Journal of Clinical Psychopharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Trajectories of Function and Symptom Change in Desvenlafaxine Clinical Trials: Toward Personalized Treatment for Depression
Conclusions Distinct trajectories of change based on symptoms and functioning were identified among patients with MDD receiving desvenlafaxine and among patients with MDD receiving placebo. Differentiating subpopulations of patients has the potential to provide a more personalized treatment of patients with MDD. ClinicalTrials.govIdentifiers: NCT00072774; NCT00277823; NCT00300378; NCT00384033; NCT00798707; NCT00863798; NCT01121484; NCT00824291; NCT01432457. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - September 1, 2021 Category: Psychiatry Tags: Brief Reports Source Type: research

Antenatal Antidepressant Prescription Associated With Reduced Fetal Femur Length but Not Estimated Fetal Weight: A Retrospective Ultrasonographic Study
Conclusions Our evidence suggested a lack of association between antenatal antidepressant prescription and lower EFW but indicated an association with lower femur length and greater left ventricular diameter in mid-late gestation. Future research should examine the clinical implications of these findings. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - September 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

Opposite Roles for Cannabidiol and δ-9-Tetrahydrocannabinol in Psychotomimetic Effects of Cannabis Extracts: A Naturalistic Controlled Study
Conclusions This study provides evidence for both the psychotomimetic effects of THC and the antipsychotomimetic effects of CBD when it is coadministered with THC in real-world situations, which can be very relevant for the clinical practice of medical cannabis. Ultimately, this study substantiates the link between the endocannabinoid system and psychotic-like symptoms and has important implications for the understanding of schizophrenia and the therapeutic potential of CBD as an antipsychotic. Lastly, we demonstrate how reliable methodologies can be implemented in real situations to collect valid ecological evidence o...
Source: Journal of Clinical Psychopharmacology - September 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

The Effect of Therapeutic Alliance on Attitudes Toward Psychiatric Medications in Schizophrenia
Purpose/Background The differential influence of therapeutic alliance with different health care professionals on patients' medication adherence has never been examined. Methods/Procedures Ninety-five stable outpatients (91 patients with schizophrenia and 4 patients with schizoaffective disorder) were recruited. Individual, clinical, and medication factors were assessed, along with drug attitude (10-item Drug Attitude Inventory). Comparison on these factors was made between outpatients who identified psychiatrists as the health care professional most involved in their care, as compared with other health care pro...
Source: Journal of Clinical Psychopharmacology - September 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

Ayahuasca Improves Self-perception of Speech Performance in Subjects With Social Anxiety Disorder: A Pilot, Proof-of-Concept, Randomized, Placebo-Controlled Trial
Conclusions Ayahuasca improved self-perception of speech performance in socially anxious individuals. These effects occurred independent of task-related anxiety and REFE, suggesting that ayahuasca could specifically improve the cognitive aspect of speech performance. Further studies should try to unveil the mechanisms involved in the effects of ayahuasca and to better understand its effects on anxiety. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - September 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

The Effect of Clozapine on Self-reported Duration of Sleep and Its Interaction With 23 Other Medications: A 5-Year Naturalistic Study
Background Sedation is a common and incapacitating clozapine adverse effect, but the factors associated with sedation and its pharmacological management remain poorly studied. Methods We conducted a retrospective cohort study based on deidentified electronic clinical records of clozapine-treated patients from the secondary mental health care provider for Cambridgeshire and Peterborough, United Kingdom. We first evaluated cross-sectionally the influence of clozapine dose, clozapine, and norclozapine plasma levels on self-reported hours slept, as a proxy for sedation, using bivariate correlation and then the longi...
Source: Journal of Clinical Psychopharmacology - September 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

Citalopram and Cannabidiol: In Vitro and In Vivo Evidence of Pharmacokinetic Interactions Relevant to the Treatment of Anxiety Disorders in Young People
Conclusions Further pharmacokinetic examination of the interaction between CBD and citalopram/escitalopram is clearly warranted, and clinicians should be vigilant around the possibility of treatment-emergent adverse effects when CBD is introduced to patients taking these antidepressants. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - September 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

Esketamine Nasal Spray for the Rapid Reduction of Depressive Symptoms in Major Depressive Disorder With Acute Suicidal Ideation or Behavior
Conclusions Esketamine plus comprehensive standard of care rapidly reduces depressive symptoms in patients with major depressive disorder who have acute suicidal ideation or behavior, especially in those with a history of suicide attempt, providing a new treatment option for this particularly ill and vulnerable population. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - September 1, 2021 Category: Psychiatry Tags: Original Contributions Source Type: research

Antidepressant Discontinuation: In Need of Scientific Evidence
Conclusions Antidepressant discontinuation is a clinically relevant topic. There is a strong need for more robust evidence to indicate who can discontinue antidepressants, when and in which manner (how). Blinded randomized controlled trials are pivotal to optimally advise physicians, patients and policy-makers. This scientific knowledge can guide evidence-based decision making in clinical practice. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - September 1, 2021 Category: Psychiatry Tags: Commentary Source Type: research

The Placenta and Psychiatry?
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - September 1, 2021 Category: Psychiatry Tags: Guest Editorial Source Type: research

Association of Aripiprazole With Reduced Hippocampal Atrophy During Maintenance Treatment of First-Episode Schizophrenia: Erratum
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2021 Category: Psychiatry Tags: Erratum Source Type: research

Riluzole Augmentation in Posttraumatic Stress Disorder: Differential Treatment Effect in a High Hyperarousal Subtype
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2021 Category: Psychiatry Tags: Letters to the Editors – Research Reports Source Type: research

Effects of Vortioxetine Versus Placebo on Cognition and Functional Capacity in Adults With Posttraumatic Stress Disorder
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2021 Category: Psychiatry Tags: Letters to the Editors – Research Reports Source Type: research

Burning Mouth Syndrome: Case Report
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2021 Category: Psychiatry Tags: Letters to the Editors – Case Reports Source Type: research

Lamotrigine-Associated Hemophagocytic Lymphohistiocytosis
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - July 1, 2021 Category: Psychiatry Tags: Letters to the Editors – Case Reports Source Type: research