Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis
Int J Oncol. 2024 Feb;64(2):12. doi: 10.3892/ijo.2023.5600. Epub 2023 Dec 8.ABSTRACTRAD51 recombinase is one of the DNA damage repair proteins associated with breast cancer risk. Apart from its function to maintain genomic integrity within the cell nucleus, RAD51 localized to the cytoplasm has also been implicated in breast malignancy. However, limited information exists on the roles of cytoplasmic vs. nuclear RAD51 in breast cancer progression and patient prognosis. In the present study, the association of cytoplasmic and nuclear RAD51 with clinical outcomes of patients with breast cancer was analyzed, revealing that elev...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Yen-Yun Wang Kuang-Hung Cheng Amos C Hung Steven Lo Pang-Yu Chen Yi-Chia Wu Ming-Feng Hou Shyng-Shiou F Yuan Source Type: research
Dual ‑directional effect of vinorelbine combined with cisplatin or fluorouracil on tumor growth and metastasis in metronomic chemotherapy in breast cancer
Int J Oncol. 2024 Feb;64(2):13. doi: 10.3892/ijo.2023.5601. Epub 2023 Dec 8.ABSTRACTMetronomic chemotherapy (MCT) regimens may be associated with risks to the patient due to the ambiguity surrounding low dosages and schedules. In the present study, metronomic regimens of vinorelbine (NVB) combined with cisplatin (CDDP) or fluorouracil (5‑FU) were chosen to study the dose‑response associations with tumor growth and metastasis, along with the underlying mechanisms in angiogenesis, apoptosis and tumor immunity, using experimental techniques such as immunofluorescence, immunohistochemistry, western blotting and flow cytome...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Hua Liu Min Li Yanlan Lin Huining You Jianrong Kou Weiyi Feng Source Type: research
[Retracted] Role of the AKT pathway in microRNA expression of human U251 glioblastoma cells
Int J Oncol. 2024 Feb;64(2):9. doi: 10.3892/ijo.2023.5597. Epub 2023 Dec 8.ABSTRACTFollowing the publication of the above article, a concerned reader drew to the Editor's attention that, regarding the western blots featured in Fig. 3B on p. 670, the bands featured in the U251 and U251‑MC lanes for the miR‑21 and U6 experiments appeared to be duplicates of each other. Moreover, certain of these data were strikingly similar to data that appeared in another article published at around the same time featuring some of the same authors (again, with apparent duplications of bands within the same gel slices, as they were prese...
Source: International Journal of Oncology - December 8, 2023 Category: Cancer & Oncology Authors: Xuan Zhou Yu Ren Lei Han Mei Mei Peng Xu Chun-Zhi Zhang Guang-Xiu Wang Zhi-Fan Jia Pei-Yu Pu Chun-Sheng Kang Source Type: research
Endocrine nuclear receptors and long non ‑coding RNAs reciprocal regulation in cancer (Review)
Int J Oncol. 2024 Jan;64(1):7. doi: 10.3892/ijo.2023.5595. Epub 2023 Dec 1.ABSTRACTNuclear receptors (NRs) are transcriptional regulators involved in different aspects of normal cell physiology. Their deregulation is associated with aberrant expression, gene mutations and/or epigenetic alterations that can be related to the pathogenesis of various human diseases, and especially in cancer. In particular, a complex genomic network involved in the development and progression of NR‑mediated cancer has been highlighted. Advanced genomic technologies have made it possible to understand that the expression of any particular NR ...
Source: International Journal of Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Monica Cantile Margherita Cerrone Maurizio Di Bonito Pasquale Moccia Maura Tracey Gerardo Ferrara Alfredo Budillon Source Type: research
[Corrigendum] Long non ‑coding RNA CASC11 interacts with YBX1 to promote prostate cancer progression by suppressing the p53 pathway
Int J Oncol. 2024 Jan;64(1):5. doi: 10.3892/ijo.2023.5593. Epub 2023 Dec 1.ABSTRACTSubsequently to the publication of the above article, an interested reader drew to the authors' attention that, concerning the Transwell assay experiments shown in Fig. 3G and I on p. 8, the data panel showing the result of the 'LNCaP / sh‑CASCS11‑1' experiment in Fig. 3G appeared to be overlapping with the 'LNCaP / Vector' experiment in Fig. 3I, even though the data were intended to have shown the results from differently performed experiments. After having re‑examined their original data, the authors have realized that Fig. 3G and I ...
Source: International Journal of Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Xianchao Sun Shiyong Xin Ying Zhang Liang Jin Xiang Liu Jiaxin Zhang Wangli Mei Bihui Zhang Weiguo Ma Lin Ye Source Type: research
CHMP3 promotes the progression of hepatocellular carcinoma by inhibiting caspase ‑1‑dependent pyroptosis
In conclusion, CHMP3 may affect the development of liver cancer through the caspase‑1‑mediated pyroptosis pathway.PMID:38038147 | DOI:10.3892/ijo.2023.5596 (Source: International Journal of Oncology)
Source: International Journal of Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Yuting Zheng Shaojie Yang Wanlin Dai Jingnan Wang Shiyuan Bi Xiaolin Zhang Zhuyuan Zheng Yang Sun Shuodong Wu Jing Kong Source Type: research
Function of microRNA ‑124 in the pathogenesis of cancer (Review)
Int J Oncol. 2024 Jan;64(1):6. doi: 10.3892/ijo.2023.5594. Epub 2023 Dec 1.ABSTRACTNon‑coding RNAs with a length of 22‑24 nt are known as microRNAs (miRNAs or miRs), which are critical regulators of protein translation. Over the past 10 years, the roles of miRNAs have been extensively investigated in several human cancer types. There is evidence to indicate that miRNAs regulate gene expression by concentrating on a number of substances that have an impact on the physiology and development of cancer cells. Thus, miRNAs as regarded as effective targets for further studies on the design of novel therapeutic strategies. He...
Source: International Journal of Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Yuchen Liu Yipin Yang Xinyi Wang Siyue Yin Bingyu Liang Yuchen Zhang Min Fan Ziyue Fu Chuanlu Shen Yanxun Han Bangjie Chen Qian Zhang Source Type: research
Endocrine nuclear receptors and long non ‑coding RNAs reciprocal regulation in cancer (Review)
Int J Oncol. 2024 Jan;64(1):7. doi: 10.3892/ijo.2023.5595. Epub 2023 Dec 1.ABSTRACTNuclear receptors (NRs) are transcriptional regulators involved in different aspects of normal cell physiology. Their deregulation is associated with aberrant expression, gene mutations and/or epigenetic alterations that can be related to the pathogenesis of various human diseases, and especially in cancer. In particular, a complex genomic network involved in the development and progression of NR‑mediated cancer has been highlighted. Advanced genomic technologies have made it possible to understand that the expression of any particular NR ...
Source: International Journal of Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Monica Cantile Margherita Cerrone Maurizio Di Bonito Pasquale Moccia Maura Tracey Gerardo Ferrara Alfredo Budillon Source Type: research
[Corrigendum] Long non ‑coding RNA CASC11 interacts with YBX1 to promote prostate cancer progression by suppressing the p53 pathway
Int J Oncol. 2024 Jan;64(1):5. doi: 10.3892/ijo.2023.5593. Epub 2023 Dec 1.ABSTRACTSubsequently to the publication of the above article, an interested reader drew to the authors' attention that, concerning the Transwell assay experiments shown in Fig. 3G and I on p. 8, the data panel showing the result of the 'LNCaP / sh‑CASCS11‑1' experiment in Fig. 3G appeared to be overlapping with the 'LNCaP / Vector' experiment in Fig. 3I, even though the data were intended to have shown the results from differently performed experiments. After having re‑examined their original data, the authors have realized that Fig. 3G and I ...
Source: International Journal of Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Xianchao Sun Shiyong Xin Ying Zhang Liang Jin Xiang Liu Jiaxin Zhang Wangli Mei Bihui Zhang Weiguo Ma Lin Ye Source Type: research
CHMP3 promotes the progression of hepatocellular carcinoma by inhibiting caspase ‑1‑dependent pyroptosis
In conclusion, CHMP3 may affect the development of liver cancer through the caspase‑1‑mediated pyroptosis pathway.PMID:38038147 | DOI:10.3892/ijo.2023.5596 (Source: International Journal of Oncology)
Source: International Journal of Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Yuting Zheng Shaojie Yang Wanlin Dai Jingnan Wang Shiyuan Bi Xiaolin Zhang Zhuyuan Zheng Yang Sun Shuodong Wu Jing Kong Source Type: research
Function of microRNA ‑124 in the pathogenesis of cancer (Review)
Int J Oncol. 2024 Jan;64(1):6. doi: 10.3892/ijo.2023.5594. Epub 2023 Dec 1.ABSTRACTNon‑coding RNAs with a length of 22‑24 nt are known as microRNAs (miRNAs or miRs), which are critical regulators of protein translation. Over the past 10 years, the roles of miRNAs have been extensively investigated in several human cancer types. There is evidence to indicate that miRNAs regulate gene expression by concentrating on a number of substances that have an impact on the physiology and development of cancer cells. Thus, miRNAs as regarded as effective targets for further studies on the design of novel therapeutic strategies. He...
Source: International Journal of Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Yuchen Liu Yipin Yang Xinyi Wang Siyue Yin Bingyu Liang Yuchen Zhang Min Fan Ziyue Fu Chuanlu Shen Yanxun Han Bangjie Chen Qian Zhang Source Type: research
Endocrine nuclear receptors and long non ‑coding RNAs reciprocal regulation in cancer (Review)
Int J Oncol. 2024 Jan;64(1):7. doi: 10.3892/ijo.2023.5595. Epub 2023 Dec 1.ABSTRACTNuclear receptors (NRs) are transcriptional regulators involved in different aspects of normal cell physiology. Their deregulation is associated with aberrant expression, gene mutations and/or epigenetic alterations that can be related to the pathogenesis of various human diseases, and especially in cancer. In particular, a complex genomic network involved in the development and progression of NR‑mediated cancer has been highlighted. Advanced genomic technologies have made it possible to understand that the expression of any particular NR ...
Source: International Journal of Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Monica Cantile Margherita Cerrone Maurizio Di Bonito Pasquale Moccia Maura Tracey Gerardo Ferrara Alfredo Budillon Source Type: research
[Corrigendum] Long non ‑coding RNA CASC11 interacts with YBX1 to promote prostate cancer progression by suppressing the p53 pathway
Int J Oncol. 2024 Jan;64(1):5. doi: 10.3892/ijo.2023.5593. Epub 2023 Dec 1.ABSTRACTSubsequently to the publication of the above article, an interested reader drew to the authors' attention that, concerning the Transwell assay experiments shown in Fig. 3G and I on p. 8, the data panel showing the result of the 'LNCaP / sh‑CASCS11‑1' experiment in Fig. 3G appeared to be overlapping with the 'LNCaP / Vector' experiment in Fig. 3I, even though the data were intended to have shown the results from differently performed experiments. After having re‑examined their original data, the authors have realized that Fig. 3G and I ...
Source: International Journal of Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Xianchao Sun Shiyong Xin Ying Zhang Liang Jin Xiang Liu Jiaxin Zhang Wangli Mei Bihui Zhang Weiguo Ma Lin Ye Source Type: research
CHMP3 promotes the progression of hepatocellular carcinoma by inhibiting caspase ‑1‑dependent pyroptosis
In conclusion, CHMP3 may affect the development of liver cancer through the caspase‑1‑mediated pyroptosis pathway.PMID:38038147 | DOI:10.3892/ijo.2023.5596 (Source: International Journal of Oncology)
Source: International Journal of Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Yuting Zheng Shaojie Yang Wanlin Dai Jingnan Wang Shiyuan Bi Xiaolin Zhang Zhuyuan Zheng Yang Sun Shuodong Wu Jing Kong Source Type: research
Function of microRNA ‑124 in the pathogenesis of cancer (Review)
Int J Oncol. 2024 Jan;64(1):6. doi: 10.3892/ijo.2023.5594. Epub 2023 Dec 1.ABSTRACTNon‑coding RNAs with a length of 22‑24 nt are known as microRNAs (miRNAs or miRs), which are critical regulators of protein translation. Over the past 10 years, the roles of miRNAs have been extensively investigated in several human cancer types. There is evidence to indicate that miRNAs regulate gene expression by concentrating on a number of substances that have an impact on the physiology and development of cancer cells. Thus, miRNAs as regarded as effective targets for further studies on the design of novel therapeutic strategies. He...
Source: International Journal of Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Yuchen Liu Yipin Yang Xinyi Wang Siyue Yin Bingyu Liang Yuchen Zhang Min Fan Ziyue Fu Chuanlu Shen Yanxun Han Bangjie Chen Qian Zhang Source Type: research
