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A Pilot Proteomic Study of Vestibular Fluid From Patients With Vulvodynia
Conclusions The findings of this pilot study demonstrate a set of vestibule mucosa proteins that differ significantly—either increasing or decreasing—in vulvodynia patients compared with controls, and several others that exhibited greater than 1.5-fold change but did not reach statistical significance. This study constitutes a proof-of-principle that an open, unbiased proteomic approach can identify molecular participants in vulvodynia, some of which had not been identified to date by hypothesis-driven studies. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: Vulvar Pain and Vulvodynia Source Type: research

Learning on the Go: Assessing Knowledge Gained From Medical Podcasts Created for Vulvovaginal Disease Education
Objective The aim of the study was to evaluate the effectiveness of “The Vulva Diaries” podcast as a novel learning tool for vulvovaginal disease education. Materials and Methods Medical students and residents were invited to participate in the study using social media advertisements. Online pretests and posttests, one based on a podcast episode regarding genital herpes and the other on lichen sclerosus, were used to assess changes in knowledge level pre– and post–podcast listening in medical students and residents respectively. A second posttest was sent out 2 weeks after the first to assess knowledge r...
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: Non-HPV Associated Vulvovaginal Disease Source Type: research

Nonsquamous Lesions of the Vulvar Skin and Subcutaneous Tissue: A Review (Part 2)
Conclusions Clinicopathological features of nonsquamous lesions of the vulvar skin and subcutaneous tissue as categorized by the updated World Health Organization classification are presented. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: Non-HPV Associated Vulvovaginal Disease Source Type: research

Metastatic Neoplasms to the Vulva—A Review
Conclusions It is important to consider biopsy for appropriate histologic and immunohistochemical studies, as well as consider patient history to establish the primary site of metastatic lesions to the vulva, allowing optimal therapy. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: Non-HPV Associated Vulvovaginal Disease Source Type: research

Risk Factor and Treatment of Vaginal Intraepithelial Neoplasia After Hysterectomy for Cervical Intraepithelial Neoplasia
Conclusions Patients older than 50 years who underwent hysterectomy for the treatment of CIN might be highly at risk of VaIN1+. Laser vaporization is the only independent prognostic factor that might prevent the second VaIN1+ recurrence. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: HPV Associated Vulvovaginal Disease Source Type: research

A Systematic Review of Risk Factors for Development, Recurrence, and Progression of Vulvar Intraepithelial Neoplasia
Conclusions The current body of evidence consists primarily of small retrospective observational studies. Well-designed retrospective case-control series and/or prospective observational studies are urgently needed. Ideally, future studies will collect standardized data regarding associated risk factors and stratify women with VIN based on HPV and TP53 status. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: HPV Associated Vulvovaginal Disease Source Type: research

Changes in Cervical Cytology Results and Human Papillomavirus Types Among Persons Screened for Cervical Cancer, 2007 and 2015–2017
Conclusions Prevalence of vaccine-targeted high-risk HPV types 16/18 was dramatically lower in 2015–2017 than 2007 across all cytology result groups while prevalence of other high-risk HPV types was mainly stable, supporting vaccine impact with no evidence of type replacement. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: HPV Associated Cervical Disease Source Type: research

Contribution of Etiologic Cofactors to CIN3+ Risk Among Women With Human Papillomavirus–Positive Screening Test Results
Conclusions In our study at the Kaiser Permanente Northern California, the risk of CIN 3+ was determined mainly by HPV risk group and cytology results, with other cofactors having limited impact in adjusted analyses. This supports the use of HPV and cytology results in risk-based management guidelines. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: HPV Associated Cervical Disease Source Type: research

Cervical Intraepithelial Neoplasia 3 (Cervical Intraepithelial Neoplasia 3/High-Grade Squamous Intraepithelial Lesion) in Human Papillomavirus–Vaccinated Women—Results From a Tertiary Referral Center
Conclusions It is important to implement vaccination recommendations and administer HPV vaccination as early as possible in HPV-naive individuals. Because not all HR-HPV types are covered by the available HPV vaccines, other types may still cause CIN 3/high-grade squamous intraepithelial lesion. This requires further screening after vaccination, especially in women who were previously vaccinated with the bivalent or the quadrivalent HPV vaccine. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: HPV Associated Cervical Disease Source Type: research

Prognosis of Human Papillomavirus–Negative Compared to Human Papillomavirus–Positive Cervical Cancer
Objectives The aims of the study were to evaluate the prevalence and prognosis of human papillomavirus (HPV)-negative cervical cancer (CC) and to compare these to data for HPV-positive CC. Materials and Methods This retrospective cohort study compared between HPV-negative CC and HPV-positive CC patients. Primary end points were disease-free survival and overall survival. Secondary end points were demographic and clinical variables including histological diagnosis, stage, and treatment. Results Of 233 women with CC, 18 (8%) tested HPV-negative. During a median follow-up of 45 months, 33 (14%) recurrences a...
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: HPV Associated Cervical Disease Source Type: research

Cervical Cancer Among Women With HIV in South Carolina During the Era of Effective Antiretroviral Therapy
Conclusions Women with HIV were younger at diagnosis than HIV-negative women, but they were no more likely to die from or have more advanced cervical cancer. Women with HIV were not more likely to develop cervical cancer before the age of 21 years and earlier screening is likely unnecessary. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: HPV Associated Cervical Disease Source Type: research

A Tribute to Edward J. Wilkinson, MD
No abstract available (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: In Memoriam Source Type: research

The ASCCP President's Message
No abstract available (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: ASCCP President's Message Source Type: research

Inauguration Editorial
No abstract available (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - April 1, 2022 Category: OBGYN Tags: Editor's Message Source Type: research

The Vaginal Microbiome: V. Therapeutic Modalities of Vaginal Microbiome Engineering and Research Challenges
Conclusions Microbiome research has grown dramatically in recent years, motivated by innovations in technology and decrease in analysis costs. This research has yielded huge insight into the nature of microbial communities, their interactions, and effects with their hosts and other microbes. Further understanding of the bacterial, fungal, phage, and viral microbiomes in combination with host genetics, immunologic status, and environmental factors is needed to better understand and provide personalized medical diagnostics and interventions to improve women's health. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - December 23, 2021 Category: OBGYN Tags: Special Section—The Vaginal Microbiome Source Type: research