Prolyl hydroxylase 2 inhibits glycolytic activity in colorectal cancer via the NF ‑κB signaling pathway
In conclusion, the data demonstrated that PHD2/Ikkβ/NF‑κB signaling has critical roles in regulating glycolysis and suggests that PHD2 potentially suppresses colorectal cancer.PMID:37975227 | DOI:10.3892/ijo.2023.5590 (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 17, 2023 Category: Cancer & Oncology Authors: Lisha Xiang Hao Wei Wentao Ye Shuang Wu Ganfeng Xie Source Type: research
Prolyl hydroxylase 2 inhibits glycolytic activity in colorectal cancer via the NF ‑κB signaling pathway
In conclusion, the data demonstrated that PHD2/Ikkβ/NF‑κB signaling has critical roles in regulating glycolysis and suggests that PHD2 potentially suppresses colorectal cancer.PMID:37975227 | DOI:10.3892/ijo.2023.5590 (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 17, 2023 Category: Cancer & Oncology Authors: Lisha Xiang Hao Wei Wentao Ye Shuang Wu Ganfeng Xie Source Type: research
Prolyl hydroxylase 2 inhibits glycolytic activity in colorectal cancer via the NF ‑κB signaling pathway
In conclusion, the data demonstrated that PHD2/Ikkβ/NF‑κB signaling has critical roles in regulating glycolysis and suggests that PHD2 potentially suppresses colorectal cancer.PMID:37975227 | DOI:10.3892/ijo.2023.5590 (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 17, 2023 Category: Cancer & Oncology Authors: Lisha Xiang Hao Wei Wentao Ye Shuang Wu Ganfeng Xie Source Type: research
Prolyl hydroxylase 2 inhibits glycolytic activity in colorectal cancer via the NF ‑κB signaling pathway
In conclusion, the data demonstrated that PHD2/Ikkβ/NF‑κB signaling has critical roles in regulating glycolysis and suggests that PHD2 potentially suppresses colorectal cancer.PMID:37975227 | DOI:10.3892/ijo.2023.5590 (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 17, 2023 Category: Cancer & Oncology Authors: Lisha Xiang Hao Wei Wentao Ye Shuang Wu Ganfeng Xie Source Type: research
Prolyl hydroxylase 2 inhibits glycolytic activity in colorectal cancer via the NF ‑κB signaling pathway
In conclusion, the data demonstrated that PHD2/Ikkβ/NF‑κB signaling has critical roles in regulating glycolysis and suggests that PHD2 potentially suppresses colorectal cancer.PMID:37975227 | DOI:10.3892/ijo.2023.5590 (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 17, 2023 Category: Cancer & Oncology Authors: Lisha Xiang Hao Wei Wentao Ye Shuang Wu Ganfeng Xie Source Type: research
Endoplasmic reticulum regulation of glucose metabolism in glioma stem cells
Int J Oncol. 2024 Jan;64(1):1. doi: 10.3892/ijo.2023.5589. Epub 2023 Nov 8.ABSTRACTGlioblastoma (GBM) treatment is extremely challenging due to the high complexity of the tumor. It is one of the tumors in which a subpopulation of highly resistant glioma initiating cells (GICs) has been clearly identified. Thus, understanding the differences between GICs and tumor bulk cells is therefore essential to move to less conventional but more efficient approaches. It was found that, unlike their differentiated progeny, GICs survival and maintenance of stem cell properties depend on mitochondrial metabolism. GICs present higher gluc...
Source: International Journal of Oncology - November 8, 2023 Category: Cancer & Oncology Authors: Mar ía Turos-Cabal Ana M S ánchez-Sánchez Noelia Puente-Moncada Federico Herrera Jezabel Rodriguez-Blanco Isaac Antolin Marco Antonio Alvarez-Vega Carmen Rodr íguez Vanesa Mart ín Source Type: research
Endoplasmic reticulum regulation of glucose metabolism in glioma stem cells
Int J Oncol. 2024 Jan;64(1):1. doi: 10.3892/ijo.2023.5589. Epub 2023 Nov 8.ABSTRACTGlioblastoma (GBM) treatment is extremely challenging due to the high complexity of the tumor. It is one of the tumors in which a subpopulation of highly resistant glioma initiating cells (GICs) has been clearly identified. Thus, understanding the differences between GICs and tumor bulk cells is therefore essential to move to less conventional but more efficient approaches. It was found that, unlike their differentiated progeny, GICs survival and maintenance of stem cell properties depend on mitochondrial metabolism. GICs present higher gluc...
Source: International Journal of Oncology - November 8, 2023 Category: Cancer & Oncology Authors: Mar ía Turos-Cabal Ana M S ánchez-Sánchez Noelia Puente-Moncada Federico Herrera Jezabel Rodriguez-Blanco Isaac Antolin Marco Antonio Alvarez-Vega Carmen Rodr íguez Vanesa Mart ín Source Type: research
Endoplasmic reticulum regulation of glucose metabolism in glioma stem cells
Int J Oncol. 2024 Jan;64(1):1. doi: 10.3892/ijo.2023.5589. Epub 2023 Nov 8.ABSTRACTGlioblastoma (GBM) treatment is extremely challenging due to the high complexity of the tumor. It is one of the tumors in which a subpopulation of highly resistant glioma initiating cells (GICs) has been clearly identified. Thus, understanding the differences between GICs and tumor bulk cells is therefore essential to move to less conventional but more efficient approaches. It was found that, unlike their differentiated progeny, GICs survival and maintenance of stem cell properties depend on mitochondrial metabolism. GICs present higher gluc...
Source: International Journal of Oncology - November 8, 2023 Category: Cancer & Oncology Authors: Mar ía Turos-Cabal Ana M S ánchez-Sánchez Noelia Puente-Moncada Federico Herrera Jezabel Rodriguez-Blanco Isaac Antolin Marco Antonio Alvarez-Vega Carmen Rodr íguez Vanesa Mart ín Source Type: research
Endoplasmic reticulum regulation of glucose metabolism in glioma stem cells
Int J Oncol. 2024 Jan;64(1):1. doi: 10.3892/ijo.2023.5589. Epub 2023 Nov 8.ABSTRACTGlioblastoma (GBM) treatment is extremely challenging due to the high complexity of the tumor. It is one of the tumors in which a subpopulation of highly resistant glioma initiating cells (GICs) has been clearly identified. Thus, understanding the differences between GICs and tumor bulk cells is therefore essential to move to less conventional but more efficient approaches. It was found that, unlike their differentiated progeny, GICs survival and maintenance of stem cell properties depend on mitochondrial metabolism. GICs present higher gluc...
Source: International Journal of Oncology - November 8, 2023 Category: Cancer & Oncology Authors: Mar ía Turos-Cabal Ana M S ánchez-Sánchez Noelia Puente-Moncada Federico Herrera Jezabel Rodriguez-Blanco Isaac Antolin Marco Antonio Alvarez-Vega Carmen Rodr íguez Vanesa Mart ín Source Type: research
Endoplasmic reticulum regulation of glucose metabolism in glioma stem cells
Int J Oncol. 2024 Jan;64(1):1. doi: 10.3892/ijo.2023.5589. Epub 2023 Nov 8.ABSTRACTGlioblastoma (GBM) treatment is extremely challenging due to the high complexity of the tumor. It is one of the tumors in which a subpopulation of highly resistant glioma initiating cells (GICs) has been clearly identified. Thus, understanding the differences between GICs and tumor bulk cells is therefore essential to move to less conventional but more efficient approaches. It was found that, unlike their differentiated progeny, GICs survival and maintenance of stem cell properties depend on mitochondrial metabolism. GICs present higher gluc...
Source: International Journal of Oncology - November 8, 2023 Category: Cancer & Oncology Authors: Mar ía Turos-Cabal Ana M S ánchez-Sánchez Noelia Puente-Moncada Federico Herrera Jezabel Rodriguez-Blanco Isaac Antolin Marco Antonio Alvarez-Vega Carmen Rodr íguez Vanesa Mart ín Source Type: research
Endoplasmic reticulum regulation of glucose metabolism in glioma stem cells
Int J Oncol. 2024 Jan;64(1):1. doi: 10.3892/ijo.2023.5589. Epub 2023 Nov 8.ABSTRACTGlioblastoma (GBM) treatment is extremely challenging due to the high complexity of the tumor. It is one of the tumors in which a subpopulation of highly resistant glioma initiating cells (GICs) has been clearly identified. Thus, understanding the differences between GICs and tumor bulk cells is therefore essential to move to less conventional but more efficient approaches. It was found that, unlike their differentiated progeny, GICs survival and maintenance of stem cell properties depend on mitochondrial metabolism. GICs present higher gluc...
Source: International Journal of Oncology - November 8, 2023 Category: Cancer & Oncology Authors: Mar ía Turos-Cabal Ana M S ánchez-Sánchez Noelia Puente-Moncada Federico Herrera Jezabel Rodriguez-Blanco Isaac Antolin Marco Antonio Alvarez-Vega Carmen Rodr íguez Vanesa Mart ín Source Type: research
Endoplasmic reticulum regulation of glucose metabolism in glioma stem cells
Int J Oncol. 2024 Jan;64(1):1. doi: 10.3892/ijo.2023.5589. Epub 2023 Nov 8.ABSTRACTGlioblastoma (GBM) treatment is extremely challenging due to the high complexity of the tumor. It is one of the tumors in which a subpopulation of highly resistant glioma initiating cells (GICs) has been clearly identified. Thus, understanding the differences between GICs and tumor bulk cells is therefore essential to move to less conventional but more efficient approaches. It was found that, unlike their differentiated progeny, GICs survival and maintenance of stem cell properties depend on mitochondrial metabolism. GICs present higher gluc...
Source: International Journal of Oncology - November 8, 2023 Category: Cancer & Oncology Authors: Mar ía Turos-Cabal Ana M S ánchez-Sánchez Noelia Puente-Moncada Federico Herrera Jezabel Rodriguez-Blanco Isaac Antolin Marco Antonio Alvarez-Vega Carmen Rodr íguez Vanesa Mart ín Source Type: research
Endoplasmic reticulum regulation of glucose metabolism in glioma stem cells
Int J Oncol. 2024 Jan;64(1):1. doi: 10.3892/ijo.2023.5589. Epub 2023 Nov 8.ABSTRACTGlioblastoma (GBM) treatment is extremely challenging due to the high complexity of the tumor. It is one of the tumors in which a subpopulation of highly resistant glioma initiating cells (GICs) has been clearly identified. Thus, understanding the differences between GICs and tumor bulk cells is therefore essential to move to less conventional but more efficient approaches. It was found that, unlike their differentiated progeny, GICs survival and maintenance of stem cell properties depend on mitochondrial metabolism. GICs present higher gluc...
Source: International Journal of Oncology - November 8, 2023 Category: Cancer & Oncology Authors: Mar ía Turos-Cabal Ana M S ánchez-Sánchez Noelia Puente-Moncada Federico Herrera Jezabel Rodriguez-Blanco Isaac Antolin Marco Antonio Alvarez-Vega Carmen Rodr íguez Vanesa Mart ín Source Type: research
Knockdown of lncRNA < em > MALAT1 < /em > induces pyroptosis by regulating the miR ‑124/SIRT1 axis in cervical cancer cells
In conclusion, the lncRNA MALAT1/miR‑124/SIRT1 regulatory axis in cervical cancer cells may mediate pyroptosis and may provide potential targets against the progression of cervical cancer.PMID:37921054 | DOI:10.3892/ijo.2023.5586 (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 3, 2023 Category: Cancer & Oncology Authors: Tian Liang Tong Lu Weiwei Jia Runze Li Min Jiang Yu Jiao Yuchen Wang Shanshan Cong Xinyan Jiang Lina Dong Yingyu Zhou Guangmei Zhang Dan Xiao Source Type: research
MEK/ERK and PI3K/AKT pathway inhibitors affect the transformation of myelodysplastic syndrome into acute myeloid leukemia via H3K27me3 methylases and de ‑methylases
Int J Oncol. 2023 Dec;63(6):140. doi: 10.3892/ijo.2023.5588. Epub 2023 Nov 3.ABSTRACTThe transformation of myelodysplastic syndrome (MDS) into acute myeloid leukemia (AML) poses a significant clinical challenge. The trimethylation of H3 on lysine 27 (H3K27me3) methylase and de‑methylase pathway is involved in the regulation of MDS progression. The present study investigated the functional mechanisms of the MEK/ERK and PI3K/AKT pathways in the MDS‑to‑AML transformation. MDS‑AML mouse and SKM‑1 cell models were first established and this was followed by treatment with the MEK/ERK pathway inhibitor, U0126, the PI3K/...
Source: International Journal of Oncology - November 3, 2023 Category: Cancer & Oncology Authors: Zhuanzhen Zheng Xiuhua Chen Yaofang Zhang Fanggang Ren Yanping Ma Source Type: research
