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Pharmacotherapy Prescriptions for Relapse Prevention of Psychotic Depression After Electroconvulsive Therapy
Conclusions The combination of an antidepressant plus an antipsychotic was the most commonly prescribed regimen at the completion of ECT for relapse prevention in patients with psychotic depression acutely treated with ECT. Although this report offers a view of the clinical practice of 4 academic medical centers, it also points to the need of randomized controlled trials on continuation pharmacotherapy after treatment of psychotic depression with ECT. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Brief Reports Source Type: research

Effects of Oral Administration of Alprazolam and Lorazepam as Hypnotics on Cardiovascular Parameters in Hypertensive Patients
Background Previous studies have suggested that evening intake of benzodiazepine affects blood pressure (BP) and/or heart rate (HR) in healthy and hypertensive subjects. The aim of this study was to compare the effect of chronic oral administration of alprazolam and lorazepam as hypnotics on ambulatory BP and HR in patients with mild hypertension. Methods Consecutive outpatients of both sexes with newly diagnosed, never-treated mild hypertension were randomized, after a 4-week placebo run-in period, to receive alprazolam 0.5 mg plus placebo, lorazepam 1 mg plus placebo, or placebo plus placebo for 2 weeks in 3 c...
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Brief Reports Source Type: research

High-Dose Fluvoxamine Augmentation to Clozapine in Treatment-Resistant Psychosis
Conclusions Although high variability of responses and adverse effects were observed during fluvoxamine augmentation to clozapine, this strategy was successful in increasing clozapine serum levels. Through fluvoxamine's serotonergic effects, this strategy may confer benefit to residual negative, obsessive, and anxiety symptoms. Limitations of this case series include the retrospective nature, absence of controls, diversity of diagnoses, multiple interventions in each patient, and lack of masked raters. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Brief Reports Source Type: research

Clozapine-Associated Myocarditis: A Protocol for Monitoring Upon Clozapine Initiation and Recommendations for How to Conduct a Clozapine Rechallenge
Conclusions In both cases, the patients showed marked improvement in their psychiatric symptoms and functioning, demonstrating the importance of considering rechallenge in patients after CAM. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Brief Reports Source Type: research

Efficacy of Vortioxetine Monotherapy for Posttraumatic Stress Disorder: A Randomized, Placebo-Controlled Trial
Conclusions In this study of 41 patients, vortioxetine did not demonstrate superiority over placebo for adults with PTSD. Future PTSD trials may benefit from stratifying the randomization based on number of years since the index traumatic event and a history of failure to respond to treatment. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

Acute Psychological Adverse Reactions in First-Time Ritual Ayahuasca Users: A Prospective Case Series
Conclusions Based on the cases reported here, we suggest that although it is possible that participating in ayahuasca ceremonies may entail acute psychological negative reactions, those challenging experiences can also have positive long-term effects. Prospective research on the safety profile of ayahuasca and how it is affected by the context of different practices and safety strategies is therefore necessary. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

Pharmacokinetics of Coadministered Viloxazine Extended-Release (SPN-812) and Lisdexamfetamine in Healthy Adults
Conclusions Co-administration of viloxazine extended-release and lisdexamfetamine did not impact the pharmacokinetics of viloxazine or d-amphetamine relative to administration of either drug alone. After single dose administration, the combination appeared to be safe and well tolerated. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

Does the Starting of Clozapine Influence Coprescription of Other Medications?: A Study From India
Purpose/Background Little is understood about the prescription load before and after the starting of clozapine. Accordingly, this study aimed to evaluate the medication load of patients receiving clozapine, just before starting clozapine and after being on clozapine for at least 1 year. Additionally, the impact of clozapine on severity of illness was evaluated. Methods/Procedures Two hundred seventy-seven outpatients receiving clozapine were prospectively evaluated for their prescription after at least 1 year of starting clozapine. Additionally, these patients were assessed on the Clinical Global Impression-Impr...
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

European Whites May Need Lower Minimum Therapeutic Clozapine Doses Than Those Customarily Proposed
Conclusions Our recommended dosages are less than those recommended in Europe. Future studies in European Whites need to replicate these recommended doses for average metabolizer patients after sex and smoking stratification and further explore clozapine dosing for those with relevant clinical confounders. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

Menstrual Dysfunction in Women With Schizophrenia During Risperidone Maintenance Treatment
Conclusions Attention should be given to menstrual dysfunction of women with schizophrenia that is an adverse effect of risperidone maintenance treatment. Menstrual dysfunction may occur early or late during maintenance treatment, partly depending on the dose. ClinicalTrials.govidentifier: NCT00848432 (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

The Additional Effect of Individualized Prescriber-Focused Feedback on General Guideline Instruction in Reducing Antipsychotic Polypharmacy in Inpatients
Conclusions In contrast to a general intervention, the addition of an individualized intervention was effective in improving adherence to guidelines with respect to APP prescription in inpatients. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

Ambulatory Heart Rate Variability in Schizophrenia or Depression: Impact of Anticholinergic Burden and Other Factors
Background Heart rate variability (HRV) has been found reduced in patients with schizophrenia and depression. However, there is a lack of knowledge on how demographic, lifestyle, and pharmacological factors contribute to the reduction in HRV in these patients. Methods We recruited 37 patients with schizophrenia, 43 patients with unipolar depression, and 64 healthy controls. A combined chest-worn HRV and accelerometer device was used in an ambulatory measurement. Age, sex, anticholinergic burden of medication, nicotine use, body mass index, and ongoing physical activity were assessed in multiple regression models...
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

Binge Eating Disorders in Antipsychotic-Treated Patients With Schizophrenia: Prevalence, Antipsychotic Specificities, and Changes Over Time
Conclusions Binge eating disorders should be considered as important factors involved in the development of weight gain and metabolic syndrome in antipsychotic-treated patients with schizophrenia. The difficulty to reliably assess binge eating spectrum disorders in patients with psychosis is highlighted. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

Effects of Oxytocin on Emotion Recognition in Schizophrenia: A Randomized Double-Blind Pilot Study
Conclusions An acute low dose of IN-OXT had a modest effect on social cue processing and was limited to emotion recognition. Higher doses and long-term trials targeting emotional processing in SCZ may lead to improved social function. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

The Use of Methylphenidate for Cognitive Enhancement in Young Healthy Adults: The Clinical and Ethical Debates
The objective of the present debate piece is to present the ethical and clinical issues that need to be addressed in an attempt to solve this dilemma. Methods The issues presented here are systematically reviewed and discussed along the following lines: MP effectiveness in enhancing cognitive achievements in healthy people; “As these are normal healthy people, what is the duty of physicians to ‘treat’ them?”; potential benefits of cognitive enhancement to healthy people; the risks of MP; “How do these young people get their MP?”; and “What can be done?” Results Methylphenidate is widely used f...
Source: Journal of Clinical Psychopharmacology - March 1, 2021 Category: Psychiatry Tags: Commentaries Source Type: research