Automatic Segmentation of the Fetus in 3D Magnetic Resonance Images Using Deep Learning: Accurate and Fast Fetal Volume Quantification for Clinical Use
This study also illustrates the confounding effects of fetal weight on absolute blood flow, and emphasizes the benefit of indexed measurements for physiological assessment. (Source: Mammalian Genome)
Source: Mammalian Genome - June 26, 2023 Category: Genetics & Stem Cells Source Type: research
Risk of in-hospital Deterioration for Children with Single Ventricle Physiology
AbstractChildren with single ventricle physiology (SV) are at high risk of in-hospital morbidity and mortality. Identifying children at risk for deterioration may allow for earlier escalation of care and subsequently decreased mortality.We conducted a retrospective chart review of all admissions to the pediatric cardiology non-ICU service from 2014 to 2018 for children < 18 years old. We defined clinical deterioration as unplanned transfer to the ICU or inpatient mortality. We selected children with SV by diagnosis codes and defined infants as children < 1 year old. We compared demographic, vital sign, and...
Source: Mammalian Genome - June 26, 2023 Category: Genetics & Stem Cells Source Type: research
Fetal Echocardiographic Variables Associated with Pre-Surgical Mortality in Truncus Arteriosus: A Pilot Study
AbstractTruncus arteriosus (TA) is a rare congenital heart defect that can be prenatally detected by fetal echocardiography. However, prognostication and prenatal counseling focus primarily on surgical outcomes due to limited fetal and neonatal pre-surgical mortality data. We aimed to describe the incidence and identify predictors of pre-surgical mortality in prenatally detected TA. This two-center, retrospective cohort study included fetuses diagnosed with TA between 01/2010 and 04/2020. The primary outcome was pre-surgical mortality, defined by fetal or neonatal pre-surgical death or primary listing for transplantation p...
Source: Mammalian Genome - June 26, 2023 Category: Genetics & Stem Cells Source Type: research
Virtually Delivered Psychosocial Intervention for Prenatally Diagnosed Congenital Heart Disease: Feasibility and Acceptability of HEARTPrep
This study evaluated the feasibility and acceptability of HEARTPrep. Participants were mothers receiving cardiology care for a fetal CHD diagnosis. Partners could participate with the mother. HEARTPrep was delivered through a mobile app and telehealth. Feasibility was assessed through enrollment/retention rates. Acceptability was assessed through 20 Likert-scale and five open-ended questions. Of 39 recruited mothers, 35 (90%) enrolled. Half of partners (48%) also participated. Twenty-seven of 35 enrolled mothers (77%) completed HEARTPrep. On a scale from 0 (Not at All) to 4 (Very), mean item acceptability scores ranged fro...
Source: Mammalian Genome - June 24, 2023 Category: Genetics & Stem Cells Source Type: research
Acute Kidney Injury and Mid-term Outcomes After Extra-Cardiac Fontan Conversion
In conclusion, postoperative acute kidney injury after extra-cardiac Fontan conversion was associated with unplanned re-admission due to heart failure at 2-year follow-up even though renal function was recovered. (Source: Mammalian Genome)
Source: Mammalian Genome - June 24, 2023 Category: Genetics & Stem Cells Source Type: research
Contemporary Outcomes in Fetuses Diagnosed with Vascular Rings
AbstractVascular rings are increasingly identified on fetal echocardiography. The purpose of this study is to analyze clinical outcomes and patterns of diagnostic testing in fetuses with vascular rings diagnosed by echocardiography. A retrospective cohort study was performed of fetuses with postnatally confirmed vascular rings from 2017 to 2022. Clinical outcomes included type and timing of symptoms, and timing of surgical intervention. Freedom from symptoms and/or surgery was assessed by Kaplan –Meier analysis. Frequency of genetic and diagnostic testing (barium esophagogram, CT/MRI angiogram, and bronchoscopy) was also...
Source: Mammalian Genome - June 24, 2023 Category: Genetics & Stem Cells Source Type: research
Impact of Right Ventricular Surface Area-to-Volume Ratio on Ventricular Remodeling After Pulmonary Valve Replacement
AbstractOptimal reverse remodeling of the right ventricle (RV), a sentinel goal of pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot, is not fully predicted by volume-based pre-PVR parameters. Our objectives were to characterize novel geometric RV parameters in patients receiving PVR and in controls, and to identify associations between these parameters and chamber remodeling post-PVR. Secondary analysis was performed on cardiac magnetic resonance (CMR) data from 60 patients enrolled in a randomized trial of PVR with and without surgical RV remodeling. 20 healthy age-matched subjects served as...
Source: Mammalian Genome - June 22, 2023 Category: Genetics & Stem Cells Source Type: research
Left Ventricular Function in Patients with Myopericarditis After mRNA COVID-19 Vaccination: Comment
(Source: Mammalian Genome)
Source: Mammalian Genome - June 22, 2023 Category: Genetics & Stem Cells Source Type: research
Multisystem Inflammatory Syndrome in Children (MIS-C): Reduced Exercise Duration and Capacity at Six Month Follow-Up
AbstractMyocarditis is common in Multisystem Inflammatory Syndrome in Children (MIS-C), and the mechanism may differ from idiopathic/viral myocarditis as MIS-C involves a hyper-inflammatory state weeks after COVID-19. We sought to evaluate exercise stress testing (EST) in these patients as EST may help guide return-to-play recommendations. Retrospective cohort study evaluating ESTs (standard Bruce treadmill protocol) from MIS-C patients from 2020 to 2022, compared to myocarditis patients and age, sex, and weight matched controls from 2005 to 2019. ESTs included 22 MIS-C patients (mean age 11.9 years) with 14 cardiopulmonar...
Source: Mammalian Genome - June 21, 2023 Category: Genetics & Stem Cells Source Type: research
Living with Congenital Aortic Stenosis: Exercise Restriction, Patterns of Adherence, and Quality of Life
In this study, we surveyed 93 subjects with AS and their cardiologists regarding participation in organized sports, physical activity, weightlifting, and exercise restriction. Subjects completed the pediatric quality of life inventory (PedsQL) and the pediatric cardiac quality of life inventory (PCQLI). We found that subjects with severe AS (n = 3) were commonly, but not universally, restricted from organized sports (n = 2, 66%). Subjects with moderate AS (n = 40) were rarely restricted from organized sports (n = 6, 17%). No physician-specific characteristics were associated with increased likelihood of rec...
Source: Mammalian Genome - June 21, 2023 Category: Genetics & Stem Cells Source Type: research
Correction to: Fetal Tricuspid Valve Agenesis/Atresia: Testing Predictions of the Embryonic Etiology
(Source: Mammalian Genome)
Source: Mammalian Genome - June 20, 2023 Category: Genetics & Stem Cells Source Type: research
Evaluating How Physician Attitudes May Affect Practice in Fetal Cardiac Counseling
AbstractAdvances in fetal cardiac imaging over the last few decades have allowed for increased prenatal detection and detailed counseling of congenital heart disease (CHD). When CHD is detected, fetal cardiologists are faced with the challenge of providing nuanced prenatal counseling. Studies in other specialties have shown that differences in physician attitudes exist around termination of pregnancy and correlate with variations in the counseling provided to parents. We conducted an anonymous cross-sectional survey of fetal cardiologists in New England (n = 36) regarding attitudes toward termination of pregnancy and t...
Source: Mammalian Genome - June 19, 2023 Category: Genetics & Stem Cells Source Type: research
Association Between Race/Ethnicity and Severity of Illness in Pediatric Cardiomyopathy and Myocarditis
Conclusion: Black patients have higher severity of illness on firs t admission to the ICU, which may reflect differences in access to care. Black patients are less likely to receive a heart transplant. Additionally, Black patients and those with unreported race/ethnicity had higher odds of CPR, which was not mediated by severity of illness, suggesting variations in care may persist after admission. (Source: Mammalian Genome)
Source: Mammalian Genome - June 17, 2023 Category: Genetics & Stem Cells Source Type: research
Challenges in Accurate Diagnosis of HCC in FALD: A Case Series
We present 6 cases to demonstrate our center ’s experience and the challenges in diagnosing HCC within this patient population. (Source: Mammalian Genome)
Source: Mammalian Genome - June 15, 2023 Category: Genetics & Stem Cells Source Type: research
Comparative Effectiveness of Surgical Ligation and Catheter Closure of Patent Ductus Arteriosus in Preterm Infants
AbstractTo evaluate the association, if any, between closure modality (surgical ligation SL vs. catheter CC) of a hemodynamically significant patent ductus arteriosus (PDA), after failure of or contraindication to medical therapy, and immediate procedural complications, and post-procedure physiologic status in preterm (gestational age < 32 weeks) infants. In this single-center retrospective cohort study, data were accessed on infants < 32 weeks gestation, who underwent SL or CC of PDA, born from 2019–2021. The choice of modality was determined by parents, after they were provided information on both pr...
Source: Mammalian Genome - June 14, 2023 Category: Genetics & Stem Cells Source Type: research
