Research progress on the role of tumor ‑associated macrophages in tumor development and their use as molecular targets (Review)
Int J Oncol. 2024 Feb;64(2):11. doi: 10.3892/ijo.2023.5599. Epub 2023 Dec 8.ABSTRACTThe tumor microenvironment (TME) is a complex system composed mainly of tumor cells, mesenchymal cells and immune cells. Macrophages, also known as tumor‑associated macrophages (TAMs), among innate immune cells, are some of the most abundant components of the TME. They may influence tumor growth and metastasis through interactions with other cell populations in the TME and have been associated with poor prognosis in a variety of tumors. Therefore, a better understanding of the role of TAMs in the TME may provide new insight into tumor the...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Chenglin Lu Ying Liu Linxuan Miao Xiangle Kong Huili Li Haoran Chen Xu Zhao Bin Zhang Xiaonan Cui Source Type: research
The dual HDAC and PI3K inhibitor, CUDC ‑907, inhibits tumor growth and stem‑like properties by suppressing PTX3 in neuroblastoma
Int J Oncol. 2024 Feb;64(2):14. doi: 10.3892/ijo.2023.5602. Epub 2023 Dec 8.ABSTRACTNeuroblastoma (NB) is one of the common solid tumors in childhood and poses a threat to the lives of children. Patients with advanced‑stage or recurrent NB have a poor prognosis. CUDC‑907, as a novel dual‑target inhibitor of histone deacetylase (HDAC) and phosphatidylinositol‑3‑kinase (PI3K), has been proven to play an antitumor role in several types of tumors. However, the exact role of CUDC‑907 in NB remains unclear. In the present study, in vivo and in vitro assays were performed to investigate the anti‑NB activity of CUDCâ...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Mengzhen Li Yang Hu Juan Wang Yanjie Xu Ye Hong Li Zhang Qiuyun Luo Zijun Zhen Suying Lu Junting Huang Jia Zhu Yizhuo Zhang Yi Que Feifei Sun Source Type: research
m < sup > 6 < /sup > A ‑modified HOXC10 promotes HNSCC progression via co‑activation of ADAM17/EGFR and Wnt/β‑catenin signaling
Int J Oncol. 2024 Feb;64(2):10. doi: 10.3892/ijo.2023.5598. Epub 2023 Dec 8.ABSTRACTThe homeobox (HOX) gene family plays a fundamental role in carcinogenesis. However, the oncogenic mechanism of HOXC10 in head and neck squamous cell carcinoma (HNSCC) remains unclear. In the present study, it was revealed that HOXC10 expression was significantly higher in HNSCC tissues than in adjacent tissues, and a high level of HOXC10 was closely associated with worse clinical outcomes. HOXC10 overexpression promoted HNSCC cell proliferation, migration, and invasion, both in vitro and in vivo. Mechanistically, chromatin immunoprecipitati...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Yujuan Zhou Qiang Huang Chunping Wu Ye Xu Yang Guo Xiaohui Yuan Chengzhi Xu Liang Zhou Source Type: research
Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis
Int J Oncol. 2024 Feb;64(2):12. doi: 10.3892/ijo.2023.5600. Epub 2023 Dec 8.ABSTRACTRAD51 recombinase is one of the DNA damage repair proteins associated with breast cancer risk. Apart from its function to maintain genomic integrity within the cell nucleus, RAD51 localized to the cytoplasm has also been implicated in breast malignancy. However, limited information exists on the roles of cytoplasmic vs. nuclear RAD51 in breast cancer progression and patient prognosis. In the present study, the association of cytoplasmic and nuclear RAD51 with clinical outcomes of patients with breast cancer was analyzed, revealing that elev...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Yen-Yun Wang Kuang-Hung Cheng Amos C Hung Steven Lo Pang-Yu Chen Yi-Chia Wu Ming-Feng Hou Shyng-Shiou F Yuan Source Type: research
Dual ‑directional effect of vinorelbine combined with cisplatin or fluorouracil on tumor growth and metastasis in metronomic chemotherapy in breast cancer
Int J Oncol. 2024 Feb;64(2):13. doi: 10.3892/ijo.2023.5601. Epub 2023 Dec 8.ABSTRACTMetronomic chemotherapy (MCT) regimens may be associated with risks to the patient due to the ambiguity surrounding low dosages and schedules. In the present study, metronomic regimens of vinorelbine (NVB) combined with cisplatin (CDDP) or fluorouracil (5‑FU) were chosen to study the dose‑response associations with tumor growth and metastasis, along with the underlying mechanisms in angiogenesis, apoptosis and tumor immunity, using experimental techniques such as immunofluorescence, immunohistochemistry, western blotting and flow cytome...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Hua Liu Min Li Yanlan Lin Huining You Jianrong Kou Weiyi Feng Source Type: research
[Retracted] Role of the AKT pathway in microRNA expression of human U251 glioblastoma cells
Int J Oncol. 2024 Feb;64(2):9. doi: 10.3892/ijo.2023.5597. Epub 2023 Dec 8.ABSTRACTFollowing the publication of the above article, a concerned reader drew to the Editor's attention that, regarding the western blots featured in Fig. 3B on p. 670, the bands featured in the U251 and U251‑MC lanes for the miR‑21 and U6 experiments appeared to be duplicates of each other. Moreover, certain of these data were strikingly similar to data that appeared in another article published at around the same time featuring some of the same authors (again, with apparent duplications of bands within the same gel slices, as they were prese...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Xuan Zhou Yu Ren Lei Han Mei Mei Peng Xu Chun-Zhi Zhang Guang-Xiu Wang Zhi-Fan Jia Pei-Yu Pu Chun-Sheng Kang Source Type: research
Research progress on the role of tumor ‑associated macrophages in tumor development and their use as molecular targets (Review)
Int J Oncol. 2024 Feb;64(2):11. doi: 10.3892/ijo.2023.5599. Epub 2023 Dec 8.ABSTRACTThe tumor microenvironment (TME) is a complex system composed mainly of tumor cells, mesenchymal cells and immune cells. Macrophages, also known as tumor‑associated macrophages (TAMs), among innate immune cells, are some of the most abundant components of the TME. They may influence tumor growth and metastasis through interactions with other cell populations in the TME and have been associated with poor prognosis in a variety of tumors. Therefore, a better understanding of the role of TAMs in the TME may provide new insight into tumor the...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Chenglin Lu Ying Liu Linxuan Miao Xiangle Kong Huili Li Haoran Chen Xu Zhao Bin Zhang Xiaonan Cui Source Type: research
The dual HDAC and PI3K inhibitor, CUDC ‑907, inhibits tumor growth and stem‑like properties by suppressing PTX3 in neuroblastoma
Int J Oncol. 2024 Feb;64(2):14. doi: 10.3892/ijo.2023.5602. Epub 2023 Dec 8.ABSTRACTNeuroblastoma (NB) is one of the common solid tumors in childhood and poses a threat to the lives of children. Patients with advanced‑stage or recurrent NB have a poor prognosis. CUDC‑907, as a novel dual‑target inhibitor of histone deacetylase (HDAC) and phosphatidylinositol‑3‑kinase (PI3K), has been proven to play an antitumor role in several types of tumors. However, the exact role of CUDC‑907 in NB remains unclear. In the present study, in vivo and in vitro assays were performed to investigate the anti‑NB activity of CUDCâ...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Mengzhen Li Yang Hu Juan Wang Yanjie Xu Ye Hong Li Zhang Qiuyun Luo Zijun Zhen Suying Lu Junting Huang Jia Zhu Yizhuo Zhang Yi Que Feifei Sun Source Type: research
m < sup > 6 < /sup > A ‑modified HOXC10 promotes HNSCC progression via co‑activation of ADAM17/EGFR and Wnt/β‑catenin signaling
Int J Oncol. 2024 Feb;64(2):10. doi: 10.3892/ijo.2023.5598. Epub 2023 Dec 8.ABSTRACTThe homeobox (HOX) gene family plays a fundamental role in carcinogenesis. However, the oncogenic mechanism of HOXC10 in head and neck squamous cell carcinoma (HNSCC) remains unclear. In the present study, it was revealed that HOXC10 expression was significantly higher in HNSCC tissues than in adjacent tissues, and a high level of HOXC10 was closely associated with worse clinical outcomes. HOXC10 overexpression promoted HNSCC cell proliferation, migration, and invasion, both in vitro and in vivo. Mechanistically, chromatin immunoprecipitati...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Yujuan Zhou Qiang Huang Chunping Wu Ye Xu Yang Guo Xiaohui Yuan Chengzhi Xu Liang Zhou Source Type: research
Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis
Int J Oncol. 2024 Feb;64(2):12. doi: 10.3892/ijo.2023.5600. Epub 2023 Dec 8.ABSTRACTRAD51 recombinase is one of the DNA damage repair proteins associated with breast cancer risk. Apart from its function to maintain genomic integrity within the cell nucleus, RAD51 localized to the cytoplasm has also been implicated in breast malignancy. However, limited information exists on the roles of cytoplasmic vs. nuclear RAD51 in breast cancer progression and patient prognosis. In the present study, the association of cytoplasmic and nuclear RAD51 with clinical outcomes of patients with breast cancer was analyzed, revealing that elev...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Yen-Yun Wang Kuang-Hung Cheng Amos C Hung Steven Lo Pang-Yu Chen Yi-Chia Wu Ming-Feng Hou Shyng-Shiou F Yuan Source Type: research
Dual ‑directional effect of vinorelbine combined with cisplatin or fluorouracil on tumor growth and metastasis in metronomic chemotherapy in breast cancer
Int J Oncol. 2024 Feb;64(2):13. doi: 10.3892/ijo.2023.5601. Epub 2023 Dec 8.ABSTRACTMetronomic chemotherapy (MCT) regimens may be associated with risks to the patient due to the ambiguity surrounding low dosages and schedules. In the present study, metronomic regimens of vinorelbine (NVB) combined with cisplatin (CDDP) or fluorouracil (5‑FU) were chosen to study the dose‑response associations with tumor growth and metastasis, along with the underlying mechanisms in angiogenesis, apoptosis and tumor immunity, using experimental techniques such as immunofluorescence, immunohistochemistry, western blotting and flow cytome...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Hua Liu Min Li Yanlan Lin Huining You Jianrong Kou Weiyi Feng Source Type: research
[Retracted] Role of the AKT pathway in microRNA expression of human U251 glioblastoma cells
Int J Oncol. 2024 Feb;64(2):9. doi: 10.3892/ijo.2023.5597. Epub 2023 Dec 8.ABSTRACTFollowing the publication of the above article, a concerned reader drew to the Editor's attention that, regarding the western blots featured in Fig. 3B on p. 670, the bands featured in the U251 and U251‑MC lanes for the miR‑21 and U6 experiments appeared to be duplicates of each other. Moreover, certain of these data were strikingly similar to data that appeared in another article published at around the same time featuring some of the same authors (again, with apparent duplications of bands within the same gel slices, as they were prese...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Xuan Zhou Yu Ren Lei Han Mei Mei Peng Xu Chun-Zhi Zhang Guang-Xiu Wang Zhi-Fan Jia Pei-Yu Pu Chun-Sheng Kang Source Type: research
Research progress on the role of tumor ‑associated macrophages in tumor development and their use as molecular targets (Review)
Int J Oncol. 2024 Feb;64(2):11. doi: 10.3892/ijo.2023.5599. Epub 2023 Dec 8.ABSTRACTThe tumor microenvironment (TME) is a complex system composed mainly of tumor cells, mesenchymal cells and immune cells. Macrophages, also known as tumor‑associated macrophages (TAMs), among innate immune cells, are some of the most abundant components of the TME. They may influence tumor growth and metastasis through interactions with other cell populations in the TME and have been associated with poor prognosis in a variety of tumors. Therefore, a better understanding of the role of TAMs in the TME may provide new insight into tumor the...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Chenglin Lu Ying Liu Linxuan Miao Xiangle Kong Huili Li Haoran Chen Xu Zhao Bin Zhang Xiaonan Cui Source Type: research
The dual HDAC and PI3K inhibitor, CUDC ‑907, inhibits tumor growth and stem‑like properties by suppressing PTX3 in neuroblastoma
Int J Oncol. 2024 Feb;64(2):14. doi: 10.3892/ijo.2023.5602. Epub 2023 Dec 8.ABSTRACTNeuroblastoma (NB) is one of the common solid tumors in childhood and poses a threat to the lives of children. Patients with advanced‑stage or recurrent NB have a poor prognosis. CUDC‑907, as a novel dual‑target inhibitor of histone deacetylase (HDAC) and phosphatidylinositol‑3‑kinase (PI3K), has been proven to play an antitumor role in several types of tumors. However, the exact role of CUDC‑907 in NB remains unclear. In the present study, in vivo and in vitro assays were performed to investigate the anti‑NB activity of CUDCâ...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Mengzhen Li Yang Hu Juan Wang Yanjie Xu Ye Hong Li Zhang Qiuyun Luo Zijun Zhen Suying Lu Junting Huang Jia Zhu Yizhuo Zhang Yi Que Feifei Sun Source Type: research
m < sup > 6 < /sup > A ‑modified HOXC10 promotes HNSCC progression via co‑activation of ADAM17/EGFR and Wnt/β‑catenin signaling
Int J Oncol. 2024 Feb;64(2):10. doi: 10.3892/ijo.2023.5598. Epub 2023 Dec 8.ABSTRACTThe homeobox (HOX) gene family plays a fundamental role in carcinogenesis. However, the oncogenic mechanism of HOXC10 in head and neck squamous cell carcinoma (HNSCC) remains unclear. In the present study, it was revealed that HOXC10 expression was significantly higher in HNSCC tissues than in adjacent tissues, and a high level of HOXC10 was closely associated with worse clinical outcomes. HOXC10 overexpression promoted HNSCC cell proliferation, migration, and invasion, both in vitro and in vivo. Mechanistically, chromatin immunoprecipitati...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Yujuan Zhou Qiang Huang Chunping Wu Ye Xu Yang Guo Xiaohui Yuan Chengzhi Xu Liang Zhou Source Type: research
