Journal of Lower Genital Tract Disease This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Adult Vulvar Lichen Sclerosus: Can Experts Agree on the Assessment of Disease Severity?
Conclusions Global experts were unable to agree on any signs, architectural changes, or an overall global impression to assess vulvar LS disease severity based on analysis of vulvar photographs. Standardized descriptions regarding what constitutes mild, moderate, and severe signs and anatomical changes are required before further scale development can occur. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - June 23, 2020 Category: OBGYN Tags: Vulvovaginal Derm Source Type: research

Features of the Vaginal and Vestibular Microbioma in Patients With Vestibulodynia: A Case-Control Study
Objective Our objective was to determine the role of vaginal and/or vestibular microbiota disturbance as an associated factor of symptom characteristic of provoked vestibulodynia (PVD). Study Design In an observational case-control study, the bacterial microbiomes in the vagina and vestibule from 20 women with PVD and 18 healthy controls were compared using a 16S rRNA gene-based molecular analysis. Clinical data were recorded through a 0- to 10-point visual analog scale related to dyspareunia and vulvovaginal pain/burning. Results Comparative assessment of the bacterial taxa (cutoff ≥15%) revealed 105 genera in t...
Source: Journal of Lower Genital Tract Disease - June 23, 2020 Category: OBGYN Tags: Vaginal Source Type: research

Oral Intake of Lactobacilli Can Be Helpful in Symptomatic Bacterial Vaginosis: A Randomized Clinical Study
Conclusions Oral intake of L. crispatus LMG S-29995, L. brevis, and L. acidophilus can significantly decrease percent of recurrences of BV in recently treated women and prolong time to recurrence of the disease. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - June 23, 2020 Category: OBGYN Tags: Vaginal Source Type: research

Five Percent Monolaurin Vaginal Gel for the Treatment of Bacterial Vaginosis: A Randomized Placebo-Controlled Trial
Conclusions Monolaurin was no more clinically or microbiologically effective than placebo in curing BV. Future research should explore whether monolaurin may be used to increase Lactobacilli species. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - June 23, 2020 Category: OBGYN Tags: Vaginal Source Type: research

Management of Malignant Vulval Melanoma: A Retrospective Case Series and Review of the Literature
Conclusions This retrospective multicenter study highlights the high recurrence rate and poor prognosis of vulval melanoma. Lymph node surgery did not make any difference to recurrence-free survival or overall survival. The presence of microsatellites was associated with a statistically increased risk of death. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - June 23, 2020 Category: OBGYN Tags: Other Neoplasia Source Type: research

Predictive Value of an Alternative Strategy for Measuring Depth and Size of Stage 1 Vulvar Squamous Cell Carcinoma
Conclusions Patients downstaged using alternative measurement techniques lacked nodal disease/recurrence; one-third of those with nodal sampling experienced postoperative morbidity. Our data suggest that the use of alternative depth and cumulative extent of invasion could safely allow some conventional stage IB vulvar SCC patients to avoid groin surgery, thereby reducing treatment-related morbidity. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - June 23, 2020 Category: OBGYN Tags: Other Neoplasia Source Type: research

Cervical Stratified Mucin-Producing Intraepithelial Lesion: A Systematic Review of Diagnosis and Management
Conclusions Stratified mucin-producing intraepithelial lesion is a rare lesion with a paucity of research on necessary cytology and IHC stains for diagnosis, but p16 and Ki-67 IHC stains can be performed to rule out benign lesions. The lesion is associated with high risk of concurrent high-grade squamous intraepithelial lesion, adenocarcinoma in situ, and invasive carcinoma, but studies on the risk of pursuing fertility-preserving management are needed. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - June 23, 2020 Category: OBGYN Tags: Management Source Type: research

Risk of Recurrence After Treatment for Cervical Intraepithelial Neoplasia 3 and Adenocarcinoma In Situ of the Cervix: Recurrence of CIN 3 and AIS of Cervix
Conclusions Recurrence risk of CIN 3 and AIS is related to age, histology, and posttreatment cytology, which should assist with discharge planning from colposcopy. Definitive treatment with hysterectomy should be considered in women older than 45 years with additional risk factors for recurrence. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - June 23, 2020 Category: OBGYN Tags: Management Source Type: research

Risk of High-Grade Histopathology Diagnosed by Cervical Conization in Endocervical Curettage Cervical Intraepithelial Neoplasia 1: A Case-Control Study
Objective The aim of the study was to estimate risks of cervical intraepithelial neoplasia 2+ (CIN 2+) on loop electrosurgical excisional procedure (LEEP) specimens with the diagnosis of endocervical curettage (ECC) CIN 1 compared with biopsy CIN 1. Materials and Methods We performed a retrospective computer-based search for subjects enrolled in the Obstetrics and Gynecology Hospital of Fudan University. The case group comprised women with an ECC CIN 1 (ECC results of CIN 1 with colposcopy-directed biopsy results ≤CIN 1), and the control group comprised women with a biopsy CIN 1 (colposcopy-directed biopsy results o...
Source: Journal of Lower Genital Tract Disease - June 23, 2020 Category: OBGYN Tags: Management Source Type: research

Evaluation of Liquid Versus Dry Specimen Transport With a Newly Validated Isothermal Amplification High-Risk Human Papillomavirus Assay
Conclusions Endocervical specimens transported dry have similar proportion of positive HR-HPV tests as those transported in liquid media. Dry brush transport of endocervical samples paired with the special characteristics of AmpFire HR-HPV may become an important addition to population based cervical cancer screening. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - June 23, 2020 Category: OBGYN Tags: Screening Source Type: research

Retrospective 15-Year Review of Anal Cytology Screening in Women at Mayo Clinic Rochester, Minnesota
Conclusions High-risk women should be screened on a periodic basis for anal cancer. Anal cytology is one possible modality that can be used. Further insight into AIN progression, regression, recurrence, and outcome after treatment will help direct future screening recommendations. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - June 23, 2020 Category: OBGYN Tags: Screening Source Type: research

P16/Ki-67 Immunostaining in the Triage of Postmenopausal Women With Low-Grade Cytology Results
Conclusions Dual p16/Ki-67 immunostaining is a useful additional method in postmenopausal patients with low-grade cytology. Considering the high specificity and negative predictive value in our study, we believe that it could be helpful in avoiding unnecessary referrals to colposcopy and thus reduce the cost of the program. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - June 23, 2020 Category: OBGYN Tags: Screening Source Type: research

Health Care for Transgender Men: What Is Missing in OB/GYN Care?
Conclusions It is important for TGM who have a vagina, cervix, and/or uterus to have routine gynecological screenings. However, the lack of gender inclusive care in OB/GYN clinics presents a barrier for many TGM and the recommendations emphasized in this commentary will increase sensitivity for the TGM patient population and decrease their marginalization in health care settings. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2020 Category: OBGYN Tags: Commentary Source Type: research

Vestibulovaginal Sclerosis in a Transgender Man on Testosterone
No abstract available (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2020 Category: OBGYN Tags: Vulvovaginal Disease Source Type: research

Fractionated CO2 Laser as Therapy in Recalcitrant Lichen Sclerosus
Conclusions The fractionated CO2 laser may be a helpful approach for managing LS that is unresponsive to traditional treatment options. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2020 Category: OBGYN Tags: Vulvovaginal Disease Source Type: research