MEK/ERK and PI3K/AKT pathway inhibitors affect the transformation of myelodysplastic syndrome into acute myeloid leukemia via H3K27me3 methylases and de ‑methylases
Int J Oncol. 2023 Dec;63(6):140. doi: 10.3892/ijo.2023.5588. Epub 2023 Nov 3.ABSTRACTThe transformation of myelodysplastic syndrome (MDS) into acute myeloid leukemia (AML) poses a significant clinical challenge. The trimethylation of H3 on lysine 27 (H3K27me3) methylase and de‑methylase pathway is involved in the regulation of MDS progression. The present study investigated the functional mechanisms of the MEK/ERK and PI3K/AKT pathways in the MDS‑to‑AML transformation. MDS‑AML mouse and SKM‑1 cell models were first established and this was followed by treatment with the MEK/ERK pathway inhibitor, U0126, the PI3K/...
Source: International Journal of Oncology - November 3, 2023 Category: Cancer & Oncology Authors: Zhuanzhen Zheng Xiuhua Chen Yaofang Zhang Fanggang Ren Yanping Ma Source Type: research
The apelin ‑apelin receptor signaling pathway in fibroblasts is involved in tumor growth via p53 expression of cancer cells
Int J Oncol. 2023 Dec;63(6):139. doi: 10.3892/ijo.2023.5587. Epub 2023 Nov 3.ABSTRACTCancer‑associated fibroblasts (CAFs) are pivotal in tumor progression. TP53‑deficiency in cancer cells is associated with robust stromal activation. The apelin‑apelin receptor (APJ) system has been implicated in suppressing fibroblast‑to‑myofibroblast transition in non‑neoplastic organ fibrosis. The present study aimed to elucidate the oncogenic role of the apelin‑APJ system in tumor fibroblasts. APJ expression and the effect of APJ suppression in fibroblasts were investigated for p53 status in cancer cells using human cell l...
Source: International Journal of Oncology - November 3, 2023 Category: Cancer & Oncology Authors: Hirotsugu Saiki Yoshito Hayashi Shunsuke Yoshii Eiji Kimura Kentaro Nakagawa Minoru Kato Ryotaro Uema Takanori Inoue Akihiko Sakatani Takeo Yoshihara Yoshiki Tsujii Shinichiro Shinzaki Hideki Iijima Tetsuo Takehara Source Type: research
Knockdown of lncRNA < em > MALAT1 < /em > induces pyroptosis by regulating the miR ‑124/SIRT1 axis in cervical cancer cells
In conclusion, the lncRNA MALAT1/miR‑124/SIRT1 regulatory axis in cervical cancer cells may mediate pyroptosis and may provide potential targets against the progression of cervical cancer.PMID:37921054 | DOI:10.3892/ijo.2023.5586 (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 3, 2023 Category: Cancer & Oncology Authors: Tian Liang Tong Lu Weiwei Jia Runze Li Min Jiang Yu Jiao Yuchen Wang Shanshan Cong Xinyan Jiang Lina Dong Yingyu Zhou Guangmei Zhang Dan Xiao Source Type: research
MEK/ERK and PI3K/AKT pathway inhibitors affect the transformation of myelodysplastic syndrome into acute myeloid leukemia via H3K27me3 methylases and de ‑methylases
Int J Oncol. 2023 Dec;63(6):140. doi: 10.3892/ijo.2023.5588. Epub 2023 Nov 3.ABSTRACTThe transformation of myelodysplastic syndrome (MDS) into acute myeloid leukemia (AML) poses a significant clinical challenge. The trimethylation of H3 on lysine 27 (H3K27me3) methylase and de‑methylase pathway is involved in the regulation of MDS progression. The present study investigated the functional mechanisms of the MEK/ERK and PI3K/AKT pathways in the MDS‑to‑AML transformation. MDS‑AML mouse and SKM‑1 cell models were first established and this was followed by treatment with the MEK/ERK pathway inhibitor, U0126, the PI3K/...
Source: International Journal of Oncology - November 3, 2023 Category: Cancer & Oncology Authors: Zhuanzhen Zheng Xiuhua Chen Yaofang Zhang Fanggang Ren Yanping Ma Source Type: research
The apelin ‑apelin receptor signaling pathway in fibroblasts is involved in tumor growth via p53 expression of cancer cells
Int J Oncol. 2023 Dec;63(6):139. doi: 10.3892/ijo.2023.5587. Epub 2023 Nov 3.ABSTRACTCancer‑associated fibroblasts (CAFs) are pivotal in tumor progression. TP53‑deficiency in cancer cells is associated with robust stromal activation. The apelin‑apelin receptor (APJ) system has been implicated in suppressing fibroblast‑to‑myofibroblast transition in non‑neoplastic organ fibrosis. The present study aimed to elucidate the oncogenic role of the apelin‑APJ system in tumor fibroblasts. APJ expression and the effect of APJ suppression in fibroblasts were investigated for p53 status in cancer cells using human cell l...
Source: International Journal of Oncology - November 3, 2023 Category: Cancer & Oncology Authors: Hirotsugu Saiki Yoshito Hayashi Shunsuke Yoshii Eiji Kimura Kentaro Nakagawa Minoru Kato Ryotaro Uema Takanori Inoue Akihiko Sakatani Takeo Yoshihara Yoshiki Tsujii Shinichiro Shinzaki Hideki Iijima Tetsuo Takehara Source Type: research
