Diurnal Variability in Neutrophil Counts in Clozapine Treatment: A Case Report and Review of the Literature
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Rechallenge Following Clozapine-Associated Eosinophilia: A Case Report and Literature Review
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Minimal Effects of Binaural Auditory Beats for Subclinical Insomnia: A Randomized Double-Blind Controlled Study
Conclusions Auditory θ BB with music does not induce evident improvement of sleep disturbances more than does pure music, but could alter brain activity toward increasing daytime alertness in subclinical insomnia, which needs to be corroborated in a clinical population. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Brief Reports Source Type: research

Evaluation of Prescribing Patterns of Long-Acting Injectable Antipsychotics Within a Community Health System
Conclusions Inconsistencies were observed between labeling information and clinical practice for LAIAs prescribed within the community health system. Patients who are more symptomatic and have additional psychological comorbidities are commonly excluded from clinical trials. Alternative dosing may be clinically necessary to obtain an adequate response, and this may have been captured in this review. This analysis may be hypothesis generating for future studies on LAIAs. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Brief Reports Source Type: research

Pharmacokinetics of Single Doses of Methadone and Buprenorphine in Blood and Oral Fluid in Healthy Volunteers and Correlation With Effects on Psychomotor and Cognitive Functions
Conclusions Concentrations of methadone and buprenorphine in blood and oral fluid showed large interindividual variations. No concentration-effect correlations were found for methadone, whereas low to moderate correlations were observed between buprenorphine concentration and driving, psychomotor function, and subjective rating of sleep and alertness. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Brief Reports Source Type: research

Smoking Is Associated With Lower Dose–Corrected Serum Concentrations of Escitalopram
Background Tobacco smoking rates in depressive patients are higher compared with the general population. Smoking was demonstrated to accelerate the metabolism of different drugs metabolized by CYP1A2, but possibly also by CYP2C19 and CYP3A4. The principle aim of the present investigation from 2015 to 2018 was to determine the differences in the pharmacokinetics of escitalopram between smokers and nonsmokers. Methods A group of nonsmokers (n = 88) was compared with smokers (n = 36), both receiving escitalopram, using the Mann-Whitney U test. Linear regression analysis was used to account for the impact of escitalopram ...
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Brief Reports Source Type: research

The Use of Antidepressant Medications During Pregnancy and the Risk of Neonatal Seizures: A Systematic Review
Purpose This review examined the current literature about the potential relationship between the use of antidepressants during pregnancy and neonatal seizures. Methods PubMed was searched for English language reports published between January 1, 1996, and October 31, 2018, by using combinations of the following key words: pregnancy, neonatal outcome, neonatal convulsion, neonatal seizure, SSRI, selective serotonin norepinephrine reuptake inhibitor (SNRI), tricyclic antidepressant (TCA), antidepressants, sertraline, fluoxetine, paroxetine, citalopram, escitalopram, fluvoxamine, venlafaxine, mirtazapine, duloxetine, bup...
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Review Articles Source Type: research

Mortality Risk of Atypical Antipsychotics for Behavioral and Psychological Symptoms of Dementia: A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis of Randomized Controlled Trials
Conclusions Atypical antipsychotics are associated with increased short-term mortality risk, although a disease-drug interaction may contribute to such risk in people with dementia. Patients with dementia may still benefit by AAPs after appropriate assessment of the disease severity as well as the dosage of AAPs, treatment duration, and monitoring of AAPs. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Review Articles Source Type: research

The Potential for Pharmacokinetic Interactions Between Cannabis Products and Conventional Medications
Conclusions Medications that are prominent substrates for CYP2C19, CYP2C9, and CYP1A2 may be particularly at risk of altered disposition by concomitant use of cannabis or 1 or more of its constituents. Caution should also be given when coadministered drugs are metabolized by UGT or CES1, on which subject the information remains limited and further investigation is warranted. Conversely, conventional drugs with strong inhibitory or inductive effects on CYP3A4 are expected to affect CBD disposition. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Review Articles Source Type: research

The Efficacy of Modafinil as a Cognitive Enhancer: A Systematic Review and Meta-Analysis
Background Animal models and human studies have identified the potential of modafinil as a cognitive enhancing agent, independent of its effects on promoting wakefulness in sleep-deprived samples. Given that single-dose applications of other putative memory enhancers (eg, D-cycloserine, yohimbine, and methylene blue) have shown success in enhancing clinical outcomes for anxiety-related disorders, we conducted a meta-analytic review examining the potential for single-dose effects for modafinil on cognitive functioning in non–sleep-deprived adults. Methods A total of 19 placebo-controlled trials that examined the ...
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Driving Simulator Performance After Administration of Analgesic Doses of Ketamine With Dexmedetomidine or Fentanyl
Purpose/Background As a sole agent, ketamine acutely compromises driving ability; however, performance after coadministration with the adjuvant sedating agents dexmedetomidine or fentanyl is unclear. Methods/Procedures Using a randomized within-subject design, 39 participants (mean ± SD age, 28.4 ± 5.8 years) received 0.3 mg/kg bolus followed by 0.15 mg kg−1 h−1 infusion of ketamine (3-hour duration), in addition to either (i) 0.7 μg kg−1 h−1 infusion of dexmedetomidine for 1.5 hours (n = 19; KET/DEX) or (ii) three 25 μg fentanyl injections for 1.5 hours (n = 20; KET/FENT). ...
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Long-Acting Injectables Versus Oral Antipsychotics: A Retrospective Bidirectional Mirror-Image Study
Conclusions The findings endorse the relative effectiveness of LAIs over OAPs in the real world, although the inherent flaws of mirror-image studies such as expectation bias and having no parallel comparator should be considered. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Is Antipsychotic Treatment Associated With Risk of Pneumonia in People With Serious Mental Illness?: The Roles of Severity of Psychiatric Symptoms and Global Functioning
Conclusions Physical comorbidities, long duration of antipsychotic treatment, early onset, severe psychiatric symptoms, and poor global functioning are associated with pneumonia in people with serious mental illness. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Monthly Extended-Release Risperidone (RBP-7000) in the Treatment of Schizophrenia: Results From the Phase 3 Program
Conclusions Except for anticipated injection-site reactions, RBP-7000 demonstrated a favorable safety and tolerability profile similar to oral risperidone. Notably, PANSS scores continued to improve for participants from the pivotal study and remained stable for de novo participants. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Statistics Commentary Series: Commentary No. 34: The Jackknife, Bootstrapping, and Monte Carlo Methods
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Commentary Source Type: research

Learning From History to Shape Destiny
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 30, 2019 Category: Psychiatry Tags: Guest Editorial Source Type: research

Words of Caution on Using Fixed 50% Concentrations of Nitrous Oxide in Psychiatry
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Letters to the Editors Source Type: research

Reply to the Letter by Theile and Foerster on Hommers L, Scharl M, Hefner G, et al. Comedication of Valproic Acid Is Associated With Increased Metabolism of Clozapine. J Clin Psychopharmacol 2018;38: 188–192
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Letters to the Editors Source Type: research

Given the Data of Hommers and Colleagues, Valproic Acid Is Not an Unequivocal Inducer of Clozapine Metabolism
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Letters to the Editors Source Type: research

Six-Week Outcome of 2-Week Antidepressant Nonimprovers in Severe Major Depression: A Prospective Naturalistic Single-Blind Study
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Letter to the Editors — Research Report Source Type: research

Metabolic Syndrome Reversal With Cariprazine
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Low-Dose Valproate-Related Peripheral Edema in Patients With Bipolar Disorder: Two Case Reports
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Botulinum Toxin Therapy of Social Anxiety Disorder: A Case Series
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Guanfacine Treatment of Sleepwalking
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Recurrent Isolated Sleep Paralysis Following Bupropion Cessation: A Case Report
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Gemfibrozil May Decrease Norclozapine Elimination: A Case Report
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Altered Mental Status Following Paliperidone Injection
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Stimulant and Antipsychotic Use for Symptom Management of a Patient With Potocki Lupski Syndrome: Case Report
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Efficacy of Varenicline in Patients With Severe Alcohol Dependence: A Pilot Double-Blind Randomized and Controlled Study
Conclusions In this pilot trial, varenicline was shown to be well tolerated by our study population of severely alcohol-dependent patients with somatic conditions. Varenicline did not sustain alcohol abstinence or reduce the number of heavy drinking days, but it did reduce the daily amount of alcohol consumed. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Brief Reports Source Type: research

Case Reports of Aripiprazole and Problematic Gambling in Schizophrenia: A Critical Review of the Evidence
Conclusions The present review confirms that ARI may be involved in the occurrence of PG in some SZ patients. However, important information to assess causality was frequently missing, and the 2 scales used did not yield the same degree of certainty. The current article calls for including more details in future case reports and for well-powered studies carefully assessing factors such as comorbid diagnoses. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Brief Reports Source Type: research

Adverse Drug Reactions Related to Mood and Emotion in Pediatric Patients Treated for Attention Deficit/Hyperactivity Disorder: A Comparative Analysis of the US Food and Drug Administration Adverse Event Reporting System Database
Conclusions We conclude that real-world data from the US Food and Drug Administration Adverse Event Reporting System are consistent with previous evidence from meta-analyses. They support a hierarchy of drug safety for several ADRs (except self-injury/suicidality) with methylphenidate as safest, followed by atomoxetine, lisdexamfetamine, and amphetamine last. Self-injury and suicidality RORs were overall higher in children. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Brief Reports Source Type: research

Clozapine-Related Myocarditis and Rechallenge: A Case Series and Clinical Review
Conclusions Pressure to undertake a rechallenge reflects clozapine's unique role in treatment-resistant schizophrenia and absence of other comparable options. However, it is not without risk, and more research is needed to understand those at increased risk, as well as established strategies that diminish this. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Brief Reports Source Type: research

Clozapine Rechallenge Following Neuroleptic Malignant Syndrome: A Systematic Review
Conclusions Our findings suggest that rechallenge following clozapine NMS is possible, and with careful risk-benefit analysis consideration, a clozapine rechallenge can be made. A publication bias in favor of cases in which rechallenge was successful is probable and is an important limitation. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Review Article Source Type: research

Hormonal Dynamics Effect of Serum Insulin-Like Growth Factor I and Cortisol/Dehydroepiandrosterone Sulfate Ratio on Symptom Severity of Major Depressive Disorder
Background Insulin-like growth factor I (IGF-I) is a neurotrophic factor produced by the hypothalamic-pituitary-somatotropic axis and is considered a potential contributor to the pathology of major depressive disorder (MDD). Although it is known that the hypothalamic-pituitary-adrenal axis and cortisol are involved in the pathology of MDD, the association with dehydroepiandrosterone sulfate (DHEAS) remains unclear. The current study sought to clarify the relationship between these hormones and the pathology of MDD. Methods Subjects were 91 Japanese patients with a diagnosis of MDD. Serum IGF-I, cortisol, and DHEAS wer...
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Fluoxetine and Risk of Bleeding in Patients Aged 60 Years and Older Using the Korea Adverse Event Reporting System Database: A Case/Noncase Study
Conclusions We detected safety signals with total bleeding, major bleeding, and brain hemorrhage related to fluoxetine. For patients with a high risk of bleeding, such as the elderly population, prescribing antidepressants other than fluoxetine can be considered. The results of this study provide preliminary evidence of a relationship between fluoxetine and hemorrhage but have wide 95% CIs. Further pharmacoepidemiological studies will be needed to confirm the risk of bleeding associated with fluoxetine. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Attitudes Toward Long-Term Medication Use—A Comparison Between Concerned Populations and a Sample From the German General Population: An Example of Real World Evidence
Conclusions Psychiatrists and psychiatric nurses were significantly more concerned about giving an (intragluteal) injection because of concerns about patients' fears of this administration method than their matched controls. In contrast, patients' concerns about receiving an injection did not differ from their matched controls. Furthermore, we found that psychiatrists tended to believe that giving an injection might be time-consuming than giving oral medication. These results may emphasize the fact that the low rate of depot medication use is derived from subjective reservations of medical staff rather than actual negati...
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

A Novel Text Message Intervention to Improve Adherence to Stimulants in Adults With Attention Deficit/Hyperactivity Disorder
Background Attention deficit/hyperactivity disorder (ADHD) is a prevalent neurobiological disorder associated with a wide range of adverse outcomes. Although large data sets document that stimulants decrease the risks for many ADHD-associated adverse outcomes, compliance with stimulants remains very poor. The main aim of this study was to assess the effectiveness of a novel text messaging–based intervention aimed at improving the poor rate of adherence to stimulant medications in adults with ADHD. Methods Subjects were adults with ages 18 to 55, prescribed a stimulant medication for ADHD treatment. For comparato...
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Prior Antidepressant Treatment Trials May Predict a Greater Risk of Depressive Relapse During Antidepressant Maintenance Therapy
Conclusions These findings support prior evidence of a negative influence of the number of prior antidepressant treatment trials on the likelihood of response and suggest that the number of prior antidepressant trials may also be associated with a greater odds of depressive relapse, and a shorter time to relapse, during antidepressant maintenance therapy in recovered depressed subjects with bipolar II disorder. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Characteristics of Patients Experiencing Extrapyramidal Symptoms or Other Movement Disorders Related to Dopamine Receptor Blocking Agent Therapy
Conclusions To our knowledge, this is the first study to describe an association between age and BMI with the risk of akathisia and dystonia, respectively, in patients taking DRBAs. Other trends observed with age and BMI in patients developing DRBA-related EPSs support previously reported findings. Expanding the knowledge base of individual characteristics associated with the risk of developing different subtypes of EPSs or OMDs can help providers and patients anticipate and attempt to mitigate these reactions, and may ultimately improve adherence to DRBA therapy. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Model-Guided Antipsychotic Dose Reduction in Schizophrenia: A Pilot, Single-Blind Randomized Controlled Trial
Conclusions Although our model-guided dose reduction strategy was found to be comparable with no-dose change in terms of dropout rates, safety issues have to be further examined. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

A Proof-of-Concept Study Evaluating the Phosphodiesterase 10A Inhibitor PF-02545920 in the Adjunctive Treatment of Suboptimally Controlled Symptoms of Schizophrenia
Conclusions Current data and results of a prior monotherapy study in which PF-02545920 failed to differentiate from placebo refute the hypothesis that PDE10A inhibitors have use as antipsychotic agents for schizophrenia. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Quetiapine Poisoning and Factors Influencing Severity
Conclusions Quetiapine may lead to severe poisoning for which there is currently no specific treatment. Patients and practitioners should be aware of this when quetiapine is prescribed, particularly when used in combination with other medications, and in order to deal with cases of poisoning. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Efficacy and Safety of Asenapine Versus Olanzapine in Combination With Divalproex for Acute Mania: A Randomized Controlled Trial
Conclusions This study found that asenapine was an effective and well-tolerated atypical antipsychotic alternative to olanzapine in combination with divalproex for the short-term management of acute mania. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Estimating the Risk of Pneumonia in Patients With Schizophrenia Newly Receiving Clozapine: A Nationwide Cohort Study
Conclusions Several risk factors for predicting subsequent pneumonia after initial use of clozapine were explored, including older age, male, history of nonpsychiatric hospitalization, dementia, asthma, tuberculosis, benzodiazepines, valproic acid, systemic corticosteroids, and the use duration of clozapine. Clinical staff can use the risk factors to administer evidence-based treatment. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Statistics Commentary Series: Commentary No. 33: Degrees of Freedom
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Commentary Source Type: research

Risk Factors Versus Causes
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2019 Category: Psychiatry Tags: Editorial Source Type: research

Benzodiazepine Abuse in Attention-Deficit Disorder?
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - April 16, 2019 Category: Psychiatry Tags: Letters to the Editors Source Type: research

Agomelatine Effectiveness, Tolerability, and Impact on Anhedonia in Major Depression: A Pooled Analysis
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - April 16, 2019 Category: Psychiatry Tags: Letters to the Editors — Research Reports Source Type: research

Life-Threatening Angioedema Following Varenicline Administration
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - April 16, 2019 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Immediate-Release Methylphenidate–Associated Recurrent Nasal Bleeding in Siblings
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - April 16, 2019 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research