Preserved cardiac performance and adrenergic response in a rabbit model with decreased ryanodine receptor 2 expression

Ryanodine receptor 2 (RyR2) is an ion channel in the heart responsible for releasing into the cytosol most of the Ca2+ required for contraction. Proper regulation of RyR2 is critical, as highlighted by the association between channel dysfunction and cardiac arrhythmia. Lower RyR2 expression is also observed in some forms of heart disease; however, there is limited information on the impact of this change on excitation-contraction (e-c) coupling, Ca2+-dependent arrhythmias, and cardiac performance.

Source: Journal of Molecular and Cellular Cardiology - April 9, 2022 Category: Cytology Authors: Jingjing Zheng, Holly C. Dooge, Marta P érez-Hernández, Yan-Ting Zhao, Xi Chen, Jonathan J. Hernandez, Carmen R. Valdivia, Julieta Palomeque, Eli Rothenberg, Mario Delmar, Héctor H. Valdivia, Francisco J. Alvarado Source Type: research