Children with Congenital Heart Disease Show Increased Behavioral Problems Compared to Healthy Peers: A Systematic Review and Meta-Analysis
AbstractMillions of children and adults are living with congenital heart disease (CHD). Their risk for behavioral problems has not been the subject of a meta-analysis. We performed a systematic review and meta-analysis of measures of behavioral problems in people born with CHD compared to peers without CHD. We searched Pubmed, CINAHL, Embase, PsycInfo, and the Cochrane Library from January 1, 1986 to November 15, 2021. We included studies that reported a measure of behavioral problems in patients with CHD in children and adults older than 3 years of age. We screened 26,343 search results, and 24 studies met inclusion cri...
Source: Mammalian Genome - June 4, 2022 Category: Genetics & Stem Cells Source Type: research
Prevalence and Associated Factors of Long-term Growth Failure in Infants with Congenital Heart Disease Who Underwent Cardiac Surgery Before the Age of One
AbstractLong-term growth failure can have negative impact on health (by increasing morbidity and mortality) and on neurodevelopmental outcomes. Its prevalence among children with congenital heart disease (CHD) is not well described. The aim of our study was to evaluate the prevalence of growth failure in a population of infants with CHD away from cardiac surgery and identify associated factors. We conducted a retrospective and multicentric study that included infants from the North of France who underwent cardiac surgery before the age of one, between January 2013 and December 2017. 331 infants were included among which 48...
Source: Mammalian Genome - June 4, 2022 Category: Genetics & Stem Cells Source Type: research
Long QT and Hearing Loss in High-Risk Infants Prospective Study Registry
The objective of this study is to determine the prevalence of an abnormal electrocardiogram showing a prolonged QTc greater than 450 ms in infants with unilateral or bilateral sensorineural hearing loss. We conducted a prospective study of healthy term infants (≥37 weeks gestational age) who failed their newborn auditory brainstem response hearing screen, were seen by an audiologist and diagnosed as having sensorineural hear ing loss during follow-up to 1 year of age. In infants with a diagnosis of hearing loss, we collected a detailed family history and performed an ECG between 2 and 6 months of age. We obtained fol...
Source: Mammalian Genome - June 3, 2022 Category: Genetics & Stem Cells Source Type: research
Age Difference of the Relationship Between Cerebral Oxygen Saturation and Physiological Parameters in Pediatric Cardiac Surgery with Cardiopulmonary Bypass: Analysis Using the Random-Effects Model
AbstractRecently, monitoring of cerebral oxygen saturation (ScO2) has become widespread in pediatric cardiac surgery. Our previous study reported that mean blood pressure (mBP) was the major contributor to ScO2 throughout cardiac surgery with cardiopulmonary bypass (CPB) in children weighing under 10 kg. We speculated that this result might be attributable to incomplete cerebral autoregulation in such young children. Accordingly, our hypothesis is that the relationship between ScO2 and the physiological parameters may change according to the growth of the children. ScO2 was measured with an INVOS 5100C (Somanetics, Troy,...
Source: Mammalian Genome - June 3, 2022 Category: Genetics & Stem Cells Source Type: research
Tricuspid Valve Endocarditis in Four Patients with Unrepaired Restrictive Perimembranous Ventricular Septal Defects
We present a case series of four children with small, restrictive, perimembranous VSDs who developed tricuspid valve (TV) IE. All four experienced delayed diagnosis and secondary complications, including three with septic pulmonary emboli. All four patients ultimately underwent surgical VSD closure. These cases highlight the importance of recognizing IE as a possible cause of prolonged fever in children, even among those with even ‘low-risk’ CHD. The cases also draw attention to the potential benefits of VSD closure in patients who develop IE. (Source: Mammalian Genome)
Source: Mammalian Genome - June 3, 2022 Category: Genetics & Stem Cells Source Type: research
Health Disparities in the Treatment of Supraventricular Tachycardia in Pediatric Patients
This study adds evidence to the presence of inequities in health care delivery across pediatric populations. (Source: Mammalian Genome)
Source: Mammalian Genome - May 10, 2022 Category: Genetics & Stem Cells Source Type: research
Predictive Value of Plasma Copeptin Level in Children with Acute Heart Failure
AbstractWe investigated the ability of copeptin level to predict adverse outcome in pediatric heart failure (HF) and correlated copeptin level with various clinical and echocardiographic data. This cohort study was carried out on forty children with clinical picture of acute HF as the patient group and forty healthy children of matched age and sex as the control group. Echocardiographic examination and plasma copeptin level were performed for all included children at admission. Patients were followed up for 6 months for mortality or readmission. Plasma copeptin level was significantly higher in the patient group (16.2...
Source: Mammalian Genome - May 9, 2022 Category: Genetics & Stem Cells Source Type: research
Outcomes of Extracorporeal Membrane Oxygenation in Patients After Repair of Congenital Heart Defects
AbstractExtracorporeal membrane oxygenation (ECMO) is widely used after congenital heart surgery. The purpose of this study is to analyze the factors influencing mortality and morbidity in patients who require ECMO support after congenital cardiac surgery. All 109 patients (5.8% of total cases) who underwent ECMO support after congenital heart surgery between January 2014 and 2021 were included in this single-center study. The mean age was 10.13 ± 20.55 months, and the mean weight was 6.41 ± 6.79 kg. 87 (79.8%) of the patients were under 1 year of age. A total of 54 patients (49.5%) were weaned successfully fr...
Source: Mammalian Genome - May 9, 2022 Category: Genetics & Stem Cells Source Type: research
Hemodynamic Response to Fluid Boluses in Patients with Single-Ventricle Parallel Circulation
This study demonstrates that fluid boluses are an effective rescue medication for hypotensive episodes in children with parallel circulati on by improving hemodynamics, as well as markers of oxygen delivery. The type of bolus (normal saline versus albumin) did not affect the blood pressure response. However, normal saline had a more pronounced effect on the renal and cerebral oxygen extraction ratios than albumin. (Source: Mammalian Genome)
Source: Mammalian Genome - May 5, 2022 Category: Genetics & Stem Cells Source Type: research
The Surprise Question as a Trigger for Primary Palliative Care Interventions for Children with Advanced Heart Disease
This study evaluates the utility of the surprise question —“Would you be surprised if this child died within the next year? ”—to predict one-year mortality in children with AHD and assess its utility as entry criteria for future trials. This is a prospective cohort study of physicians and nurses caring for children (1 month–19 years) with AHD hospitalized ≥ 7 days. AHD was defined as single ventricle physiolo gy, pulmonary vein stenosis or pulmonary hypertension, or any cardiac diagnosis with signs of advanced disease. Primary physicians were asked the surprise question and medical record review was perf...
Source: Mammalian Genome - May 3, 2022 Category: Genetics & Stem Cells Source Type: research
Medium-Term Cardiac Outcomes in Young People with Multi-system Inflammatory Syndrome: The Era of COVID-19
AbstractMulti-system inflammatory syndrome in children (MIS-C) causes widespread inflammation including a pancarditis in the weeks following a COVID infection. As we prepare for further coronavirus surges, understanding the medium-term cardiac impacts of this condition is important for allocating healthcare resources. A retrospective single-center study of 67 consecutive patients with MIS-C was performed evaluating echocardiographic and electrocardiographic (ECG) findings to determine the point of worst cardiac dysfunction during the admission, then at intervals of 6 –8 weeks and 6–8 months. Worst cardiac function oc...
Source: Mammalian Genome - April 29, 2022 Category: Genetics & Stem Cells Source Type: research
Exercise Capacity After Arterial Switch Operation in Patients with D-Transposition of Great Arteries: Does the Coronary Artery Anatomy Matter?
AbstractVariant coronary anatomy (VarCA) is frequent in D-Transposition of the great arteries (d-TGA). There are a paucity of data on the effect of the VarCA on the exercise capacity (XC) in patients with repaired d-TGA. This retrospective study included patients with d-TGA who underwent an arterial switch operation (ASO) and had at least one cardiopulmonary exercise test (CPET). Data from the treadmill CPET and simultaneously performed spirometry were collected. The parameters of CPET were compared between patients with usual anatomy vs. VarCA. Longitudinal changes in XC in patients with ASO were also analyzed. A total of...
Source: Mammalian Genome - April 28, 2022 Category: Genetics & Stem Cells Source Type: research
Pulse Wave Velocity Measurements by Magnetic Resonance Imaging in Neonates and Adolescents: Methodological Aspects and Their Clinical Implications
This study is a step toward standardization of PWV in neonates and adolescents using CMR. It provides required temporal resolution for phase-contrast flow acquisitions for typical heartrates in neonates and adolescents, and supports 3D angiography and time-to-foot with automatic baseline correction for accurate PWV measurements. (Source: Mammalian Genome)
Source: Mammalian Genome - April 9, 2022 Category: Genetics & Stem Cells Source Type: research
Multiple Giant Coronary Artery Aneurysms in a Pediatric Patient with Granulomatosis with Polyangiitis
We report a case of a 14-year-old male who presented with a 1 month history of fatigue and shortness of breath. He ultimately was found to have multiple giant coronary aneurysms in both the left and right coronaries including a giant aneurysm in the posterior descending; this has not been previously reported. The case highlights the need for complete multi-m odality imaging of the coronary arteries in patients with GPA. (Source: Mammalian Genome)
Source: Mammalian Genome - April 9, 2022 Category: Genetics & Stem Cells Source Type: research
Impact of Sex and Obesity on Echocardiographic Parameters in Children and Adolescents
AbstractSubclinical alterations in left ventricular structure and function are detectable in adolescents with hypertension or obesity. However, data on early echocardiographic abnormalities in seemingly healthy children are lacking. Sex differences in cardiac structure and function have been previously reported, but sex-specific reference values are not available. Specifically, the potential interaction of sex and overweight has not been addressed at all. Anthropometric data, blood pressure and exercise tests were obtained in 356 healthy children. Echocardiographic parameters comprised peak early (E) and late (A) mitral in...
Source: Mammalian Genome - April 8, 2022 Category: Genetics & Stem Cells Source Type: research
