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Anti-Mi-2 antibody-positive lung cancer-associated polymyositis
AbstractAfter a 75-year-old man was diagnosed with lung cancer, proximal weakness and myalgia in the bilateral lower extremities developed, and the creatinine kinase (CK) level was elevated. The anti-Mi-2 antibody test was positive, muscle T2-weighted/fat-suppressed magnetic resonance imaging showed high intensity, and there were no skin lesions. Therefore, he was diagnosed with lung cancer-associated polymyositis (PM). The lung tumour shrank after chemotherapy, accompanied by gradual improvement of his PM-derived symptoms and CK level. Although positive anti-Mi-2 antibody tests rarely indicate PM and cancer, examining myo...
Source: International Cancer Conference Journal - March 14, 2023 Category: Cancer & Oncology Source Type: research

A case of solitary lymph node recurrence 9  years after initial treatment for advanced premenopausal endometrioid endometrial cancer; clinical usefulness of hormonal replacement therapy
We report a case of advanced corpus cancer at a young age, in which HRT was initiated 7  years after surgery, and regional lymph node recurrence was later detected. The patient was 35 years old at the time of initial treatment in X year, when she was diagnosed with stageIIIC2 corpus cancer and underwent a hysterectomy with bilateral salpingo-oophorectomy and a retroperitoneal lymphad enectomy. HRT was started at X + 7 years, and at X + 9 years, a 25 × 12-mm-sized mass was found in the hilum of the right kidney. A laparoscopic resection revealed regional lymph node recurrence of the corpus cancer. A retrosp...
Source: International Cancer Conference Journal - March 10, 2023 Category: Cancer & Oncology Source Type: research

Local recurrence of breast cancer histologically resembling Paget disease presumably due to needle tract seeding: a case report
AbstractSeeding of cancer cells along the needle tract during core needle biopsy is a well-known phenomenon, with a reported frequency of between 22 and 50% [Hoorntje et al. in Eur J Surg Oncol 30:520 –525, 2004;Liebens et al. in Maturitas 62:113–123, 2009;Diaz et al. in AJR Am J Roentgenol 173:1303–1313, 1999;]. Local recurrence due to needle tract seeding is rare because the immune system eliminates the cancer cells in most cases. In addition, most local recurrences due to needle tract se eding occur as invasive carcinoma after diagnosis of invasive ductal carcinoma of the breast or mucinous carcinoma, and needle t...
Source: International Cancer Conference Journal - February 20, 2023 Category: Cancer & Oncology Source Type: research

COVID arm that appeared in the contralateral upper extremity after mRNA-1273 booster inoculation
We report the findings of a 60-year-old female patient with metastatic breast cancer who presented with severe edema and neuralgia in the contralateral arm after receiving the third COVID-19 vaccine dose. The patient did not report any reaction to the first two doses of the BNT162b2 (Pfizer-BioNTech) vaccine. However, after a booster dose with the mRNA-1273 (Moderna) vaccine, the patient developed a high fever persisting for one week after the shot, and sequential severe swelling, inflammation, and pain in the contralateral arm lasting for three weeks. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - February 20, 2023 Category: Cancer & Oncology Source Type: research

Proton beam therapy for cervical lymph node metastasis in an octogenarian with melanoma of unknown primary: a case report
AbstractAn 80-year-old man with an approximately 3-cm mass in the right submandibular region presented to our institution. Magnetic resonance imaging revealed enlarged lymph nodes (LNs) in the right neck, and fluorine-18-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) indicated positive FDG accumulation in the right neck LNs only. Excisional biopsy was performed for suspected malignant lymphoma, and the biopsy revealed melanoma. Close examination of the skin, nasal cavity, oral pharyngeal and laryngeal cavities, and gastrointestinal tract were performed. No primary tumor was detected by ...
Source: International Cancer Conference Journal - February 1, 2023 Category: Cancer & Oncology Source Type: research

Rhabdomyosarcoma mimicking lymphoma
ConclusionMetastatic RMS can mimic lymphoproliferative disorders at presentation. Clinicians must be aware of this diagnosis especially in young adults. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - February 1, 2023 Category: Cancer & Oncology Source Type: research

Total pancreatectomy preserving the right gastroepiploic artery following proximal gastrectomy
AbstractTotal pancreatectomy (TP) after proximal gastrectomy (PG) requires more attention than ordinary TP during surgery in terms of the preservation of blood flow to the remnant stomach that was supplied via only the right gastric and gastroepiploic arteries. The current report presents the details of a case in which the remnant stomach was safely preserved when performing TP. A 74-year-old man who underwent PG for gastric cancer 17  years previously was diagnosed with pancreatic head cancer during follow-up for intraductal papillary mucinous neoplasm of the pancreatic body and tail. To preserve digestive function and r...
Source: International Cancer Conference Journal - January 23, 2023 Category: Cancer & Oncology Source Type: research

ATM mutation in aggressive uterine adenosarcoma in which systemic chemotherapies had remarkable effects
This study presents a case of uterine adenosarcoma without sarcomatous overgrowth but withTP53 mutation that exhibited clinically aggressive behaviors. The patient had anATM mutation, which is a gene associated with homologous recombination deficiency, and exhibited a good response against platinum-based chemotherapy and possible therapeutic target by poly(ADP-ribose) polymerase inhibitors. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - January 12, 2023 Category: Cancer & Oncology Source Type: research

A case of advanced breast cancer with Gitelman syndrome
AbstractGitelman syndrome (GS) is a rare, mostly autosomal recessive disease this is a salt-losing tubulopathy caused by mutation of genes encoding sodium chloride (NCCT) and magnesium transporters in the thiazide-sensitive segments of the distal nephron. We encountered a 45-year-old female who has suffered from whole-body weakness because of hypokalemia for 8  years and diagnosed with Gitelman syndrome clinically. She visited the hospital with a complaint of an unrelieved hard mass of the left breast. The tumor was diagnosed as human epidermal growth factor receptor 2 (HER2)-positive breast cancer. We herein report this ...
Source: International Cancer Conference Journal - January 4, 2023 Category: Cancer & Oncology Source Type: research

Interstitial pneumonia after regression by olaparib for neuroendocrine prostate cancer with BRCA1 mutation: a case report
AbstractA 67-year-old man with metastatic prostate cancer was treated with leuprorelin and enzalutamide, but presented radiographic progression after 1  year. Although docetaxel chemotherapy was initiated, liver metastasis appeared with elevation of nerve-specific enolase in serum. Pathological findings of needle biopsy of lymph node metastasis in the right inguinal region showed neuroendocrine carcinoma. FoundationOne CDx® using a biopsy sample of the prostate at initial diagnosis detected theBRCA1 mutation (deletion of intron 3 –7), but BRACAnalysis® test revealed noBRCA mutation in germline. Then, olaparib treatmen...
Source: International Cancer Conference Journal - January 3, 2023 Category: Cancer & Oncology Source Type: research

A case of paraovarian tumor of borderline malignancy with decrease of apparent diffusion coefficient value and marked 18F-fluorodeoxyglucose accumulation
AbstractPara-ovarian cysts are occasionally encountered in clinical practice; however, malignant tumors derived from them are rare. Due to its rarity, the characteristic imaging findings of para-ovarian tumors with borderline malignancy (PTBM) are largely unknown. Herein, we report a case of PTBM, along with imaging findings. A 37-year-old woman came to our department with a suspected malignant adnexal tumor. Pelvic contrast-enhanced magnetic resonance imaging (MRI) revealed a solid part within the cystic tumor with a decrease in the apparent diffusion coefficient (ADC) value (1.16  × 10–3 mm2/s). We also performed...
Source: International Cancer Conference Journal - December 31, 2022 Category: Cancer & Oncology Source Type: research

Surgical resection of primary leiomyosarcoma of retro-hepatic inferior vena cava extending from bilateral renal veins across the diaphragm
This report describes the case of advanced leiomyosarcoma of the inferior vena cava that was successfully treated with surgery and subsequent chemotherapy. A 44-year-old man was fo und to have a 12 × 10 cm retroperitoneal tumor on computed tomography. The tumor originated in the inferior vena cava and extended beyond the diaphragm into the renal vein. The surgical plan was determined in joint consultation with the multidisciplinary team. It was safely resected and the in ferior vena cava was closed caudal to the porta hepatis without a synthetic graft. The tumor was diagnosed as leiomyosarcoma. Doxorubicin, followed ...
Source: International Cancer Conference Journal - December 29, 2022 Category: Cancer & Oncology Source Type: research

Primary esophageal malignant melanoma without recurrence after surgery and adjuvant therapy with nivolumab
AbstractPrimary malignant melanoma of the esophagus is a rare disease with a severely poor prognosis. Here, we report a patient with primary malignant melanoma of the esophagus surviving without recurrence after surgery and adjuvant therapy with nivolumab. The patient was a 60-year-old female with dysphagia. Esophagogastroscopy showed an elevated dark brown tumor in the lower thoracic esophagus. A histological examination of the biopsy revealed human melanoma black 45 and melan-A positivity. The patient was diagnosed with primary malignant melanoma of the esophagus and was treated with radical esophagectomy. As postoperati...
Source: International Cancer Conference Journal - December 21, 2022 Category: Cancer & Oncology Source Type: research

Liver metastases of a neuroendocrine tumor arising from a tailgut cyst treated with interventional locoregional therapies: a case report and review of the literature on recurrent cases
AbstractA tailgut cyst is a rare, developmental cyst occurring in the presacral space. Although primarily benign, malignant transformation is a possible complication. Herein, we report a case of liver metastases after resection of a neuroendocrine tumor (NET) arising from a tailgut cyst. A 53-year-old woman underwent surgery for a presacral cystic lesion with nodules in the cyst wall. The tumor was diagnosed as a Grade 2 NET arising from a tailgut cyst. Thirty-eight months after surgery, multiple liver metastases were identified. The liver metastases were controlled with transcatheter arterial embolization and ablation the...
Source: International Cancer Conference Journal - December 19, 2022 Category: Cancer & Oncology Source Type: research

Myocarditis associated with immune-checkpoint inhibitors diagnosed by cardiac magnetic resonance imaging
We report a case of myocarditis after ICIs administration, which was diagnosed using CMRI in a 48-year-old male with lung adenocarcinoma. CMRI provides an opportunity to diagnose myocarditis during cancer treatment. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - December 13, 2022 Category: Cancer & Oncology Source Type: research