Selected Abstracts from the PICS Society Symposium 2022 Marriott Chicago Downtown September 7 –10, 2022
(Source: Mammalian Genome)
Source: Mammalian Genome - September 1, 2022 Category: Genetics & Stem Cells Source Type: research
Evaluation of the Early Effects of Childhood Asthma and Its Treatment on Cardiac Function as Revealed by Two-Dimensional Speckle-Tracking Echocardiography
AbstractThere is minimal information available regarding the early effects of bronchial asthma (BA) and its treatment on cardiac function in children. We used two-dimensional speckle-tracking echocardiography (2D-STE) to evaluate cardiac function before and after the treatment of childhood BA. We enrolled 44 children with moderate and severe BA who had not been treated over the preceding 3 months or who were newly diagnosed. All children received the same treatment (that recommended by the Global Initiative for Asthma [GINA] in 2017). All children also underwent transthoracic 2D-STE before treatment and 6 months later. ...
Source: Mammalian Genome - August 29, 2022 Category: Genetics & Stem Cells Source Type: research
Optimizing 3D Rotational Angiography for Congenital Cardiac Catheterization
AbstractThe aim of the study was to determine the variables associated with high-quality (HQ) versus low-quality (LQ) three-dimensional rotational angiography (3DRA) and create guides for optimization of approach to 3DRA in congenital cardiac catheterization (CCC). CCC has adopted 3DRA as a mainstay, but there has not been systematic analysis of approach to and factors associated with HQ 3DRA. This was a single-center, retrospective study of 3DRAs using Canon Infinix-I platform. Reconstructions were graded by 3 interventionalists. Quality was dichotomized into HQ and LQ. Univariable analyses and multivariable logistic regr...
Source: Mammalian Genome - August 27, 2022 Category: Genetics & Stem Cells Source Type: research
Diastolic Function and Left Atrial Strain in Young Patients with History of Aortic Coarctation Repair
This study aims to describe these parameters in AoCo patients and define their association with severity measures. 53 AoCo patients and 31 healthy controls, aged 12 –40 years, were evaluated. Effectively corrected AoCo (cAoCo) was defined as aortic trans-isthmic corrected Doppler gradient (Dgrad) ≤ 20 mmHg (n = 36), and recoarctation (rAoCo) as Dgrad > 20 mmHg (n = 17). Dependent variables were: E/E’; atrial reservoir strain (Ares); and atrial conduit strain (Acd). T-tests/Mann–Whitney U tests were used to compare these among groups. Multivariable regression was used to test correlation with ...
Source: Mammalian Genome - August 26, 2022 Category: Genetics & Stem Cells Source Type: research
Accuracy of the Apple Watch Oxygen Saturation Measurement in Adults and Children with Congenital Heart Disease
AbstractAs new customer health devices have been spread throughout the consumer market in recent years, it now needs to be evaluated if they also fulfill the requirements of clinical use. The Apple Watch Series 6 provides a new health feature with its oxygen saturation measurement. The aim of this prospective, investigator-initiated, single-arm study was to compare transcutaneous oxygen saturation measurements using the Apple Watch 6 with the conventional method of pulse oximetry in patients with congenital heart disease. Patients of any age presenting at the Leipzig Heart Center, Department for pediatric cardiology, were ...
Source: Mammalian Genome - August 22, 2022 Category: Genetics & Stem Cells Source Type: research
Ross Operation in Pediatric Population: Impact of the Surgical Timing and the Native Pulmonary Diameter on the Outcome
We present our 25 years of experience in the pediatric population. From August 1994 until June 2018, 157 children below 18 years underwent the Ross operation. This retrospective review aims at assessing the long-term outcomes, as well as the risk factors for re-operation after Ross procedure. Median age was 10.9 years, of which seven patients were infants, 79 children, and 71 adolescents. The median follow-up time was 14 years. Hospital mortality was 0.6%. Freedom from autograft re-operation for children was 96.7% and 94.1% at 10 and 20 years, respectively; whereas for adolescents, it was 92.6% and 74.9% at 10 and 2...
Source: Mammalian Genome - August 22, 2022 Category: Genetics & Stem Cells Source Type: research
Pulmonary Venous Gradients in Healthy Controls and Following the Repair of Total Anomalous Pulmonary Venous Return
AbstractThe percent of children who can achieve a normal and physiologic pulmonary venous gradient and flow following the repair of Total Anomalous Pulmonary Venous Return (TAPVR) is not known. Pulmonary venous confluence gradients from infants with supra-, infra-, or mixed TAPVR, repaired using a direct anastomotic connection were measured. Data from age, weight, and gender-matched controls established the normal pulmonary venous gradient range (0.30 –0.94 mmHg). TAPVR subjects were divided into three groups: (I) pulmonary venous gradient < 2 × normal with multiphasic flow (II) pulmonary venous gradient &g...
Source: Mammalian Genome - August 20, 2022 Category: Genetics & Stem Cells Source Type: research
A Novel Marker for Predicting Fulminant Myocarditis: Systemic Immune –Inflammation Index
This study aims to (1) determine the effect of SII and other inflammatory markers on the prognosis of patients with myocarditis, and (2) characterize other factors affectin g adverse outcomes in myocarditis. All patients aged between 1 months and 18 years who admitted to Pediatric Emergency Department between January 1, 2015 and October 1, 2021 and were diagnosed with myocarditis were retrospectively analyzed. 106 Eligible subjects were enrolled (67% male, 12.5 year s (IQR 6–16). Fulminant myocarditis developed in 16 (15%) of the patients. The median SII was 1927 (1147.75–3610.25) in the fulminant myocarditis group ...
Source: Mammalian Genome - August 19, 2022 Category: Genetics & Stem Cells Source Type: research
Heart Failure with Preserved Ejection Fraction in Children
AbstractDiastolic dysfunction (DD) refers to abnormalities in the mechanical function of the left ventricle (LV) during diastole. Severe LVDD can cause symptoms and the signs of heart failure (HF) in the setting of normal or near normal LV systolic function and is referred to as diastolic HF or HF with preserved ejection fraction (HFpEF). Pediatric cardiologists have long speculated HFpEF in children with congenital heart disease and cardiomyopathy. However, understanding the risk factors, clinical course, and validated biomarkers predictive of the outcome of HFpEF in children is challenging due to heterogeneous etiologies...
Source: Mammalian Genome - August 17, 2022 Category: Genetics & Stem Cells Source Type: research
Implications of Transfusion in Adults with Congenital Heart Disease Undergoing Cardiac Surgery
AbstractThe number of adults with congenital heart disease (CHD) requiring cardiovascular (CV) surgery is increasing rapidly in today ’s era. We hypothesized that exposure to perioperative blood products is associated with worse outcomes in adults. All adults (≥ 18 years old) undergoing CV surgery with Cardio-Pulmonary Bypass (CPB) between 2015 and 2020 were reviewed retrospectively. Associations between transfusion and out comes were studied by univariable logistic regression and Wilcoxon rank sum tests. Cox/ logistic regression was used to assess (a) postoperative ventilation time and length of stay, and (b) major...
Source: Mammalian Genome - August 13, 2022 Category: Genetics & Stem Cells Source Type: research
Telehealth and Application of Appropriate Use Criteria for Pediatric Transthoracic Echocardiography
AbstractAppropriate use criteria (AUC) for the performance of outpatient transthoracic echocardiography are based on history, physical examination and electrocardiograms. Telehealth provides access to clinical care in the absence of a physical examination. We assessed application of AUC for performance of echocardiography following a telehealth visit. In this single center study, we retrospectively reviewed the charts of pediatric patients whose originally scheduled in person visits were converted to telehealth visits between March and May 2020. Patients were referred for echocardiogram by the telehealth cardiologist. Echo...
Source: Mammalian Genome - August 12, 2022 Category: Genetics & Stem Cells Source Type: research
Physicians ’ Self-reported Exercise Testing and Physical Activity Recommendations in Kawasaki Patients
This study aimed to characterize self-reported practices of KD providers to evaluate practice variation in use of cardiopulmonary exercise testing (CPET) and PA recommendations. We developed a REDCap survey with different clinical scenarios of KD patients. It was completed by members of the International Kawasaki Disease Registry (IKDR) and community pediatric cardiologists. Twenty-eight physicians responded; 63% practiced in the US, 63% practiced in an academic setting, 48% were general pediatric cardiologists, and 55% were IKDR members. Most respondents (69%) followed < 50 KD patients. The great majority (93%) a...
Source: Mammalian Genome - August 11, 2022 Category: Genetics & Stem Cells Source Type: research
Long-Term Influence of Atrial Switch Operation on Hemodynamics After the Rastelli Procedure
AbstractThe study aimed to investigate the long-term influence of atrial switch on post-Rastelli hemodynamic condition. Of 112 patients with transposition of the great arteries (TGA) or TGA-type double outlet right ventricle, ventricular septal defect (VSD), and pulmonary stenosis (PS) who underwent intra-cardiac repair between 1979 and 2018, 50 patients with levo-TGA underwent atrial switch and Rastelli as an anatomic repair and 62 patients with dextro-TGA underwent Rastelli. Postoperative outcomes were retrospectively compared. The median follow-up durations were 20.1 years (interquartile range: 4.3, 32.4) in the Raste...
Source: Mammalian Genome - August 9, 2022 Category: Genetics & Stem Cells Source Type: research
Double Aortic Arch with Atresia of the Left Aortic Arch Proximal to the Left Common Carotid Artery: First Report of Documentation by Surgical Observation
AbstractDouble aortic arch associated with atresia of the left arch proximal to the left common carotid artery has been considered a theoretical possibility. To our knowledge, we report the first patient with this anatomy confirmed by surgical observation. (Source: Mammalian Genome)
Source: Mammalian Genome - August 5, 2022 Category: Genetics & Stem Cells Source Type: research
Kawasaki Disease Arab Initiative [Kawarabi]: Establishment and Results of a Multicenter Survey
AbstractStudies on Kawasaki disease (KD) in Arab countries are scarce, often providing incomplete data. This along with the benefits of multicenter research collaboratives led to the creation of the KD Arab Initiative [Kawarabi] consortium. An anonymous survey was completed among potential collaborative Arab medical institutions to assess burden of KD in those countries and resources available to physicians. An online 32-item survey was distributed to participating institutions after conducting face validity. One survey per institution was collected. Nineteen physicians from 12 countries completed the survey representing 1...
Source: Mammalian Genome - July 18, 2022 Category: Genetics & Stem Cells Source Type: research
