Journal of Molecular and Cellular Cardiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Role and therapeutic potential of gelsolin in atherosclerosis
Atherosclerosis is the major pathophysiological basis of a variety of cardiovascular diseases and has been recognized as a lipid-driven chronic inflammatory disease. Gelsolin (GSN) is a member of the GSN family. The main function of GSN is to cut and seal actin filaments to regulate the cytoskeleton and participate in a variety of biological functions, such as cell movement, morphological changes, metabolism, apoptosis and phagocytosis. Recently, more and more evidences have demonstrated that GSN is Closely related to atherosclerosis, involving lipid metabolism, inflammation, cell proliferation, migration and thrombosis. (...
Source: Journal of Molecular and Cellular Cardiology - March 24, 2023 Category: Cytology Authors: Qiang Zhang, Xiao-HuiWen, Shi-Lin Tang, Zhen-Wang Zhao, Chao-Ke Tang Source Type: research

Optogenetic termination of atrial tachyarrhythmias by brief pulsed light stimulation
The most efficient way to acutely restore sinus rhythm from atrial fibrillation (AF) is electrical cardioversion, which is painful without adequate sedation. Recent studies in various experimental models have indicated that optogenetic termination of AF using light-gated ion channels may provide a myocardium-specific and potentially painless alternative future therapy. However, its underlying mechanism(s) remain(s) incompletely understood. As brief pulsed light stimulation, even without global illumination, can achieve optogenetic AF termination, besides direct conduction block also modulation of action potential (AP) prop...
Source: Journal of Molecular and Cellular Cardiology - March 23, 2023 Category: Cytology Authors: Motoki Nakao, Masaya Watanabe, Lucile Miquerol, Hiroyuki Natsui, Takuya Koizumi, Takahide Kadosaka, Taro Koya, Hikaru Hagiwara, Rui Kamada, Taro Temma, Antoine A.F. de Vries, Toshihisa Anzai Source Type: research

Direct cardiac reprogramming: A new technology for cardiac repair
Cardiovascular disease is one of the leading causes of morbidity and mortality worldwide, with myocardial infarctions being amongst the deadliest manifestations. Reduced blood flow to the heart can result in the death of cardiac tissue, leaving affected patients susceptible to further complications and recurrent disease. Further, contemporary management typically involves a pharmacopeia to manage the metabolic conditions contributing to atherosclerotic and hypertensive heart disease, rather than regeneration of the damaged myocardium. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - March 23, 2023 Category: Cytology Authors: Paige E. Brlecic, Clark A. Bonham, Todd K. Rosengart, Megumi Mathison Tags: Review article Source Type: research

Cellular reprogramming of fibroblasts in heart regeneration
Myocardial infarction causes the loss of cardiomyocytes and the formation of cardiac fibrosis due to the activation of cardiac fibroblasts, leading to cardiac dysfunction and heart failure. Unfortunately, current therapeutic interventions can only slow the disease progression. Furthermore, they cannot fully restore cardiac function, likely because the adult human heart lacks sufficient capacity to regenerate cardiomyocytes. Therefore, intensive efforts have focused on developing therapeutics to regenerate the damaged heart. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - March 23, 2023 Category: Cytology Authors: Congwu Chi, Kunhua Song Tags: Review article Source Type: research

RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure
Dantrolene binds to the Leu601-Cys620 region of the N-terminal domain of cardiac ryanodine receptor (RyR2), which corresponds to the Leu590-Cys609 region of the skeletal ryanodine receptor, and suppresses diastolic Ca2+ leakage through RyR2. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - March 22, 2023 Category: Cytology Authors: Shohei Fujii, Shigeki Kobayashi, Yaowei Chang, Junya Nawata, Ryosuke Yoshitomi, Shinji Tanaka, Michiaki Kohno, Yoshihide Nakamura, Hironori Ishiguchi, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Takayuki Okamura, Takeshi Yamamoto, Mas Source Type: research

Retraction notice to “Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: Role of insulin signaling and ER stress” [Journal of Molecular and Cellular Cardiology 44/6 (2008) 992–1001]
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - March 21, 2023 Category: Cytology Authors: Shi-Yan Li, Jun Ren Source Type: research

Retraction notice to “Akt2 knockout alleviates prolonged caloric restriction-induced change in cardiac contractile function through regulation of autophagy” [Journal of Molecular and Cellular Cardiology 71C (2014) 81–91]
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - March 21, 2023 Category: Cytology Authors: Yingmei Zhang, Xuefeng Han, Nan Hu, Anna F. Huff, Feng Gao, Jun Ren Source Type: research

Cardiomyocyte hyperplasia and immaturity but not hypertrophy are characteristic features of patients with RASopathies
RASopathies are caused by mutations in genes that alter the MAP kinase pathway and are marked by several malformations with cardiovascular disorders as the predominant cause of mortality. Mechanistic insights in the underlying pathogenesis in affected cardiac tissue are rare. The aim of the study was to assess the impact of RASopathy causing mutations on the human heart. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - March 20, 2023 Category: Cytology Authors: J örg-Detlef Drenckhahn, Luka Nicin, Sara Akhouaji, Svenja Krück, Anna Eva Blank, Anne Schänzer, Uygar Yörüker, Christian Jux, Lukas Tombor, Wesley Abplanalp, David John, Andreas M. Zeiher, Stefanie Dimmeler, Stefan Rupp Source Type: research

Development of direct cardiac reprogramming for clinical applications
The incidence of cardiovascular diseases is increasing worldwide, and cardiac regenerative therapy has great potential as a new treatment strategy, especially for ischemic heart disease. Direct cardiac reprogramming is a promising new cardiac regenerative therapy that uses defined factors to induce transdifferentiation of endogenous cardiac fibroblasts (CFs) into induced cardiomyocyte-like cells (iCMs). In vivo reprogramming is expected to restore lost cardiac function without necessitating cardiac transplantation by converting endogenous CFs that exist abundantly in cardiac tissues directly into iCMs. (Source: Journal of ...
Source: Journal of Molecular and Cellular Cardiology - March 12, 2023 Category: Cytology Authors: Yu Yamada, Taketaro Sadahiro, Masaki Ieda Tags: Review article Source Type: research

The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants
Genetic testing for inherited arrhythmias and discriminating pathogenic or benign variants from variants of unknown significance (VUS) is essential for gene-based medicine. KCNQ1 is a causative gene of type 1 long QT syndrome (LQTS), and approximately 30% of the variants found in type 1 LQTS are classified as VUS. We studied the role of zebrafish cardiac arrhythmia model in determining the clinical significance of KCNQ1 variants. We generated homozygous kcnq1 deletion zebrafish (kcnq1del/del) using the CRISPR/Cas9 and expressed human Kv7.1/MinK channels in kcnq1del/del embryos. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - March 7, 2023 Category: Cytology Authors: Shihe Cui, Kenshi Hayashi, Isao Kobayashi, Kazuyoshi Hosomichi, Akihiro Nomura, Ryota Teramoto, Keisuke Usuda, Hirofumi Okada, Yaowen Deng, Jingjing Kobayashi-Sun, Tetsuo Nishikawa, Hiroshi Furusho, Takekatsu Saito, Hiroaki Hirase, Kunio Ohta, Manabu Fuji Source Type: research

Caveolin-3 and Caveolae regulate ventricular repolarization
Flask-shaped invaginations of the cardiomyocyte sarcolemma called caveolae require the structural protein caveolin-3 (Cav-3) and host a variety of ion channels, transporters, and signaling molecules. Reduced Cav-3 expression has been reported in models of heart failure, and variants in CAV3 have been associated with the inherited long-QT arrhythmia syndrome. Yet, it remains unclear whether alterations in Cav-3 levels alone are sufficient to drive aberrant repolarization and increased arrhythmia risk. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - February 24, 2023 Category: Cytology Authors: Yogananda S. Markandeya, Zachery R. Gregorich, Li Feng, Vignesh Ramchandran, Thomas O' Hara, Ravi Vaidyanathan, Catherine Mansfield, Alexis M. Keefe, Carl J. Beglinger, Jabe M. Best, Matthew M. Kalscheur, Martin R. Lea, Timothy A. Hacker, Julia Gorelik, N Source Type: research

Drp1/p53 interaction mediates p53 mitochondrial localization and dysfunction in septic cardiomyopathy
Previous studies have implicated p53-dependent mitochondrial dysfunction in sepsis induced end organ injury, including sepsis-induced myocardial dysfunction (SIMD). However, the mechanisms behind p53 localization to the mitochondria have not been well established. Dynamin-related protein 1 (Drp1), a mediator of mitochondrial fission, may play a role in p53 mitochondrial localization. Here we examined the role of Drp1/p53 interaction in SIMD using in vitro and murine models of sepsis. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - February 23, 2023 Category: Cytology Authors: Riddhita Mukherjee, Laura H. Tetri, Sin-Jin Li, Giovanni Fajardo, Nicolai P. Ostberg, Kaleb B. Tsegay, Kanika Gera, Timothy T. Cornell, Daniel Bernstein, Daria Mochly-Rosen, Bereketeab Haileselassie Source Type: research

The longevity protein p66Shc is required for neonatal heart regeneration
In this study, we found that p66Shc deficiency decreased neonatal mouse cardiomyocyte (CM) proliferation and impeded neonatal heart regeneration after apical resection injury. RNA sequencing and functional verification demonstrated that p66Shc regulated CM proliferation by activating β-catenin signaling. These findings reveal the critical role of p66Shc in neonatal heart regeneration and provide new insights into senescence signaling in heart regeneration. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - February 22, 2023 Category: Cytology Authors: Chengzhen Huang, Tong Ding, Yuan Zhang, Xunkai Li, Xin Sun, Shuangjie Lv, Yanyan Hao, Lina Bai, Ning Liu, Yifan Xie, Houzao Chen, Yu Nie Source Type: research

Unlocking cardiomyocyte renewal potential for myocardial regeneration therapy
Cardiovascular disease remains the leading cause of mortality worldwide. Cardiomyocytes are irreversibly lost due to cardiac ischemia secondary to disease. This leads to increased cardiac fibrosis, poor contractility, cardiac hypertrophy, and subsequent life-threatening heart failure. Adult mammalian hearts exhibit notoriously low regenerative potential, further compounding the calamities described above. Neonatal mammalian hearts, on the other hand, display robust regenerative capacities. Lower vertebrates such as zebrafish and salamanders retain the ability to replenish lost cardiomyocytes throughout life. (Source: Journ...
Source: Journal of Molecular and Cellular Cardiology - February 17, 2023 Category: Cytology Authors: Melod Mehdipour, Sangsoon Park, Guo N. Huang Tags: Review article Source Type: research

Targeting immunoregulation for cardiac regeneration
Inducing endogenous cardiomyocyte proliferation and heart regeneration is a promising strategy to treat ischemic heart failure. The immune response has recently been considered critical in cardiac regeneration. Thus, targeting the immune response is a potent strategy to improve cardiac regeneration and repair after myocardial infarction. Here we reviewed the characteristics of the relationship between the postinjury immune response and heart regenerative capacity and summarized the latest studies focusing on inflammation and heart regeneration to identify potent targets of the immune response and strategies in the immune r...
Source: Journal of Molecular and Cellular Cardiology - February 16, 2023 Category: Cytology Authors: Ruopu Li, Chenying Xiang, Yixun Li, Yu Nie Tags: Review article Source Type: research