Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research