Segmentation of the Fetus in 3D Magnetic Resonance Images Using Deep Learning: Accurate and Fast Fetal Volume Quantification for Clinical Use
This study also illustrates the confounding effects of fetal weight on absolute blood flow, and emphasizes the benefit of indexed measurements for physiological assessment. (Source: Mammalian Genome)
Source: Mammalian Genome - June 26, 2023 Category: Genetics & Stem Cells Source Type: research
Risk of in-hospital Deterioration for Children with Single Ventricle Physiology
AbstractChildren with single ventricle physiology (SV) are at high risk of in-hospital morbidity and mortality. Identifying children at risk for deterioration may allow for earlier escalation of care and subsequently decreased mortality.We conducted a retrospective chart review of all admissions to the pediatric cardiology non-ICU service from 2014 to 2018 for children < 18 years old. We defined clinical deterioration as unplanned transfer to the ICU or inpatient mortality. We selected children with SV by diagnosis codes and defined infants as children < 1 year old. We compared demographic, vital sign, and...
Source: Mammalian Genome - June 26, 2023 Category: Genetics & Stem Cells Source Type: research
Fetal Echocardiographic Variables Associated with Pre-Surgical Mortality in Truncus Arteriosus: A Pilot Study
AbstractTruncus arteriosus (TA) is a rare congenital heart defect that can be prenatally detected by fetal echocardiography. However, prognostication and prenatal counseling focus primarily on surgical outcomes due to limited fetal and neonatal pre-surgical mortality data. We aimed to describe the incidence and identify predictors of pre-surgical mortality in prenatally detected TA. This two-center, retrospective cohort study included fetuses diagnosed with TA between 01/2010 and 04/2020. The primary outcome was pre-surgical mortality, defined by fetal or neonatal pre-surgical death or primary listing for transplantation p...
Source: Mammalian Genome - June 26, 2023 Category: Genetics & Stem Cells Source Type: research
Virtually Delivered Psychosocial Intervention for Prenatally Diagnosed Congenital Heart Disease: Feasibility and Acceptability of HEARTPrep
This study evaluated the feasibility and acceptability of HEARTPrep. Participants were mothers receiving cardiology care for a fetal CHD diagnosis. Partners could participate with the mother. HEARTPrep was delivered through a mobile app and telehealth. Feasibility was assessed through enrollment/retention rates. Acceptability was assessed through 20 Likert-scale and five open-ended questions. Of 39 recruited mothers, 35 (90%) enrolled. Half of partners (48%) also participated. Twenty-seven of 35 enrolled mothers (77%) completed HEARTPrep. On a scale from 0 (Not at All) to 4 (Very), mean item acceptability scores ranged fro...
Source: Mammalian Genome - June 24, 2023 Category: Genetics & Stem Cells Source Type: research
Acute Kidney Injury and Mid-term Outcomes After Extra-Cardiac Fontan Conversion
In conclusion, postoperative acute kidney injury after extra-cardiac Fontan conversion was associated with unplanned re-admission due to heart failure at 2-year follow-up even though renal function was recovered. (Source: Mammalian Genome)
Source: Mammalian Genome - June 24, 2023 Category: Genetics & Stem Cells Source Type: research
Contemporary Outcomes in Fetuses Diagnosed with Vascular Rings
AbstractVascular rings are increasingly identified on fetal echocardiography. The purpose of this study is to analyze clinical outcomes and patterns of diagnostic testing in fetuses with vascular rings diagnosed by echocardiography. A retrospective cohort study was performed of fetuses with postnatally confirmed vascular rings from 2017 to 2022. Clinical outcomes included type and timing of symptoms, and timing of surgical intervention. Freedom from symptoms and/or surgery was assessed by Kaplan –Meier analysis. Frequency of genetic and diagnostic testing (barium esophagogram, CT/MRI angiogram, and bronchoscopy) was also...
Source: Mammalian Genome - June 24, 2023 Category: Genetics & Stem Cells Source Type: research
Impact of Right Ventricular Surface Area-to-Volume Ratio on Ventricular Remodeling After Pulmonary Valve Replacement
AbstractOptimal reverse remodeling of the right ventricle (RV), a sentinel goal of pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot, is not fully predicted by volume-based pre-PVR parameters. Our objectives were to characterize novel geometric RV parameters in patients receiving PVR and in controls, and to identify associations between these parameters and chamber remodeling post-PVR. Secondary analysis was performed on cardiac magnetic resonance (CMR) data from 60 patients enrolled in a randomized trial of PVR with and without surgical RV remodeling. 20 healthy age-matched subjects served as...
Source: Mammalian Genome - June 22, 2023 Category: Genetics & Stem Cells Source Type: research
Left Ventricular Function in Patients with Myopericarditis After mRNA COVID-19 Vaccination: Comment
(Source: Mammalian Genome)
Source: Mammalian Genome - June 22, 2023 Category: Genetics & Stem Cells Source Type: research
