Postoperative Troponin Levels in Children Undergoing Open Heart Surgery With and Without Coronary Intervention

AbstractWe aimed to characterize the ranges, temporal trends, influencing factors, and prognostic significance of postoperative troponin levels after congenital heart surgery. This single-center retrospective study included patients from 2006 to 2021 who had  ≥ 1 postoperative troponin-T measurement collected within 96 h of congenital heart surgery (CHS). Patients were grouped as Anomalous Aortic Origin of the Coronary Artery—“AAOCA repair,” or congenital heart surgery with “Other Coronary Interventions” other than AAOCA repair, or “N o Coronary Intervention.” In each group, information on concomitant surgery requiring one or more of the following—atriotomy, ventriculotomy, right ventricular muscle bundle resection, and/or septal myectomy—was collected. Clinical correlates of troponin values were analyzed in three postopera tive windows: <  8, 8–24, and 24–48 h. The highest median [range] troponin levels (ng/mL) for the samples were 0.34 [0.06, 1.32] at <  8 h for “AAOCA repair,” 1.35 [0.14, 12.0] at <  8 h for those undergoing CHS with “Other Coronary Interventions,” and 0.87 [0.06, 25.1] at 8–24 h for those undergoing CHS with “No Coronary Interventions.” Atriotomy was associated with higher median troponin levels in the AAOCA group at <  8 h (0.40 [0.31, 0.77] vs. 0.29 [0.17, 0.54],P = 0.043) and in the Other Coronary Intervention group at 8–24 h (1.67 [1.04, 2.63] vs. 0.40 [0.19, 1.32],P ...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research