FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
Int J Oncol. 2024 Feb;64(2):18. doi: 10.3892/ijo.2023.5606. Epub 2023 Dec 22.ABSTRACTFatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial growth factor (VEGF) signaling pathway were monitored. The results obtained showed that FABP5‑ or AR‑knockout (KO) led to a marked...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Abdulghani A Naeem Saud A Abdulsamad Hao Zeng Gang He Xi Jin Jiacheng Zhang Bandar T Alenezi Hongwen Ma Philip S Rudland Youqiang Ke Source Type: research
Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)
Int J Oncol. 2024 Feb;64(2):17. doi: 10.3892/ijo.2023.5605. Epub 2023 Dec 22.ABSTRACTRNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventi...
Source: International Journal of Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chiyun Shao Yanjie Han Yuying Huang Zhe Zhang Tao Gong Yajie Zhang Xiaokang Tian Mingzhi Fang Xuan Han Min Li Source Type: research
Long non ‑coding RNAs in gallbladder cancer: From mechanisms to therapeutic opportunities (Review)
Int J Oncol. 2024 Feb;64(2):16. doi: 10.3892/ijo.2023.5604. Epub 2023 Dec 15.ABSTRACTDue to the lack of specific symptoms, characteristic diagnostic markers and effective comprehensive treatment, gallbladder cancer (GBC) is currently considered one of the most malignant abdominal tumors. With the rapid development of biological technologies, long non‑coding RNAs (lncRNAs), once regarded as transcriptional junk, have been demonstrated to participate in almost the whole process of the central dogma of molecular biology. The central dogma deals with the transfer of sequential information at the level of individual residues....
Source: International Journal of Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Yingjie He Xuezhi Du Fan Yuan Caigu Yan Ming Chen Lei Han Jinjin Sun Source Type: research
[Retracted] Interaction of S100A1 with LATS1 promotes cell growth through regulation of the Hippo pathway in hepatocellular carcinoma
Int J Oncol. 2024 Feb;64(2):15. doi: 10.3892/ijo.2023.5603. Epub 2023 Dec 15.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Figs. 2B and 3E were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to International Journal of Oncology, or were under consideration for publication at around the same time. In view of the fact that certain of these data had al...
Source: International Journal of Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Qingping Guo Jiale Wang Zeyu Cao Yongchang Tang Chao Feng Feizhou Huang Source Type: research
Long non ‑coding RNAs in gallbladder cancer: From mechanisms to therapeutic opportunities (Review)
Int J Oncol. 2024 Feb;64(2):16. doi: 10.3892/ijo.2023.5604. Epub 2023 Dec 15.ABSTRACTDue to the lack of specific symptoms, characteristic diagnostic markers and effective comprehensive treatment, gallbladder cancer (GBC) is currently considered one of the most malignant abdominal tumors. With the rapid development of biological technologies, long non‑coding RNAs (lncRNAs), once regarded as transcriptional junk, have been demonstrated to participate in almost the whole process of the central dogma of molecular biology. The central dogma deals with the transfer of sequential information at the level of individual residues....
Source: International Journal of Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Yingjie He Xuezhi Du Fan Yuan Caigu Yan Ming Chen Lei Han Jinjin Sun Source Type: research
