Autologous Cardiac Stem Cell Injection in Patients with Hypoplastic Left Heart Syndrome (CHILD Study)
AbstractMortality in infants with hypoplastic left heart syndrome (HLHS) is strongly correlated with right ventricle (RV) dysfunction. Cell therapy has demonstrated potential improvements of RV dysfunction in animal models related to HLHS, and neonatal human derived c-kit+ cardiac-derived progenitor cells (CPCs) show superior efficacy when compared to adult human cardiac-derived CPCs (aCPCs). Neonatal CPCs (nCPCs) have yet to be investigated in humans. The CHILD trial (AutologousCardiac Stem Cell Injection in Patients withHypoplasticLeft Heart Syndrome) is a Phase I/II trial aimed at investigating intramyocardial administr...
Source: Mammalian Genome - April 8, 2022 Category: Genetics & Stem Cells Source Type: research
Ventricular Arrhythmias and Sudden Death Following Percutaneous Pulmonary Valve Implantation in Pediatric Patients
AbstractReports have suggested a transient increase in ventricular ectopy early after percutaneous pulmonary valve implantation (PPVI). Little is known about the potential for more serious ventricular arrhythmias (VA) in children who undergo PPVI. We sought to evaluate the incidence of severe VA following PPVI in a pediatric population and to explore potential predictive factors. A retrospective cohort study was conducted of patients who underwent PPVI under 20 years of age in our institution from January 2007 to December 2019. The primary outcome of severe VA was defined as sustained and/or hemodynamically unstable vent...
Source: Mammalian Genome - April 8, 2022 Category: Genetics & Stem Cells Source Type: research
Electrocardiography is Unreliable to Detect Potential Lethal Hyperkalemia in Patients with Non-dialysis Chronic Kidney Disease
This study was conducted to determine whether electrocardiography (ECG) is a reliable indicator to detect severe life-threatening hyperkalemia in non-dialysis CKD patients. The study was conducted at three referral university hospitals between July 2017 and June 2018. Severe hyperkalemia was defined as serum potassium concentration ≥ 8.0 mEq/L. Serum potassium, sodium, bicarbonate, calcium, and creatinine concentrations were measured and simultaneous 12-lead ECG was obtained. Patients with end-stage renal disease receiving renal replacement therapy were excluded. Also excluded were patients with the usual ECG abnormal...
Source: Mammalian Genome - April 7, 2022 Category: Genetics & Stem Cells Source Type: research
Upcoming Events in Pediatric Cardiology
(Source: Mammalian Genome)
Source: Mammalian Genome - April 7, 2022 Category: Genetics & Stem Cells Source Type: research
Intrauterine Growth Restriction: An Emerging Cardiovascular Risk Factor
(Source: Mammalian Genome)
Source: Mammalian Genome - April 6, 2022 Category: Genetics & Stem Cells Source Type: research
