QTc Prolongation Associated With Psychiatric Medications: A Retrospective Cross-Sectional Study of Adult Inpatients
Conclusion Our retrospective review study found that the occurrence of TdP and QTc prolongation was low in this subject population. QT abnormalities were associated with known risk factors, and risk scores correlated well with QTc prolongation. Providers can use the protocol proposed in this study, which incorporates risk scores and the CredibleMeds classification system to determine the need for ECG monitoring and to guide treatment. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Brief Reports Source Type: research

Lithium Carbonate in a Poststroke Population: Exploratory Analyses of Neuroanatomical and Cognitive Outcomes
Conclusions Lithium pharmacotherapy may be associated with gray matter volume change and verbal memory improvement in stroke patients, providing a rationale for future trials assessing therapeutic potential of lithium in a poststroke population. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Brief Reports Source Type: research

Switching to Imipramine Versus Add-on Mirtazapine in Venlafaxine-Resistant Major Depression: A 10-Week Randomized Open Study
Conclusions Even though we should be cautious about generalizing these results to patients with a less severe unipolar major episodes, our study suggest that switching to imipramine is a very effective treatment option in unipolar major depressive episodes after an unsuccessful venlafaxine regimen. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Brief Reports Source Type: research

Comparison of Paliperidone Palmitate and Second-Generation Oral Antipsychotics in Terms of Medication Adherence, Side Effects, and Quality of Life
Conclusions This study demonstrated that long-acting paliperidone palmitate therapy was associated with more favorable results in terms of medication adherence, drug side effects, and quality of life compared with second-generation oral antipsychotics. However, there is a need for further, more specific, and larger-scale studies in this field. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

Assessment of the Abuse Potential of Cebranopadol in Nondependent Recreational Opioid Users: A Phase 1 Randomized Controlled Study
Conclusions These results confirm our hypothesis that cebranopadol, a nociceptin/orphanin FQ peptide/opioid receptor agonist, has lower abuse potential than hydromorphone immediate release, a pure μ-opioid peptide agonist. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

Editors’ Note: Retraction Notice
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Editors’ Note Source Type: research

Potential Explanations for Increasing Methylphenidate Use in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder in Germany From 2004 to 2013
Conclusions Our analyses suggest that the increase in MPH use in Germany was mainly influenced by an increasing ADHD prevalence and increasing amounts of dispensed MPH per person. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

Does L-Methylfolate Supplement Methylphenidate Pharmacotherapy in Attention-Deficit/Hyperactivity Disorder?: Evidence of Lack of Benefit From a Double-Blind, Placebo-Controlled, Randomized Clinical Trial
Purpose/Background Interventions for attention-deficit/hyperactivity disorder (ADHD) may be inadequate for some patients. There is evidence that supplementation with L-methylfolate augments antidepressant agent effects and thus might also augment ADHD treatment effects by a common catecholaminergic mechanism. Methods Forty-four adults with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition diagnosis of ADHD participated in a randomized, double-blind, placebo-controlled, 12-week trial of 15 mg of L-methylfolate in combination with osmotic-release oral system methylphenidate. Osmotic-release oral syste...
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

An 8-Week, Randomized, Phase 2, Double-Blind, Sequential Parallel-Group Comparison Study of Two Dose Levels of the GABAA Positive Allosteric Modulator PF-06372865 Compared With Placebo as an Adjunctive Treatment in Outpatients With Inadequate Response to Standard of Care for Generalized Anxiety Disorder
Conclusions Factors contributing to the negative results include the limited sample size and failure to explore a broader range of doses. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

Effect of Brexpiprazole on Prolactin: An Analysis of Short- and Long-Term Studies in Schizophrenia
Conclusions Small changes in prolactin levels, low proportions of patients with postbaseline elevated prolactin values, and low incidence of prolactin-related TEAEs were observed after treatment with brexpiprazole. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

Statistics Commentary Series: Commentary No. 30: Propensity Scores
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Commentary Source Type: research

Clinical Psychopharmacology in Switzerland
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Guest Editorials Source Type: research

Why Do You Keep Telling Me That Drug-Drug Interactions Are Important in Psychopharmacology When I Do Not See Them in My Clinical Practice?: My Failure to Convince Clinicians
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Guest Editorials Source Type: research

Subject Index 2018
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Miscellaneous Source Type: research

Author Index 2018
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Miscellaneous Source Type: research

Acetazolamide for Antipsychotic-Associated Weight Gain in Schizophrenia
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Letters to the Editors — Research Reports Source Type: research

Antisense Oligonucleotides in Psychiatric Disorders
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Letters to the Editors — Research Reports Source Type: research

Treatment Continuation of 3 Second-Generation Antipsychotic Long-Acting Injections, and Oral Paliperidone in Patients With Schizophrenia for 2 Years
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Hallucinogen Persisting Perception Disorder After Ibogaine Treatment for Opioid Dependence
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Possible Interactions Between 5-HT2A Receptors and the Endocannabinoid System in Humans: Preliminary Evidence of Interactive Effects of Ayahuasca and Endocannabinoids in a Healthy Human Subject
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Clozapine for the Management of Suicidal Behavior in Borderline Personality Disorder Complicated by a Cancer Diagnosis: A Case Report and Review of the Literature
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Withdrawal-Emergent Dyskinesia After Acute Discontinuation of Risperidone in a Child With Autism Spectrum Disorder
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Myocarditis During Treatment With Clozapine in 2 Adolescent Cases
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Methylenedioxymethamphetamine (MDMA) in Psychiatry: Pros, Cons, and Suggestions
Conclusions We suggest that additional research investigating the basis for the putative beneficial effects of MDMA might reveal an effective treatment with fewer adverse effects. Suggestions of alternative treatments based on the behavioral pharmacology and toxicology of MDMA and its enantiomers are presented. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Review Articles Source Type: research

The Role of Atomoxetine for Parkinson Disease–Related Executive Dysfunction: A Systematic Review
Conclusions Based on the reviewed literature, atomoxetine continues to be a therapy of interest for the treatment of executive dysfunction in patients with Parkinson disease. Larger long-term trials are necessary to further define the role of atomoxetine for patients with Parkinson disease–related executive dysfunction. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Review Articles Source Type: research

Risperidone But Not Quetiapine Treatment Is Associated With Increased Appetite But Not Satiety Hormones in Children During An Oral Glucose Tolerance Test: A Pilot Study
Conclusions Risperidone treatment in youth is associated with elevated appetite during an OGTT, with no differences in gut peptides or adipocytokines to explain risperidone's effect on appetite. Further research is needed to explore other mediators of weight gain and metabolic dysfunction in SGA-treated youth. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Pilot Studies Source Type: research

A Pilot, Randomized Clinical Trial of Bedtime Doses of Prazosin Versus Placebo in Suicidal Posttraumatic Stress Disorder Patients With Nightmares
Conclusions This study confirmed an effect of nighttime-only prazosin on nighttime symptoms of insomnia and nightmares in suicidal PTSD patients who are experiencing nightmares. Surprisingly, the effect was in the direction opposite of what we expected. Furthermore, prazosin showed no signal on daytime measures including suicidal ideation. The results do not support a larger study of nighttime-only prazosin in suicidal PTSD patients but leave open the possibility of benefit from daytime administration of prazosin. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Pilot Studies Source Type: research

Attitudes Concerning Antipsychotic Depot Medication in the German General Population: A Representative Telephone Survey
Conclusions This study found a good acceptance of antipsychotic depot medication among the German general population in terms of willingness to receive such treatment. We argue that the clinical practitioners' assumptions that depot formulations would be refused by many patients are unsubstantiated. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Brief Reports Source Type: research

Very Low-Dose Mirtazapine (7.5 mg) in Treatment of Acute Antipsychotic-Associated Akathisia
Background Some evidence suggests that off-label use of mirtazapine (15 mg) is effective in treatment of acute antipsychotic-associated akathisia (AAA). We analyzed whether a lower dose of mirtazapine (7.5 mg) maintained its antiakathisia properties while exhibiting better tolerability in patients with schizophrenia and mood disorders who developed acute AAA. Methods Medical charts were retrospectively evaluated for 12 patients with AAA. All scored at least 2 (mild akathisia) on the Barnes Akathisia Rating Scale (BARS) and were treated with mirtazapine (7.5 mg) for a mean of 10.3 days. Results There was a statistic...
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Brief Reports Source Type: research

Predicting Unsuccessful Clozapine Treatment After First Use in Adult Patients With Psychotic Disorders
Conclusions The likelihood of unsuccessful clozapine treatment after 1 year was higher among patients who started clozapine as outpatients. Despite the use of a diversity of variables and different statistical approaches, it was not possible to make a simple prediction model for unsuccessful clozapine treatment using relatively easily accessible data. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

Trends of Polypharmacy and Prescription Patterns of Antidepressants in Asia
Purpose Little is known regarding the trend of polypharmacy in Asia. We used data from 5 Asian countries to examine the patterns of antidepressant (AD) prescription and trends of psychotropic polypharmacy over time. Methods We used the cross-sectional, pharmacoepidemiological data from 2004 and 2013 REAP-AD (Research on Asian Psychotropic Prescription Patterns for Antidepressants) to examine the patterns of AD prescriptions in clinical settings in China, Japan, Korea, Singapore, and Taiwan. We compared the trend in polypharmacy (ie, concomitant use of ≥2 classes of psychotropic) among individuals receiving AD presc...
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

Efficacy and Safety of a Rapid Intravenous Injection of Ketamine 0.5 mg/kg in Treatment-Resistant Major Depression: An Open 4-Week Longitudinal Study
Conclusions This study suggests that in well-controlled medical settings with adequate monitoring, a single rapid 1-minute injection of ketamine 0.5 mg/kg can be well tolerated and is efficacious in rapidly reducing depression symptoms and suicidal thoughts in outpatients with TRD. These findings are relevant to the practice of general clinical psychiatry and emergency departments were ketamine can have a place in acute management of TRD. Larger studies are necessary to confirm these results. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

Clinical Characteristics of Patients With Schizophrenia Who Successfully Discontinued Antipsychotics: A Literature Review
Conclusions Although this literature review suggests some predictors for successful antipsychotic withdrawal in patients with schizophrenia, the very limited evidence base and unequivocally high relapse rates after discontinuation must remain a matter of serious debate for risk/benefit considerations. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

Eleven Years of Clozapine Experience in Autism Spectrum Disorder: Efficacy and Tolerance
Conclusions Our study confirms that clozapine could be an efficacious and well-tolerated treatment for ASD patients with disruptive behaviors who do not respond to other antipsychotics on the long term. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

Age Impacts Olanzapine Exposure Differently During Use of Oral Versus Long-Acting Injectable Formulations: An Observational Study Including 8,288 Patients
Purpose Olanzapine is a commonly prescribed antipsychotic available as oral and long-acting injectable (LAI) formulations. Data are lacking on the use and safety of olanzapine-LAI in older patients. The aim of this study was to investigate the effect of increasing age on olanzapine exposure during oral versus LAI administration in a real-life setting. Methods This observational study was based on routine therapeutic drug monitoring data collected during 2005–2017. As a measure of exposure, absolute concentrations and concentration/dose ratios of olanzapine were defined as outcome variables. Linear mixed-model an...
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

The Relationship Between Pregnancy Exposure to Antidepressant and Atypical Antipsychotic Medications and Placental Weight and Birth Weight Ratio: A Retrospective Cohort Study
Conclusions The use of antidepressant medication, alone or in combination, has a significant effect on placental weight and PBW ratio after adjusting for confounding variables. Given that this may reflect adverse effects on intrauterine growth and have possible long-term implications for the fetus, further research is warranted to confirm these findings. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

Electroencephalogram Modifications Associated With Atypical Strict Antipsychotic Monotherapies
Conclusions Atypical antipsychotics (clozapine, aripiprazole, quetiapine, olanzapine, and risperidone) induce EEG modifications, and these are significantly greater for clozapine and appear dependent on chlorpromazine equivalent dose. No encephalopathy was observed in these antipsychotic monotherapies, whatever dose. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research

A Useful Example of Pharmaco-Electroencephalogram Science: Invited Commentary on Article by Dr Dias Alves
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Commentaries Source Type: research

Statistics Commentary Series: Commentary No. 29 Network Meta-Analysis
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Commentaries Source Type: research

In Memoriam: Bernard J. Carroll, MD, PhD
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Memorial Note Source Type: research

Is There Always a Right or Wrong?: Comments on the FDA Warnings About Triptans and the Serotonin Syndrome
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 2, 2018 Category: Psychiatry Tags: Editorial Source Type: research

Salute to Our Reviewers—2017–2018
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 29, 2018 Category: Psychiatry Tags: Miscellaneous Source Type: research

The Role of C-Reactive Protein in Early Detection of Myocarditis Associated With Clozapine
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 29, 2018 Category: Psychiatry Tags: Letter to the Editors — Research Report Source Type: research

A Case of Hypersexuality Probably Associated With Lurasidone
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 29, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Bupropion Switch for a Depressed Patient With Venlafaxine-Associated Night Sweats
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 29, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Ineffectiveness of Repeated Intravenous Ketamine Infusions in Treatment-Resistant Depression After a Post–Ketamine Relapse: Time for a Rethink?
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 29, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Melatonin Treatment of Visual Hallucinations in Parkinson Disease
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 29, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Zero Eosinophil Count as a Predictor of Clozapine-Associated Late-Onset Agranulocytosis: A Case Report
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 29, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Treatment of Risperidone-Associated Hyperprolactinemia With Aripiprazole
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 29, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research

Switching From Tobacco Smoking to Electronic Cigarettes and the Impact on Clozapine Levels
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 29, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research