27 Characteristics of lung cancer diagnosed through a Rapid Diagnostic Clinic
Emergency presentation as the first diagnosis of cancer is associated with poorer patient outcomes and experience. To mitigate this, the NHS Faster Diagnostic Framework recommends Rapid Diagnostic Clinics (RDCs) for the investigation of non-specific symptoms. The Chelsea& Westminster Rapid Diagnostic Clinic (CW-RDC) was set up in 2015 for patients with suspected cancer and non-specific symptoms, who do not meet 2WW criteria nor warrant emergency admission. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Yarden Toiber-Kent, Rachel Sharkey, Muhammad Mohsin, Iris Soteriou, Abhjit Gill, Baldeep Syan, Nikita Shah, Lucy Sneddon, Ravindhi Murphy, Tom Newsom-Davis, Amit Samani Tags: Clinical Networks and Pathways Source Type: research
28 Impact of a Radiology cancer navigator role in conjunction with a chest reporting radiographer service on the lung cancer pathway
The patient journey through diagnosis& treatment for suspected lung cancer is complex. The journey usually begins with a GP requested chest x-ray and the pathway can be prolonged& confusing for patients. The introduction of the Single Cancer Pathway has further highlighted the need to improve the time to diagnostic tests and streamline the process for patient and MDT. We redesigned the service within the radiology service with the incorporation of 2 roles; that of an advanced practitioner navigator and a reporting radiographer. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Jamie White Tags: Clinical Networks and Pathways Source Type: research
29 Reorganising weekly rapid access lung cancer clinic into daily could help to implement best practice timed lung cancer pathway and meet faster diagnosis standard
Despite the lung pathway mapping work undertaken in recent years, implementing best practice time lung cancer pathway and achieving faster diagnosis standard (FDS) remains a challenge. Current set up of rapid access lung cancer clinics on certain fixed week days still leaves a gap when patients would be waiting for an appointment despite the CT scan results available. Aim: To evaluate impact of setting daily lung cancer clinic on lung cancer pathway times. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Vytis Dudzevicius, Andrea Charles, Joanne Barnett, Lisa Kay, Jessica Ainsley, Katie Fryett, Rehan Mustafa, Sathyamurthy Ramamurthy, Victoria Ashmore, Kerry Linkin, Carol Taylor Tags: Clinical Networks and Pathways Source Type: research
30 Outcomes and Patient Satisfaction from an Established Virtual Lung Nodule Clinic (II) at Torbay Hospital, Devon
Lung nodules identified from CT examination are common, often resulting in over investigation. Extended follow up periods and hospital attendance can lead to patient anxiety and inconvenience, with an impact on quality of life and demand on resources. In 2018 it was found the Virtual Lung Nodule Clinic (VLNC) was a streamlined service, reducing the need for multiple face to face appointments, with high patient satisfaction. As current literature suggests those of increased age and comorbidity are more likely to die from a cause other than their lung nodule, we aim to describe patient satisfaction through questionnaires but...
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Michael Dawson, Alex Wood, Fern Galloway, Dhruvesh Patel Tags: Clinical Networks and Pathways Source Type: research
31 The Nodules of Norfolk, Setting up a Pulmonary Nodule Pathway in a secondary care setting at the Norfolk & Norwich University Hospital – A reflective study over one year from January 2023 – January 2024
The Nodules of Norfolk, Setting up a Pulmonary Nodule Pathway in a secondary care setting at the Norfolk& Norwich University Hospital – A reflective study over one year January 2023–January 2024. The measures in the GIRFT report aim to ensure faster diagnoses and more effective treatment for patients with lung cancer. A recommendation for our trust was to “Commission a specific, robust, and predominantly virtual nodule pathw ay which is separate from the lung cancer MDT”. At the beginning of 2023 we successfully, not without its challenges, implemented the Pulmonary Nodule Pathway. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Charlotte Smith, Michael Crawford, Russell Phillips Tags: Clinical Networks and Pathways Source Type: research
32 Targeted social media adverts to drive attendance to a self-request chest x-ray service in Greater Manchester
To support the self-request chest x-ray (SRCXR) service in two localities of Greater Manchester (GM), an effective communications strategy is required. The main communication objective is to ensure that members of the public in the eligible areas are aware of the service and attend when appropriate. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Alison Foxley, Michael Armstrong, Bobby SK Bhartia, Matthew Evison, Seamus Grundy, Rehan Naseer, Anna Perkins, Leonie Smedley Tags: Clinical Networks and Pathways Source Type: research
33 Implementation of a Lung Oncology Virtual Ward (VW) – Accelerating Responsiveness to Personalised Care Management
Lung Cancer is known to be a complex and evolving tumour site with much of the care management provided by Cancer Nurse Specialist (CNS) outside of traditional outpatient settings. Increased incidences of needing community and home-based care led to service review and redesign, with opportunities to expand nonhospital based management via establishment of Lung Oncology VW. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Richard Sterry, Andrea Worsdale, Leah Taylor, Mark Weatherhead Tags: Clinical Networks and Pathways Source Type: research
34 Predictive value of PD-L1 expression IHC on histology vs. cytology-specimen in non-small cell lung cancer (NSCLC) cohort in Leicester
Checkpoint inhibitors (CPI), especially anti PD-1/anti PD-L1 antibodies, have transformed the treatment paradigm of NSCLC, especially in those without actionable targetable driver mutations. PD-1 is expressed on tumour-infiltrating immune cells and PD-L1 is expressed on antigen presenting cell and tumour cells. PD-L1 expression is detected using immunohistochemistry; multiple assays have been approved as companion diagnostics to a particular CPI. The Blueprint phase II clinical trial highlighted the differing level of sensitivity and reproducibility of each assay, which have important implications for patients ’ eligibil...
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Shradha Bhagani, Anum Sultan, Anupama Vijay, Cathy Richards, Samreen Ahmed Tags: Diagnosis and Staging Source Type: research
35 Validation of published radiomics model to determine if CT parameters predict Programmed Death Ligand 1 expression in Non-Small Cell Lung Cancer
Immune checkpoint inhibitors have revolutionized the NSCLC treatment paradigm. PD-L1 expression by immunohistochemistry is a predictive biomarker but demonstrates spatiotemporal heterogeneity. CT radiomics, where extracted imaging features of the whole tumour, are modelled for predicting PD-L1 expression, may offer a non-invasive method to determine PD-L1 status. However, published models have not been reproduced in an external dataset and the underlying biological association with imaging features is unknown. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Thubeena Manickavasagar, Thubeena Manickavasagar, Caroyln Horst, Robert O'Shea, Daniel Hughes, Eleni Josephides, Daisuke Nonaka, Andre Bille, Eleni Karapanagiotou, Gary Cook, Vicky Goh Tags: Diagnosis and Staging Source Type: research
36 Summary of data for CT-guided percutaneous lung biopsy from West Yorkshire and Harrogate Cancer Alliance in 2021
CT-guided lung biopsy (CTGLB) is a common procedure in diagnosing lung cancer. According to British Thoracic Society (BTS), CTGLB has significantly resulted in reduction of unnecessary surgery. BTS estimated that 64% of patients who had undergone the biopsy had a malignant diagnosis. The most common complication from the procedure is pneumothorax (15%), 6.6% resulting in chest drain insertion. Some other rare complications include haemorrhage (1%), air embolism (0.4%) and death (0.16%). The National Lung Cancer Audit (NLCA) recommends that>90% of patients with stage I and II disease with performance status of 0 to 1 should...
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: LiJi Ng, Stephen Zwolinsky, Georgina Esterbrook, Cheyne Leanne Tags: Diagnosis and Staging Source Type: research
37 PLB Lung Biopsy Audit (Worcestershire Acute Hospitals NHS Trust)
Percutaneous lung biopsy is widely performed by Radiologists using CT guidance. British Thoracic Society (BTS) guidelines recommend standards for UK health services, including for waiting times, diagnostic adequacy and complication rates. This ongoing Audit monitored compliance with guidelines at Worcester acute hospitals NHS Trust (WAHT) over a five-year period. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Muhammad Ovais Fateh, Mark Maddock, Hanif Marty Tags: Diagnosis and Staging Source Type: research
38 Modelling Class Dependencies for Lung Cancer Subtyping from Digitised Pathology Images
This study addresses these challenges by constructing a new multi-label dataset where cancer subtypes and associated patterns are both annotated on slide level. A novel computational model is introduced for linking the cancer subtypes and histological patterns in a weakly-supervised fashion. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: George Batchkala, Mengran Fan, Bin Li, Mark McCole, Cecilia Brambilla, Fergus Gleeson, Jens Rittscher Tags: Diagnosis and Staging Source Type: research
39 A multi-centre analysis of the performance of EBUS-TBNA testing for comprehensive molecular profiling in non-small cell lung cancer (NSCLC)
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an important diagnostic tool in lung cancer. Since 2021, the National Optimal Pathway for Lung Cancer in Wales has mandated reflex testing, using Next Generation Sequencing (NGS) for all stage non-small cell lung cancer in line with ESMO recommendations. The utilisation of NGS technologies in EBUS-TBNA specimens has been questioned, especially relating to the volume of tissue needed for successful DNA and RNA analysis. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Craig Dyer, Kelly Marshall, Robin Ghosal, Rhian Williams Tags: Diagnosis and Staging Source Type: research
40 A Retrospective Performance Audit of the West Yorkshire and Harrogate Cancer Alliance's EBUS-TBNA Service
We present the first performance audit of EBUS-TBNA services by the West Yorkshire and Harrogate Cancer Alliance (WYHCA), against the 2019 National Service Specification1. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Thomas Wilkins, LiJi Ng, Sara Upperton, Stephen Zwolinsky, Georgina Esterbrook, Ali Almeri, Sanjay Kumar, Leanne Cheyne Tags: Diagnosis and Staging Source Type: research
41 Rapid on-site evaluation (ROSE) speeds up the fast investigative lung cancer diagnostic pathway
EBUS-TBNA is a method of acquiring tissue samples from intrathoracic lymph nodes and central intrathoracic tumours in patients suspected of having lung cancer. Rapid On-Site Evaluation (ROSE) denotes assessing tissue samples during EBUS (or bronchoscopy), providing instant feedback on sample adequacy and provisional cytomorphological diagnosis. This supports informed discussion and decision making at Sector multidisciplinary team (MDT), with confirmatory immunohistochemistry being finalised before final treatment. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Andrew Fowell, Kashif Khan Tags: Diagnosis and Staging Source Type: research
