Journal of Molecular and Cellular Cardiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Preserved cardiac performance and adrenergic response in a rabbit model with decreased ryanodine receptor 2 expression
Ryanodine receptor 2 (RyR2) is an ion channel in the heart responsible for releasing into the cytosol most of the Ca2+ required for contraction. Proper regulation of RyR2 is critical, as highlighted by the association between channel dysfunction and cardiac arrhythmia. Lower RyR2 expression is also observed in some forms of heart disease; however, there is limited information on the impact of this change on excitation-contraction (e-c) coupling, Ca2+-dependent arrhythmias, and cardiac performance. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - April 9, 2022 Category: Cytology Authors: Jingjing Zheng, Holly C. Dooge, Marta P érez-Hernández, Yan-Ting Zhao, Xi Chen, Jonathan J. Hernandez, Carmen R. Valdivia, Julieta Palomeque, Eli Rothenberg, Mario Delmar, Héctor H. Valdivia, Francisco J. Alvarado Source Type: research

Synergistic FRET assays for drug discovery targeting RyR2 channels
A key therapeutic target for heart failure and arrhythmia is the deleterious leak through sarcoplasmic reticulum (SR) ryanodine receptor 2 (RyR2) calcium release channels. We have previously developed methods to detect the pathologically leaky state of RyR2 in adult cardiomyocytes by monitoring RyR2 binding to either calmodulin (CaM) or a biosensor peptide (DPc10). Here, we test whether these complementary binding measurements are effective as high-throughput screening (HTS) assays to discover small molecules that target leaky RyR2. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - April 8, 2022 Category: Cytology Authors: RobynT. Rebbeck, Kenneth S. Ginsburg, Christopher Y. Ko, Anna Fasoli, Katherine Rusch, George F. Cai, Xiaoqiong Dong, David D. Thomas, Donald M. Bers, Razvan L. Cornea Source Type: research

A misdirected conundrum in translational HFpEF research
In 2021, the term “heart failure (HF) with preserved ejection fraction” (HFpEF) garnered more than 900 PubMed citations, which is greater than a 10-fold increase from 2011. Of these>900 peer-reviewed publications published in 2021, more than a third corresponded to commentaries, editorials, reviews, and systematic reviews in HFpEF, in contrast to less than 100 clinical HFpEF studies. Despite the exponential growth in publications, there has been little advances in therapies for HFpEF [1 –3], with only the first positive multinational clinical drug study reported in October 2021 [1]. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - April 8, 2022 Category: Cytology Authors: Mar ía Valero-Muñoz, Flora Sam Tags: Letter to the editor Source Type: research

Improving insights into the heterogeneous HFpEF syndrome through microvascular research
In the past few years, basic, translational and clinical research in heart failure with preserved ejection fraction (HFpEF) has intensified while patient numbers rise [1]. The search for effective treatments parallels the search for a better understanding of the pathophysiological mechanisms driving HFpEF. We address limitations regarding the suggested central role of microvascular dysfunction (MVD) in HFpEF and suggest a translational approach to bridge knowledge gaps therein. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - April 7, 2022 Category: Cytology Authors: Jerremy Weerts, Sanne G.J. Mourmans, Etto Eringa, Vanessa P.M. van Empel Tags: Letter to the editor Source Type: research

Transmural myocardial repair with engineered heart muscle in a rat model of heterotopic heart transplantation – A proof-of-concept study
Engineered heart muscle (EHM) can be implanted epicardially to remuscularize the failing heart. In case of a severely scarred ventricle, excision of scar followed by transmural heart wall replacement may be a more desirable application. Accordingly, we tested the hypothesis that allograft (rat) and xenograft (human) EHM can also be administered as transmural heart wall replacement in a heterotopic, volume-loaded heart transplantation model. We first established a novel rat model model to test surgical transmural left heart wall repair. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - April 4, 2022 Category: Cytology Authors: Ahmad-Fawad Jebran, Malte Tiburcy, Daniel Biermann, Paul Balfanz, Michael Didi é, Bijoy Chandapillai Karikkineth, Friedrich Schöndube, Ingo Kutschka, Wolfram-Hubertus Zimmermann Source Type: research

Cardio-oncology imaging tools at the translational interface
Cardiovascular imaging is an evolving component in the care of cancer patients. With improved survival following prompt cancer treatment, patients are facing increased risks of cardiovascular complications. While currently established imaging modalities are providing useful structural mechanical information, they continue to develop towards increased specificity. New modalities, emerging from basic science and oncology, are being translated, targeting earlier stages of cardiovascular disease. Besides these technical advances, matching an imaging modality with the patients' individual risk level for a specific pathological ...
Source: Journal of Molecular and Cellular Cardiology - April 3, 2022 Category: Cytology Authors: Katarina Yaros, Benay Eksi, Alvin Chandra, Kartik Agusala, Lorenz H. Lehmann, G. Zaha Vlad Source Type: research

Prostaglandin D2 signaling and cardiovascular homeostasis
Cardiovascular diseases are the leading cause of death worldwide. A chronic inflammatory response is a common pathological alteration in diverse cardiovascular diseases. Prostaglandin (PG) D2, a key lipid mediator derived from arachidonic acid metabolism, promotes resolution of inflammation and regulated T cell function through its receptors. Accumulated evidence has shown that dysregulated PGD2 signaling is involved in the pathogenesis of cardiovascular diseases, including atherosclerosis, hypertension, pulmonary hypertension, abdominal aortic aneurysm, and myocardial ischemia. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - March 31, 2022 Category: Cytology Authors: Deping Kong, Ying Yu Source Type: research

Enhanced NCLX-dependent mitochondrial Ca2+ efflux attenuates pathological remodeling in heart failure
Mitochondrial calcium (mCa2+) uptake couples changes in cardiomyocyte energetic demand to mitochondrial ATP production. However, excessive mCa2+ uptake triggers permeability transition and necrosis. Despite these established roles during acute stress, the involvement of mCa2+ signaling in cardiac adaptations to chronic stress remains poorly defined. Changes in NCLX expression are reported in heart failure (HF) patients and models of cardiac hypertrophy. Therefore, we hypothesized that altered mCa2+ homeostasis contributes to the hypertrophic remodeling of the myocardium that occurs upon a sustained increase in cardiac work...
Source: Journal of Molecular and Cellular Cardiology - March 28, 2022 Category: Cytology Authors: Joanne F. Garbincius, Timothy S. Luongo, Pooja Jadiya, Alycia N. Hildebrand, Devin W. Kolmetzky, Adam S. Mangold, Rajika Roy, Jessica Ibetti, Mary Nwokedi, Walter J. Koch, John W. Elrod Source Type: research

Genetics of cancer therapy-associated cardiotoxicity
As the number of cancer survivors has increased significantly over the last decades due to aging of population and development of effective cancer therapies, side effects from cancer therapies have been increasingly recognized. High-dose anthracyclines, immunotherapies, and concurrent radiation, as well as traditional cardiovascular risk factors such as smoking, hypertension, diabetes, hyperlipidemia, and obesity increase risks for unintended cardiovascular toxicity. However, these factors do not fully explain why only a subset of patients develop adverse cardiovascular sequelae from cancer therapies. (Source: Journal of M...
Source: Journal of Molecular and Cellular Cardiology - March 28, 2022 Category: Cytology Authors: Yuri Kim, Jonathan G. Seidman, Christine E. Seidman Source Type: research

Coronary vessel formation in development and regeneration: origins and mechanisms
Neovascularization of the ischemic myocardium following infarction is vital for the survival of cardiomyocytes and prevention of heart failure. However, the intrinsic revascularization following ischemic injury in the heart is inadequate to restore blood flow to the infarcted myocardium. A comprehensive understanding of how coronary vasculature is constructed and what developmental pathways might be reactivated after infarction is beneficial to develop effective strategies for heart revascularization. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - March 27, 2022 Category: Cytology Authors: Xueying Tian, Bin Zhou Source Type: research

Heart failure with preserved ejection fraction: An age-related condition
Heart failure with preserved ejection fraction (HFpEF), which affects at least half of all heart failure patients, is an ominous disease associated with poor quality of life, premature mortality and a major socioeconomic burden [1]. Since evidence-based therapies for HFpEF remain limited, HFpEF is largely considered one of the most pressing unmet needs in cardiology. Incomplete understanding of the pathophysiological mechanisms driving HFpEF may explain the lack of specific therapies that effectively reduce HFpEF-related mortality. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - March 24, 2022 Category: Cytology Authors: Mahmoud Abdellatif, Guido Kroemer Tags: Letter to the editor Source Type: research

Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19
Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target.ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - March 23, 2022 Category: Cytology Authors: George R. Abraham, Rhoda E. Kuc, Magnus Althage, Peter J. Greasley, Philip Ambery, Janet J. Maguire, Ian B. Wilkinson, Stephen P. Hoole, Joseph Cheriyan, Anthony P. Davenport Source Type: research

Cardiac mechanisms of the beneficial effects of SGLT2 inhibitors in heart failure: Evidence for potential off-target effects
Sodium glucose cotransporter 2 inhibitors (SGLT2i) constitute a promising drug treatment for heart failure patients with either preserved or reduced ejection fraction. Whereas SGLT2i were originally developed to target SGLT2 in the kidney to facilitate glucosuria in diabetic patients, it is becoming increasingly clear that these drugs also have important effects outside of the kidney. In this review we summarize the literature on cardiac effects of SGLT2i, focussing on pro-inflammatory and oxidative stress processes, ion transport mechanisms controlling sodium and calcium homeostasis and metabolic/mitochondrial pathways. (...
Source: Journal of Molecular and Cellular Cardiology - March 21, 2022 Category: Cytology Authors: Jason R.B. Dyck, Samuel Sossalla, Nazha Hamdani, Ruben Coronel, Nina C. Weber, Peter E. Light, Coert J. Zuurbier Tags: Review article Source Type: research

Inhibition of sphingomyelinase attenuates diet – Induced increases in aortic stiffness
Sphingomyelinases ensure ceramide production and play an integral role in cell turnover, inward budding of vesicles and outward release of exosomes. Recent data indicate a unique role for neutral sphingomyelinase (nSMase) in the control of ceramide-dependent exosome release and inflammatory pathways. Further, while inhibition of nSMase in vascular tissue attenuates the progression of atherosclerosis, little is known regarding its role on metabolic signaling and arterial vasomotor function. Accordingly, we hypothesized that nSMase inhibition with GW4869, would attenuate Western diet (WD) - induced increases in aortic stiffn...
Source: Journal of Molecular and Cellular Cardiology - March 21, 2022 Category: Cytology Authors: Javad Habibi, Vincent G. DeMarco, Jack L. Hulse, Melvin R. Hayden, Adam Whaley-Connell, Michael A. Hill, James R. Sowers, Guanghong Jia Source Type: research

A ‘Swine Time’ for HFpEF: Multiple animal models for a myriad of clinical phenotypes
“Check yourself before you wreck yourself” - sage words for any researcher using animal models to study heart failure with preserved ejection fraction (HFpEF). Those who have conducted animal studies examining HFpEF are likely familiar with “Jekyll and Hyde” responses spanning “that totall y mimics HFpEF disease pathology” to “that in no way, shape, or form reflects HFpEF”. This extreme commentary has diminished, as a heterogenous collection of clinical risk factors has uncovered a diverse array of HFpEF phenotypes. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - March 19, 2022 Category: Cytology Authors: Craig A. Emter Tags: Letter to the editor Source Type: research