Revolutionizing breast cancer treatment: Harnessing the related mechanisms and drugs for regulated cell death (Review)
Int J Oncol. 2024 May;64(5):46. doi: 10.3892/ijo.2024.5634. Epub 2024 Mar 8.ABSTRACTBreast cancer arises from the malignant transformation of mammary epithelial cells under the influence of various carcinogenic factors, leading to a gradual increase in its prevalence. This disease has become the leading cause of mortality among female malignancies, posing a significant threat to the health of women. The timely identification of breast cancer remains challenging, often resulting in diagnosis at the advanced stages of the disease. Conventional therapeutic approaches, such as surgical excision, chemotherapy and radiotherapy, ...
Source: International Journal of Oncology - March 8, 2024 Category: Cancer & Oncology Authors: Leyu Ai Na Yi Chunhan Qiu Wanyi Huang Keke Zhang Qiulian Hou Long Jia Hui Li Ling Liu Source Type: research

Revolutionizing breast cancer treatment: Harnessing the related mechanisms and drugs for regulated cell death (Review)
Int J Oncol. 2024 May;64(5):46. doi: 10.3892/ijo.2024.5634. Epub 2024 Mar 8.ABSTRACTBreast cancer arises from the malignant transformation of mammary epithelial cells under the influence of various carcinogenic factors, leading to a gradual increase in its prevalence. This disease has become the leading cause of mortality among female malignancies, posing a significant threat to the health of women. The timely identification of breast cancer remains challenging, often resulting in diagnosis at the advanced stages of the disease. Conventional therapeutic approaches, such as surgical excision, chemotherapy and radiotherapy, ...
Source: International Journal of Oncology - March 8, 2024 Category: Cancer & Oncology Authors: Leyu Ai Na Yi Chunhan Qiu Wanyi Huang Keke Zhang Qiulian Hou Long Jia Hui Li Ling Liu Source Type: research

Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
Int J Oncol. 2024 Apr;64(4):44. doi: 10.3892/ijo.2024.5632. Epub 2024 Mar 1.ABSTRACTCancer is one of the leading causes of mortality worldwide. The etiology of cancer has not been fully elucidated yet, and further enhancements are necessary to optimize therapeutic efficacy. Butyrate, a short‑chain fatty acid, is generated through gut microbial fermentation of dietary fiber. Studies have unveiled the relevance of butyrate in malignant neoplasms, and a comprehensive understanding of its role in cancer is imperative for realizing its full potential in oncological treatment. Its full antineoplastic effects via the activation...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Jinzhe Sun Shiqian Chen Dan Zang Hetian Sun Yan Sun Jun Chen Source Type: research

Lysine methyltransferase  5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis
Int J Oncol. 2024 Apr;64(4):45. doi: 10.3892/ijo.2024.5633. Epub 2024 Mar 1.ABSTRACTAmong all types of renal cancer, clear cell renal cell carcinoma (ccRCC) is the most common and lethal subtype and is associated with a high risk of metastasis and recurrence. Histone modifications regulate several biological processes that are fundamental to the development of cancer. Lysine methyltransferase 5C (KMT5C; also known as SUV420H2) is an epigenetic modifier responsible for the trimethylation of H4K20, which drives critical cellular events, including genome integrity, cell growth and epithelial‑mesenchymal transition (EMT), in...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Bohan Zeng Runlan Wan Kun Chang Jing Li Xuanzhi Zhang Guohai Shi Dingwei Ye Fujiang Xu Source Type: research

Targeting mitochondrial bioenergetics by combination treatment with imatinib and dichloroacetate in human erythroleukemic K ‑562 and colorectal HCT‑116 cancer cells
Int J Oncol. 2024 Apr;64(4):42. doi: 10.3892/ijo.2024.5630. Epub 2024 Mar 1.ABSTRACTTumor malignant cells are characterized by dysregulation of mitochondrial bioenergetics due to the 'Warburg effect'. In the present study, this metabolic imbalance was explored as a potential target for novel cancer chemotherapy. Imatinib (IM) downregulates the expression levels of SCΟ2 and FRATAXIN (FXN) genes involved in the heme‑dependent cytochrome c oxidase biosynthesis and assembly pathway in human erythroleukemic IM‑sensitive K‑562 chronic myeloid leukemia cells (K‑562). In the present study, it was investigated whether the ...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Maria G Kakafika Areti A Lyta George I Gavriilidis Stefanos A Tsiftsoglou Androulla N Miliotou Ioannis S Pappas Ioannis S Vizirianakis Lefkothea C Papadopoulou Asterios S Tsiftsoglou Source Type: research

Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer
Int J Oncol. 2024 Apr;64(4):43. doi: 10.3892/ijo.2024.5631. Epub 2024 Mar 1.ABSTRACTDespite advances in treatment and early detection, breast cancer remains one of the most common types of cancer and is the second leading cause of cancer death after lung cancer in women. Therefore, there is an urgent need to develop new biomarkers and therapeutic targets for the treatment of breast cancer. Based on gene expression profiles and subsequent screening performed in a preliminary study, kinesin family member 20B (KIF20B) was selected as a candidate target molecule, because it was highly and frequently expressed in all subtypes o...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Regina Wachuka Mbugua Atsushi Takano Bayarbat Tsevegjav Tomoyuki Yokose Toshinari Yamashita Yohei Miyagi Yataro Daigo Source Type: research

Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
Int J Oncol. 2024 Apr;64(4):44. doi: 10.3892/ijo.2024.5632. Epub 2024 Mar 1.ABSTRACTCancer is one of the leading causes of mortality worldwide. The etiology of cancer has not been fully elucidated yet, and further enhancements are necessary to optimize therapeutic efficacy. Butyrate, a short‑chain fatty acid, is generated through gut microbial fermentation of dietary fiber. Studies have unveiled the relevance of butyrate in malignant neoplasms, and a comprehensive understanding of its role in cancer is imperative for realizing its full potential in oncological treatment. Its full antineoplastic effects via the activation...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Jinzhe Sun Shiqian Chen Dan Zang Hetian Sun Yan Sun Jun Chen Source Type: research

Lysine methyltransferase  5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis
Int J Oncol. 2024 Apr;64(4):45. doi: 10.3892/ijo.2024.5633. Epub 2024 Mar 1.ABSTRACTAmong all types of renal cancer, clear cell renal cell carcinoma (ccRCC) is the most common and lethal subtype and is associated with a high risk of metastasis and recurrence. Histone modifications regulate several biological processes that are fundamental to the development of cancer. Lysine methyltransferase 5C (KMT5C; also known as SUV420H2) is an epigenetic modifier responsible for the trimethylation of H4K20, which drives critical cellular events, including genome integrity, cell growth and epithelial‑mesenchymal transition (EMT), in...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Bohan Zeng Runlan Wan Kun Chang Jing Li Xuanzhi Zhang Guohai Shi Dingwei Ye Fujiang Xu Source Type: research

Targeting mitochondrial bioenergetics by combination treatment with imatinib and dichloroacetate in human erythroleukemic K ‑562 and colorectal HCT‑116 cancer cells
Int J Oncol. 2024 Apr;64(4):42. doi: 10.3892/ijo.2024.5630. Epub 2024 Mar 1.ABSTRACTTumor malignant cells are characterized by dysregulation of mitochondrial bioenergetics due to the 'Warburg effect'. In the present study, this metabolic imbalance was explored as a potential target for novel cancer chemotherapy. Imatinib (IM) downregulates the expression levels of SCΟ2 and FRATAXIN (FXN) genes involved in the heme‑dependent cytochrome c oxidase biosynthesis and assembly pathway in human erythroleukemic IM‑sensitive K‑562 chronic myeloid leukemia cells (K‑562). In the present study, it was investigated whether the ...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Maria G Kakafika Areti A Lyta George I Gavriilidis Stefanos A Tsiftsoglou Androulla N Miliotou Ioannis S Pappas Ioannis S Vizirianakis Lefkothea C Papadopoulou Asterios S Tsiftsoglou Source Type: research

Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer
Int J Oncol. 2024 Apr;64(4):43. doi: 10.3892/ijo.2024.5631. Epub 2024 Mar 1.ABSTRACTDespite advances in treatment and early detection, breast cancer remains one of the most common types of cancer and is the second leading cause of cancer death after lung cancer in women. Therefore, there is an urgent need to develop new biomarkers and therapeutic targets for the treatment of breast cancer. Based on gene expression profiles and subsequent screening performed in a preliminary study, kinesin family member 20B (KIF20B) was selected as a candidate target molecule, because it was highly and frequently expressed in all subtypes o...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Regina Wachuka Mbugua Atsushi Takano Bayarbat Tsevegjav Tomoyuki Yokose Toshinari Yamashita Yohei Miyagi Yataro Daigo Source Type: research

Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
Int J Oncol. 2024 Apr;64(4):44. doi: 10.3892/ijo.2024.5632. Epub 2024 Mar 1.ABSTRACTCancer is one of the leading causes of mortality worldwide. The etiology of cancer has not been fully elucidated yet, and further enhancements are necessary to optimize therapeutic efficacy. Butyrate, a short‑chain fatty acid, is generated through gut microbial fermentation of dietary fiber. Studies have unveiled the relevance of butyrate in malignant neoplasms, and a comprehensive understanding of its role in cancer is imperative for realizing its full potential in oncological treatment. Its full antineoplastic effects via the activation...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Jinzhe Sun Shiqian Chen Dan Zang Hetian Sun Yan Sun Jun Chen Source Type: research

Lysine methyltransferase  5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis
Int J Oncol. 2024 Apr;64(4):45. doi: 10.3892/ijo.2024.5633. Epub 2024 Mar 1.ABSTRACTAmong all types of renal cancer, clear cell renal cell carcinoma (ccRCC) is the most common and lethal subtype and is associated with a high risk of metastasis and recurrence. Histone modifications regulate several biological processes that are fundamental to the development of cancer. Lysine methyltransferase 5C (KMT5C; also known as SUV420H2) is an epigenetic modifier responsible for the trimethylation of H4K20, which drives critical cellular events, including genome integrity, cell growth and epithelial‑mesenchymal transition (EMT), in...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Bohan Zeng Runlan Wan Kun Chang Jing Li Xuanzhi Zhang Guohai Shi Dingwei Ye Fujiang Xu Source Type: research

Targeting mitochondrial bioenergetics by combination treatment with imatinib and dichloroacetate in human erythroleukemic K ‑562 and colorectal HCT‑116 cancer cells
Int J Oncol. 2024 Apr;64(4):42. doi: 10.3892/ijo.2024.5630. Epub 2024 Mar 1.ABSTRACTTumor malignant cells are characterized by dysregulation of mitochondrial bioenergetics due to the 'Warburg effect'. In the present study, this metabolic imbalance was explored as a potential target for novel cancer chemotherapy. Imatinib (IM) downregulates the expression levels of SCΟ2 and FRATAXIN (FXN) genes involved in the heme‑dependent cytochrome c oxidase biosynthesis and assembly pathway in human erythroleukemic IM‑sensitive K‑562 chronic myeloid leukemia cells (K‑562). In the present study, it was investigated whether the ...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Maria G Kakafika Areti A Lyta George I Gavriilidis Stefanos A Tsiftsoglou Androulla N Miliotou Ioannis S Pappas Ioannis S Vizirianakis Lefkothea C Papadopoulou Asterios S Tsiftsoglou Source Type: research

Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer
Int J Oncol. 2024 Apr;64(4):43. doi: 10.3892/ijo.2024.5631. Epub 2024 Mar 1.ABSTRACTDespite advances in treatment and early detection, breast cancer remains one of the most common types of cancer and is the second leading cause of cancer death after lung cancer in women. Therefore, there is an urgent need to develop new biomarkers and therapeutic targets for the treatment of breast cancer. Based on gene expression profiles and subsequent screening performed in a preliminary study, kinesin family member 20B (KIF20B) was selected as a candidate target molecule, because it was highly and frequently expressed in all subtypes o...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Regina Wachuka Mbugua Atsushi Takano Bayarbat Tsevegjav Tomoyuki Yokose Toshinari Yamashita Yohei Miyagi Yataro Daigo Source Type: research

Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
Int J Oncol. 2024 Apr;64(4):44. doi: 10.3892/ijo.2024.5632. Epub 2024 Mar 1.ABSTRACTCancer is one of the leading causes of mortality worldwide. The etiology of cancer has not been fully elucidated yet, and further enhancements are necessary to optimize therapeutic efficacy. Butyrate, a short‑chain fatty acid, is generated through gut microbial fermentation of dietary fiber. Studies have unveiled the relevance of butyrate in malignant neoplasms, and a comprehensive understanding of its role in cancer is imperative for realizing its full potential in oncological treatment. Its full antineoplastic effects via the activation...
Source: International Journal of Oncology - March 1, 2024 Category: Cancer & Oncology Authors: Jinzhe Sun Shiqian Chen Dan Zang Hetian Sun Yan Sun Jun Chen Source Type: research