42 Evaluation of a novel simulator for linear and radial EBUS at University College London: The Lung Phantom
Linear endobronchial ultrasound (EBUS) has transformed the standard of care for lung cancer diagnosis and is a common procedure in the United Kingdom. The demand for targeted sampling of lung nodules using radial EBUS is anticipated to increase with the implementation of screening. Despite both procedures having a long and complex learning curve, there is currently no standardised teaching or assessment approach. While simulation is a widely accepted method of procedural training, available simulators are expensive and lack anatomical detail. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Monica Mullin, Efthymios Maneas, Anastasia Stoica, Adrien Desjardins, Ricky Thakrar, Neal Navani Tags: Diagnosis and Staging Source Type: research
43 Evaluation of invasive nodal staging practice in lung cancer
Accurate lung cancer staging is essential for prognostication and treatment planning, with intrathoracic lymph node assessment a key component. NICE recommends sampling enlarged (>10 mm short axis on CT) or PET-positive thoracic nodes, with systematic assessment by EBUS. A Public Health Scotland Quality Performance Indicator states that at least 80% of patients with NSCLC and possible mediastinal spread should undergo mediastinal node sampling, but in 2021 this was only achieved in 68.7% of cases Scotland-wide. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Alexandra Teagle, Fraser Millar, David Dorward, Santiago Giavedoni, Adam Marshall Tags: Diagnosis and Staging Source Type: research
44 Bronchoscopy for peripheral lung lesions in patients deemed unsuitable for transthoracic needle biopsy: experience of introducing cone beam imaging
Distinguishing a benign nodule from an early lung cancer remains an important clinical problem. The current standard of care, CT-biopsy, while accurate is associated with high-rates of complications and limitations of what can be biopsied. This has prompted the development of endoscopic approaches, but multimodal technologies have not shown improvements in diagnostic accuracy, largely due to lack of real-time imaging. Cone-beam CT (CBCT) imaging uses a flat panel detector for cone-shaped x-ray beams that are reconstructed into 3D images. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Matthew Wright, Rosalind Shea, Monica Mullin, Roisin Dunwoody, Ricky Thakrar, Neal Navani Tags: Diagnosis and Staging Source Type: research
45 A Comparison of EBUS Data: What's changed in Five years?
We assessed the diagnostic utility of EBUS procedures during 2018 and 2022. We utilised the NHS Endobronchial Ultrasound Service Specification standards for our audit. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Grace Pink, Grace Pink, Abhimanyu Lal, Muhammad Bilal Niazi, Alison Wills Tags: Diagnosis and Staging Source Type: research
46 Automated Derivation of Diagnostic Criteria for Lung Cancer using Natural Language Processing on Electronic Health Records: A pilot study
The digitisation of healthcare records has generated vast amounts of unstructured free text and similar data, this presents opportunities for improvements in disease diagnosis when traditional clinical coding falls short, such as in the recording of patient symptoms. We have piloted an approach using natural language processing (NLP) to extract clinical coding concepts from free text which are used to automatically form diagnostic criteria for lung cancer from unstructured secondary care data. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Andrew Houston, Sophie Williams, William Ricketts, Charles Gutteridge, Chris Tackaberry, Marcus Simon, John Conibear Tags: Diagnosis and Staging Source Type: research
47 Feasiblity of day case thoracoscopy with indwelling catheter insertion
Local anaesthetic thoracoscopy is a well established diagnostic and therapeutic tool for undiagnosed pleural effusions, with a diagnostic sensitivity of above 95%. Traditionally, patients are admitted afterwards, on average for 3 days. Day case thoracoscopy with concurrent indwelling pleural catheter (IPC) insertion and same day discharge has been adopted in some centres. No randomised trials have been published. Service evaluations thus help to determine safety. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Helen Turnbull, Avinash Aujayeb Tags: Diagnosis and Staging Source Type: research
48 Real world outcomes of a lung cancer genomic tumour advisory board: a single-centre experience in the United Kingdom
The role of the genomic tumour advisory board (GTAB) is to provide expert opinion on the clinical impact of genomic alterations. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Alexius John, Charlotte Milner-Watts, Hazel O'Sullivan,, Nicholas Waldron, Eugenie Younger, Nadza Tokaca, Jaishree Bhosle, Anna Minchom, Michael Davidson, Mary O'Brien,, Suzanne MacMahon, Terri McVeigh, Angela George, Sanjay Popat Tags: Diagnosis and Staging Source Type: research
49 Comparing molecular diagnostic using In-house reflex testing and Next-Generation Sequencing (NGS), A cancer alliance experience in Non-small cell lung cancer (NSCLC)
Genomic testing is standard of care for newly diagnosed NSCLC patients. Gold standard NGS is commissioned but concerns exist around turnaround time (TAT) and failure rate. Rapid turnaround PCR based technology might be a suitable adjunct in delivering a clinical service. In our centre, an inhouse strategy has been developed which is detailed in the methods. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Hassan Heba, Gillian Donald, Riyaz Shah Tags: Diagnosis and Staging Source Type: research
50 Patient Characteristics and Outcomes from a Pulmonary Nodule Surveillance Service
Current guidelines recommend CT surveillance for some patients with indeterminate pulmonary nodules. An accepted risk of surveillance is stage progression of malignant nodules. Although this risk is thought to be small, there is minimal published data that has attempted to quantify this occurrence. Here we present characteristics and outcomes from patients under nodule surveillance. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Sarah Ahmad, Sarah Billingsley, Sadia Anwar, Bobby Bhartia, Alex Brunelli, Seung-Jin Choi, Michael Darby, Annette Johnson, Shishir Karthik, Martyn Kennedy, Phillip Melling, Marco Nardini, Elankumaran Paramasivam, Jonathan Robson, Kirsty Rodger, Matthew Ca Tags: Diagnosis and Staging Source Type: research
51 Percutaneous tissue sampling in thoracic oncology - are core biopsies bigger and better?
Small biopsies are the predominant source of tissue diagnosis in thoracic malignancy. As more tissue is required for expanding range of targets, should core biopsies replace fine-needle aspiration to ensure delivering enough material for diagnosis? (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Hassan Maged, Fahd Irshad Tags: Diagnosis and Staging Source Type: research
52 Patient outcome at rapid access lung cancer clinic
The lung cancer diagnostic pathway comprises multiple investigations with aim of achieving diagnosis or exclusion of lung cancer within 28 days of referral. First investigation is typically CT thorax, followed by “bundle” of investigations for suspected lung cancer. At our institution, our “rapid lung cancer clinic” arranges the initial CT and subsequent investigations. However, cancer pick-up rate, incidental CT findings and subsequent follow-up generated from rapid clinic remains unclear. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Andrew Fowell, Elvina Victor, Joanne Woolley, Phebe Bhaskar, Gemma Lynch, Kashif Khan Tags: Diagnosis and Staging Source Type: research
53 Comparison of molecular testing strategies in non small cell lung cancer: “reflex” vs “hybrid” approaches
While reflex molecular testing of all non-squamous non-small cell lung carcinomas (NSCLC) is advised there is little data examining the proportion of testing that immediately impacts clinical care leading to concerns over wasted resource. Before 2022 our department adopted a “hybrid” pathologist/multi-disciplinary team-led model where reflex testing was undertaken for patients with stage IV disease and fit for systemic treatment. Testing was also requested later in the event of disease relapse/progression. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Carole Manning, Katherine Quiohilag, Anca Oniscu, David Dorward Tags: Diagnosis and Staging Source Type: research
54 A population-based review of early-onset lung cancer patients in Northern Ireland
Early-onset lung cancer ( (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Ashleigh Russell, Dharmesh Valand, Laura McGarry, Megan Ryan, Roisin Connon, Paula Scullin, Lynn Campbell Tags: Diagnosis and Staging Source Type: research
55 Prevention of “on-the-day cancellation” of bronchoscopy procedures to improve waiting time for cancer patients-department based Quality Improvement initiative
On-the-day cancellation of procedures may be inevitable, but can put a significant strain on waiting times for endoscopic procedures. A thorough scrutiny of procedures may help in preventing this and improve service quality. Objective: To determine the frequency and reasons for cancellation of bronchoscopy procedures on the day of appointment, and to develop a robust vetting process to minimize these and improve patient waiting times. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Usman Khalid Tags: Diagnosis and Staging Source Type: research
56 Simultaneous pneumothorax and mesothelioma
The North-East of England has one of the highest incidence and case fatality rates for mesothelioma in the United Kingdom. Northumbria Healthcare NHS Foundation Trust has seen 317 cases from January 2009 till July 2023. Mesothelioma presents very rarely as pneumothorax.1 We performed a review of the local database to ascertain our local incidence. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Leah Taylor, Helen Wallace, Avinash Aujayeb Tags: Mesothelioma Source Type: research
