Journal of Clinical Psychopharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hypertensive Emergency and Stroke With Medication Interaction: A Case Report on Metoprolol and Duloxetine
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Letters to the Editors – Case Reports Source Type: research

A Potential Drug-Gene-Drug Interaction Between Cannabidiol, CYP2D6*4, and Fluoxetine: A Case Report
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Letters to the Editors – Case Reports Source Type: research

Valbenazine, Fluphenazine, and Possible Neuroleptic Malignant Syndrome in a 58-Year-Old Woman
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Letters to the Editors – Case Reports Source Type: research

Probable Interaction Between Aripiprazole and Isoniazid
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Letters to the Editors – Case Reports Source Type: research

Methylphenidate-Associated Syncope: A Case Report
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Letters to the Editors – Case Reports Source Type: research

Transfer of Ethyl Loflazepate Into Cord Blood, Breast Milk, and Infant's Serum: A Case Report
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Letters to the Editors – Case Reports Source Type: research

Depression and Catatonia Associated With Lansoprazole in an Adolescent With Phelan-McDermid Syndrome: A Case Report
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Letters to the Editors – Case Reports Source Type: research

Time for Rational Pharmacotherapy in Delusional Disorder: New Targets for Old Clinical Observations
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Letter to the Editors – Research Report Source Type: research

Esketamine for Unipolar Major Depression With Psychotic Features: A Retrospective Chart Review and Comparison With Nonpsychotic Depression
This study is a retrospective chart review of patients with major depression and current psychotic symptoms, treated with a single parenteral 0.5-mg/kg dose of esketamine. Depression symptoms were assessed at baseline and 24-hour posttreatment with the Montgomery-Åsberg Depression Rating Scale. Individuals with PMDD were matched in a 1:2 ratio to nonpsychotic MDD patients from a randomized, noninferiority clinical trial of esketamine. Findings/Results A total of 15 individuals with PMDD were included, which had higher baseline depression scores (PMDD = 40.9, MDD = 33.6, P = 0.004). A statistically significant chang...
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Brief Reports Source Type: research

Therapeutic Drug Monitoring of Paliperidone in Patients With Schizophrenia in Taiwan
Conclusions Under the suggested DD for oral and LAI paliperidone treatment, most Taiwanese patients with schizophrenia can reach the suggested therapeutic Cps range. Wide interindividual differences were observed in the Cps/DD for both the oral (7-fold) and LAI paliperidone (4-fold) groups. Compared with Western reports, no difference was observed in the body weight–adjusted Cps/DD. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Brief Reports Source Type: research

Plasma Clozapine and Norclozapine After Use of Either Crushed Tablets or Suspension Compared With Tablets
Background With clozapine, either crushed tablets suspended in an aqueous medium or proprietary suspension is sometimes prescribed as an alternative to tablets, but bioequivalence data are scant. Methods We compared clozapine dose, and plasma clozapine and N-desmethylclozapine (norclozapine) concentrations after use of either tablets or crushed tablets/suspension in samples submitted for clozapine therapeutic drug monitoring, 1993 to 2017. Results There were 846 patients (1646 samples) given crushed tablets/suspension and 6065 patients (10,779 samples) given tablets. The median dose (mg d−1) was signifi...
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Brief Reports Source Type: research

Association Between CYP2D6 Metabolizer Status and Vortioxetine Exposure and Treatment Switching: A Retrospective, Naturalistic Cohort Study Using Therapeutic Drug Monitoring Data From 640 Patients
Purpose The antidepressant vortioxetine is mainly metabolized by the polymorphic enzyme CYP2D6. The aim of this study was to investigate the absolute serum concentrations of vortioxetine and frequency of switching to an alternative antidepressant in relation to CYP2D6 genotype in a naturalistic patient population. Methods The analyses included data from 640 CYP2D6-genotyped patients treated with vortioxetine from a Norwegian therapeutic drug monitoring database. Serum concentration of vortioxetine was determined using ultrahigh-performance liquid chromatography—high-resolution mass spectrometry, whereas longit...
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Brief Reports Source Type: research

Clozapine Rechallenge or Continuation Despite Neutropenia, an Extended Follow-up of a Consecutive Quebec Case Series
Conclusions This study adds further data on the subject of clozapine rechallenge or continuation despite neutropenia. Clozapine rechallenge after agranulocytosis may be less perilous than first thought, but a systematic review on this specific subject is needed. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Brief Reports Source Type: research

Paliperidone Extended Release Versus Olanzapine in Treatment-Resistant Schizophrenia: A Randomized, Double-Blind, Multicenter Study
Conclusions Paliperidone ER could be a safe alternative for treatment-resistant schizophrenia. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Original Contributions Source Type: research

Acute Cognitive Effects of the Dual Orexin Receptor Antagonist Lemborexant Compared With Suvorexant and Zolpidem in Recreational Sedative Users
Purpose/Background As part of a human abuse potential (HAP) study of lemborexant (LEM), the effects of therapeutic (LEM 10 mg), and supratherapeutic doses of LEM 20 mg and LEM 30 mg on cognition and psychomotor performance were compared with placebo (PBO) and supratherapeutic doses of zolpidem (ZOL) 30 mg and suvorexant (SUV) 40 mg. Subjects (n = 32) were healthy, nondependent, recreational sedative users able to discriminate the effects of both SUV and ZOL from PBO on subjective drug measures. Methods/Procedures The human abuse potential study was a single-dose, randomized, double-blind, PBO-controlled, 6-way c...
Source: Journal of Clinical Psychopharmacology - July 1, 2022 Category: Psychiatry Tags: Original Contributions Source Type: research