Journal of Molecular and Cellular Cardiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The role of autophagy in death of cardiomyocytes
Autophagy mediates cellular quality control mechanisms and energy homeostasis through lysosomal degradation. Autophagy is typically viewed as an adaptive process that allows cells to survive against stress, such as nutrient deprivation and hypoxia. However, autophagy also mediates cell death during development and in response to stress. Cell death accompanied by autophagy activation and accumulation of autophagosomes has been classified as type II programmed cell death. Compared to the wealth of knowledge regarding the adaptive role of autophagy, however, the molecular mechanisms through which autophagy induces cell death ...
Source: Journal of Molecular and Cellular Cardiology - December 14, 2021 Category: Cytology Authors: Shohei Ikeda, Daniela Zablocki, Junichi Sadoshima Tags: Review article Source Type: research

Hallmarks of exercised heart
The benefits of exercise in humans on the heart have been well recognized for many years. Long-term endurance exercise training can induce physiologic cardiac hypertrophy with normal or enhanced heart function, and provide protective benefits in preventing heart failure. The heart-specific responses that occur during exercise are complex and highly variable. This review mainly focuses on the current understanding of the structural and functional cardiac adaptations to exercise as well as molecular pathways and signaling proteins responsible for these changes. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - December 13, 2021 Category: Cytology Authors: Yan Qiu, Xue Pan, Yiwen Chen, Junjie Xiao Tags: Review article Source Type: research

Corrigendum to “Zhang Y, Han X, Hu N, Huff AF, Gao F, Ren J. Akt2 knockout alleviates prolonged caloric restriction-induced change in cardiac contractile function through regulation of autophagy. [J Mol Cell Cardiol. 2014 Jun; 71:81–91. PMID: 24368095]
The authors of the above-mentioned paper noticed an error in Fig. 6C as reported. The loading sequence of LC3B and the corresponding loading control GAPDH did not follow the sequence of bar graph. The LC3B gel band was thus spliced together (although from the same membrane) to accommodate the loading sequence of bar graph. We failed to insert vertical lines between groups to indicate the non-continuous nature of these gels. The original GAPDH loading for LC3B was not used due to the complicated splicing procedure. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - December 6, 2021 Category: Cytology Authors: Yingmei Zhang, Xuefeng Han, Nan Hu, Anna F. Huff, Feng Gao, Jun Ren Tags: Corrigendum Source Type: research

Corrigendum to “Lethal giant larvae 1 inhibits smooth muscle calcification via high mobility group box 1” [J Mol Cell Cardiol. 2020;142:39–52]
The authors regret that GAPDH strip in Fig. 5A was used by mistake, which was made unintentionally. (See Fig. 5.) (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - December 3, 2021 Category: Cytology Authors: Tianran Zhang, Guangqing Cao, Xiao Meng, Changhan Ouyang, Jiangang Gao, Yuanyuan Sun, Jiliang Wu, Qing Min, Cheng Zhang, Wencheng Zhang Tags: Corrigendum Source Type: research

Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications
The global propagation of SARS-CoV-2 leads to an unprecedented public health emergency. Despite that the lungs are the primary organ targeted by COVID-19, systemic endothelial inflammation and dysfunction is observed particularly in patients with severe COVID-19, manifested by elevated endothelial injury markers, endotheliitis, and coagulopathy. Here, we review the clinical characteristics of COVID-19 associated endothelial dysfunction; and the likely pathological mechanisms underlying the disease including direct cell entry or indirect immune overreactions after SARS-CoV-2 infection. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - November 23, 2021 Category: Cytology Authors: Zhangjing Ma, Kevin Y. Yang, Yu Huang, Kathy O. Lui Source Type: research